Mode Of Action Of Duvernoy's Gland Extracts From The Colubrid Dryadophis Biofossatus In The Chick Biventer Cervicis Nerve-muscle Preparation

dc.creatorFontana M.D.
dc.creatorHeleno M.G.
dc.creatorVital Brazil O.
dc.date1996
dc.date2015-06-26T17:04:11Z
dc.date2015-11-26T14:19:34Z
dc.date2015-06-26T17:04:11Z
dc.date2015-11-26T14:19:34Z
dc.date.accessioned2018-03-28T21:21:03Z
dc.date.available2018-03-28T21:21:03Z
dc.identifier
dc.identifierToxicon. , v. 34, n. 10, p. 1187 - 1190, 1996.
dc.identifier410101
dc.identifier10.1016/0041-0101(96)00066-9
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0030273665&partnerID=40&md5=b1569e2db75cac1359dd1ad80b218bd6
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/95743
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/95743
dc.identifier2-s2.0-0030273665
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1243976
dc.descriptionExtracts and secretion of the Duvernoy's gland are venomous, inducing in several cases motor paralysis in experimental animals. The extracts of the Duvernoy's gland from the aglyphous colubrid Dryadophis bifossatus are very toxic, eliciting flaccid paralysis in pigeons, rabbits and Hylae (Brazil and Vellard, 1926). In the present study, the neuromuscular action of the extracts of Duvernoy's gland from this Colubridae was investigated in the chick biventer cervicis nerve-muscle preparation. The muscle was indirectly stimulated with supramaximal purses, and by addition of acetylcholine or carbachol to the organ bath. Direct muscle stimulation was carried out in curarized preparations. The extracts induced an irreversible neuromuscular blockade and also inhibited irreversibly the contracture of the biventer cervicis produced by either acetylcholine or carbachol. The twitches elicited by direct muscle stimulation were not depressed. These results show that the neurotoxin(s) of the extracts interact with the end-plate cholinergic receptors.
dc.description34
dc.description10
dc.description1187
dc.description1190
dc.descriptionBrazil, V., Vellard, J., Contribuição ao estudo das glândulas das serpentes aglyphas (1926) Mem. Inst. Butantan, 3, pp. 301-325
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dc.descriptionKraus, R., Ueber biologische schlangenforchung (1924) Mem. Inst. Butantan, 3, pp. 301-325. , Brazil, V. and Vellard, J. (1926) Contribuição ao estudo das glândulas das serpentes agtyphas
dc.descriptionLevinson, S.R., Evans, M.H., Groves, F., A neurotoxic component of the venom from Blanding's tree snake (Boiga blandingi) (1976) Toxicon, 14, pp. 307-312
dc.descriptionPhisalix, M., (1922) Animaux Venimeaux et Venins, 2, pp. 385-395. , Paris: Masson
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dc.descriptionWeinstein, S.A., Kardong, K.V., Properties of Duvernoy's secretions from opisthoglyphous and aglyphous colubrid snakes (1994) Toxicon, 32, pp. 1161-1185
dc.descriptionWeinstein, S.A., Stiles, B.G., McCoide, M.J., Smith, L.A., Kardong, K.V., Variation of lethal potencies and acetylcholine receptor binding activity of Duvernoy's secretion from brown tree snake, Boiga irregularis Merrem (1993) J. Nat. Toxins, 2, pp. 187-198
dc.languageen
dc.publisher
dc.relationToxicon
dc.rightsfechado
dc.sourceScopus
dc.titleMode Of Action Of Duvernoy's Gland Extracts From The Colubrid Dryadophis Biofossatus In The Chick Biventer Cervicis Nerve-muscle Preparation
dc.typeArtículos de revistas


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