Drug Kinetics And Drug Resistance In Optimal Chemotherapy

dc.creatorCosta M.I.S.
dc.creatorBoldrini J.L.
dc.creatorBassanezi R.C.
dc.date1995
dc.date2015-06-26T17:15:06Z
dc.date2015-11-26T14:21:14Z
dc.date2015-06-26T17:15:06Z
dc.date2015-11-26T14:21:14Z
dc.date.accessioned2018-03-28T21:22:59Z
dc.date.available2018-03-28T21:22:59Z
dc.identifier
dc.identifierMathematical Biosciences. , v. 125, n. 2, p. 191 - 209, 1995.
dc.identifier255564
dc.identifier10.1016/0025-5564(94)00027-W
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0029240378&partnerID=40&md5=ade2b04aff829360d1a2e1826e6e8b3f
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/96095
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/96095
dc.identifier2-s2.0-0029240378
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244473
dc.descriptionA system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. First-order drug kinetics and drug resistance are taken into account in a class of optimal control problems. The results show that the strategy corresponding to the maximum rate of drug injection is optimal for the Malthusian model of cell growth (which is a relatively good model for the initial phase of tumor growth). For more general models of cell growth, this strategy proved to be suboptimal under certain conditions. © 1995.
dc.description125
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dc.description191
dc.description209
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dc.languageen
dc.publisher
dc.relationMathematical Biosciences
dc.rightsfechado
dc.sourceScopus
dc.titleDrug Kinetics And Drug Resistance In Optimal Chemotherapy
dc.typeArtículos de revistas


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