Dissimilarity Between Prostaglandin E1 And Nitric Oxide Donors As Potentiators Of Plasma Exudation In The Rabbit Skin In Vivo

dc.creatorMariani-Pedroso S.R.
dc.creatorBizeto L.
dc.creatorAntunes E.
dc.creatorZatz R.
dc.creatorde Nucci G.
dc.date1995
dc.date2015-06-26T17:14:36Z
dc.date2015-11-26T14:20:36Z
dc.date2015-06-26T17:14:36Z
dc.date2015-11-26T14:20:36Z
dc.date.accessioned2018-03-28T21:22:17Z
dc.date.available2018-03-28T21:22:17Z
dc.identifier
dc.identifierProstaglandins, Leukotrienes And Essential Fatty Acids. , v. 52, n. 6, p. 399 - 402, 1995.
dc.identifier9523278
dc.identifier10.1016/0952-3278(95)90068-3
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0028989032&partnerID=40&md5=e3f21fd7e61ff65641b41ba7eff0d005
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/95948
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/95948
dc.identifier2-s2.0-0028989032
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244295
dc.descriptionThe ability of prostaglandin E1 (PGE1) and nitric oxide (NO) donor compounds such as sodium nitroprusside (SNP), glyceryl trinitrate (GTN), and 3-morpholino-sydnonimine (SIN-1) to modulate the histamine- and bradykinin-induced increase in microvascular permeability have been investigated in rabbit skin. The effect of the NO synthesis inhibitor Nω-nitro-l-arginine methyl ester (l-NAME) on the plasma exudation induced by histamine and bradykinin was also studied. Local edema formation was evaluated using [125I]human serum albumin. New Zealand white rabbits received an intravenous injection of [125I]human albumin followed immediately by the intradermal injection of edematogenic agents into the shaved dorsolateral skin. PGE1 (0.1 nmol/site) significantly potentiated both histamine- and bradykinin-induced edema. In contrast, SNP (0.4-400 nmol/site), SIN-1 (0.4-400 nmol/site), and GTN (0.4-40 nmol/site) did not affect the edematogenic response induced by either histamine or bradykinin. GTN (0.4-40 nmol/site) also had no effect on the increase in plasma exudation induced by histamine and bradykinin in the presence of PGE1. l-NAME (50-400 nmol/site), but not its enantiomer d-NAME, dose-dependently reduced the edema formation induced by a combination of either histamine or bradykinin with PGE1. This inhibition was significantly reversed by SNP (4-400 nmol/site) and by high doses (2.5 μmol/site) of l-arginine (but not by d-arginine). Our results thus demonstrate that PGE1, but not nitrovasodilators, can actually potentiate histamine- and bradykinin-induced edema in rabbit skin. This discrepancy cannot be explained by the lack of vasodilator activity of the nitrovasodilators since these were able to reverse the l-NAME-induced inhibition of the edema provoked by histamine. Rather, this difference most likely reflects the ability of PGE1 to modulate vascular permeability by mechanism(s) other than an increase in arterial flow. © 1995.
dc.description52
dc.description6
dc.description399
dc.description402
dc.descriptionSpector, Willoughby, Endogenous mediators of increased vascular permeability in inflammation (1968) The pharmacology of inflammation, pp. 22-54. , Butler, Tanner, The English Universities Press, Frome and London
dc.descriptionMorley, Page, Paul, Inflammatory actions of platelet-activating factor (PAF-acether) in guinea-pig skin (1983) Br J Pharmacol, 80, pp. 503-509
dc.descriptionMcGivern, Basran, Synergism between platelet-activating factor (PAF-acether) and prostaglandin E2 in man (1984) Eur J Pharmacol, 102, pp. 183-185
dc.descriptionHwang, Li, Lam, Shen, Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea-pigs and rats and its inhibition by a platelet-activating factor receptor antagonist (1985) Lab Invest, 52, pp. 617-630
dc.descriptionChahl, Interactions of substance P with putative mediators of inflammation and ATP (1977) Eur J Pharmacol, 44, pp. 45-49
dc.descriptionLembeck, Holzer, Substance P as a mediator of antidromic vasodilatation and neurogenic plasma extravasation (1979) Naunyn-Schmiedeb Arch Pharmacol, 310, pp. 175-183
dc.descriptionGamse, Saria, Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide (1985) Eur J Pharmacol, 114, pp. 61-66
dc.descriptionBrain, Williams, Substance P regulates the vasodilator activity of calcitonin gene-related peptide (1988) Nature, 335, pp. 73-75
dc.descriptionPeck, Piper, Williams, The effect of leukotrienes C4 and D4 on the microvasculature of guinea-pig skin (1981) Prostaglandins, 21, pp. 315-321
dc.descriptionUeno, Tanaka, Katori, Hayashi, Arai, Species differences in increased vascular permeability by synthetic leukotrienes C4 and D4 (1981) Prostaglandins, 21, pp. 637-648
dc.descriptionBray, Cunningham, Ford-Hutchinson, Smith, Leukotriene B4: a mediator of vascular permeability (1981) Br J Pharmacol, 72, pp. 483-486
dc.descriptionWilliams, Morley, Prostaglandins as potentiators of increased permeability in inflammation (1973) Nature, 246, pp. 215-217
dc.descriptionWilliams, Peck, Role of prostaglandin-mediated vasodilatation in inflammation (1977) Nature, 270, pp. 530-532
dc.descriptionWilliams, Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation (1979) Br J Pharmacol, 65, pp. 517-524
dc.descriptionBrain, Williams, Inflammatory edema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability (1985) Br J Pharmacol, 86, pp. 855-860
dc.descriptionWilliams, Vasoactive intestinal polypeptide is more potent than prostaglandin E2 as a vasodilator and edema potentiator in rabbit skin (1982) Br J Pharmacol, 77, pp. 505-509
dc.descriptionFurchgott, Zawadzki, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine (1980) Nature, 286, pp. 373-376
dc.descriptionPalmer, Ferrige, Moncada, Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor (1987) Nature, 327, pp. 524-526
dc.descriptionIgnarro, Buga, Wood, Byrns, Chaudhuri, Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide (1987) Proc Natl Acad Sci USA, 84, pp. 9265-9269
dc.descriptionMyers, Minor, Jr, Guerra, Jr, Bates, Harrison, Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide (1990) Nature, 345, pp. 161-163
dc.descriptionHughes, Williams, Brain, Evidence that endogenous nitric oxide modulates edema formation induced by substance P (1990) Eur J Pharmacol, 191, pp. 481-484
dc.descriptionLalenti, Lanaro, Moncada, Di Rosa, Modulation of acute inflammation by endogenous nitric oxide (1992) European Journal of Pharmacology, 211, pp. 177-182
dc.descriptionAntunes, Giraldelo, Cirino, de Nucci, Effects of Nω-monomethyl-l-arginine and its d-enantiomer on rat hind-paw edema (1992) Biology of nitric oxide — Physiological and clinical aspects, pp. 264-266. , S Moncada, MA Marletta, JB Hibbs, EA Higgs, Portland Press
dc.descriptionKubes, Granger, Nitric oxide modulates microvascular permeability (1992) Am J Physiol, 262, pp. H611-H615
dc.descriptionKurose, Kubes, Wolf, Inhibition of nitric oxide production (1993) Mechanisms of vascular protein leakage, 73, pp. 164-171. , Circ Res
dc.descriptionGiraldelo C M M, Zappellini A, Muscará M N et al. Effects of arginine analogues on rat hind paw oedema and mast cell activation in vitro. Eur J Pharmacol in pressMurad, Mittal, Arnold, Katsuki, Kimura, Guanylate cyclase: activation by azide, nitro compounds, nitric oxide and hydroxyl radical and inhibition by hemoglobin and myoglobin (1978) Advances in cyclic nucleotide research, pp. 145-158. , WJ George, LJ Ignarro, Raven Press, New York
dc.descriptionFeelisch, Noack, Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase (1987) Eur J Pharmacol, 139, pp. 19-30
dc.descriptionWaldman, Murad, Cyclic G M P synthesis and function (1987) Pharmacol Rev, 39, pp. 163-196
dc.descriptionSchafer, Alexander, Handin, Inhibition of platelet function by organic nitrate vasodilators (1980) Blood, 55, pp. 649-654
dc.descriptionLidbury, Antunes, de Nucci, Vane, Interactions of iloprost and sodium nitroprusside in platelets and vascular smooth muscle (1989) Br J Pharmacol, 98, pp. 1275-1280
dc.descriptionWilson, Warren, Adenylate cyclase-mediated vascular responses of rabbit aorta, mesenteric artery and skin microcirculation (1993) Br J Pharmacol, 110, pp. 633-638
dc.descriptionFilep, Foldes-Filep, Sirois, Nitric oxide modulates vascular permeability in the rat coronary circulation (1993) Br J Pharmacol, 108, pp. 323-326
dc.descriptionYoung, Mayhan, Effect of prostaglandin E1 on leukotriene C4-induced increases in vascular permeability of hamster cheek pouch (1992) Inflammation, 16, pp. 159-167
dc.descriptionGrega, Maciejko, Raymond, Sak, The interrelationship among histamine, various vasoactive substances, and macromolecular permeability in the canine forelimb (1980) Circ Res, 46, pp. 264-275
dc.descriptionAmelang, Prasad, Raymond, Grega, Interactions among inflammatory mediators on edema formation in the canine forelimb (1981) Circ Res, 49, pp. 298-306
dc.languageen
dc.publisher
dc.relationProstaglandins, Leukotrienes and Essential Fatty Acids
dc.rightsfechado
dc.sourceScopus
dc.titleDissimilarity Between Prostaglandin E1 And Nitric Oxide Donors As Potentiators Of Plasma Exudation In The Rabbit Skin In Vivo
dc.typeArtículos de revistas


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