The Ability Of Specific Antivenom And Low Temperature To Inhibit The Myotoxicity And Neuromuscular Block Induced By Micrurus Nigrocinctus Venom

dc.creatorGoularte F.C.
dc.creatorCruz-Hofling M.A.
dc.creatorCogo J.C.
dc.creatorGutierrez J.M.
dc.creatorRodrigues-Simioni L.
dc.date1995
dc.date2015-06-26T17:13:41Z
dc.date2015-11-26T14:19:44Z
dc.date2015-06-26T17:13:41Z
dc.date2015-11-26T14:19:44Z
dc.date.accessioned2018-03-28T21:21:15Z
dc.date.available2018-03-28T21:21:15Z
dc.identifier
dc.identifierToxicon. , v. 33, n. 5, p. 679 - 689, 1995.
dc.identifier410101
dc.identifier10.1016/0041-0101(94)00178-B
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0029018365&partnerID=40&md5=eb73123673f2a8073cc1b0a7c73e391f
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/95775
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/95775
dc.identifier2-s2.0-0029018365
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1244032
dc.descriptionIn the isolated mouse diaphragm preparation, Micrurus nigrocinctus venom produced a dose-dependent contracture and blockade of the contractile response to direct and indirect electrical stimulation of the muscle. This effect could not be completely reversed by repeated washing of the preparation nor by the addition of neostigmine or 3,4-diaminopyridine. The observation that the direct blockade had to be preceded by indirect blockade together with the capacity of the venom to prevent the ACh- but not the KCl-induced contractures in biventer cervicis and chronically denervated preparations strongly suggests a curarimimetic action for the venom. The temperature at which the experiment was performed greatly influenced the neuromuscular blocking and myotoxic actions of the venom and suggests that the venom component responsible for these effects is thermolabile. Both the neuromuscular blocking action and the myotoxicity of the venom could be prevented by a specific M. nigrocinctus antivenom regardless of whether this was added together with or after the venom. The muscle morphological changes induced by the venom were accompanied by a corresponding increase in the release of creatine kinase (CK) into the incubation medium. This release was, however, submaximal (35%) when compared to that induced by the detergent Triton X-100. In contrast to what has been demonstrated for other Micrurus venoms (M. frontalis, M. corallinus, M. lemniscatus and M. spixii), our results show that the myotoxic effect induced by M. nigrocinctus venom is important for the development of irreversible blockade of the muscle contractile response. © 1995.
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dc.languageen
dc.publisher
dc.relationToxicon
dc.rightsfechado
dc.sourceScopus
dc.titleThe Ability Of Specific Antivenom And Low Temperature To Inhibit The Myotoxicity And Neuromuscular Block Induced By Micrurus Nigrocinctus Venom
dc.typeArtículos de revistas


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