Artículos de revistas
Chromobacterium Violaceum: A Review Of Pharmacological And Industiral Perspectives
Registro en:
Critical Reviews In Microbiology. , v. 27, n. 3, p. 201 - 222, 2001.
2-s2.0-0034805976
Autor
Duran N.
Menck C.F.M.
Institución
Resumen
Violet-pigmented bacteria, which have been described since the end of the 19th century, are occasionally the causative agent of septicemia and sometimes cause fatal infection in human and animals. Bacteria, producing violet colonies due to the production of a nondiffusible pigment violacein, were classified as a redefined genus Chromobacterium. Chromobacterium violaceum is Gram-negative, and saprophyte from soil and water is normally considered nonpathogenic to human, but is an opportunistic pathogen of extreme virulence for human and animals. The biosynthesis and biological activities of violacein and the diverse effects of this pigment have been studied. Besides violacein, C. violaceum produces other antibiotics, such as aerocyanidin and aerocavin, which exhibit in vitro activity against both Gram-negative and Gram-positive bacteria. 3,6-Dihydroxyindoxazene and Y-TO678h exhibit a selective activity against Gram-negative bacteria. Arphamenine A and B, and FR901228, that enhanced immunoresponse, and potentiators of β-lactam antibiotics and chelators such as ferrioxamine exhibit important clinical potential applications. Lipopolysaccharides and polyhydroxyesters together with several enzymes appear as important metabolites with biotechnological applications. Many of these metabolites were already studied at the genome level. 27 3 201 222 Aldridge, K.E., Valainis, G.T., Sanders, C.V., Comparison of the in vitro of citoprofloxacin and 24 other antimicrobial agents against clinical strains of Chromobacterium violaceum (1988) Diagnostic Microbiol. Infect. Dis., 10, pp. 31-39 Antônio, R.V., (1994) Violacein biosynthesis by Chromobacterium violaceum: Synthesis and biological activities of a probable intermediate, , (Durán, N. and Haun, M. Supervisors), Ph.D. Dissertation, Biology Institute, Universidade Estadual de Campinas, Brazil Audebaud, G., Ganzin, M., Ceccaldi, J., Merveille, P., Isolement dun Chromobacterium violaceum a partir de lessions hepatiques observees chez un singe Cercopithecus cephus etude et pouvoir pathogene (1954) Ann. L'Institute Pasteur., 87, pp. 413-417 August, P.R., Grossman, T.H., Minor, C., Draper, M.P., MacNeil, I.A., Pemberton, J.M., Call, K.M., Osburne, M.S., Sequence analysis and functional characterization of the violacein biosynthetic pathway from Chromobacterium violaceum (2000) J. Mol. Microbiol. Biotechnol., 2, pp. 513-519 August, P.R., Grossman, T.H., Minor, C., Draper, M.P., MacNeil, I.A., Pemberton, J.M., Call, K.M., Osburne, M.S., Hydroxylases VioABCD in Chromobacterium violaceum (2000) NCBI-Protein, , AAD51809-51811 Bachofen, R., Schenk, A., Quorum sensing autoinducers: Do they play a role in natural microbial habitats? (1998) Microbiol. Res., 153, pp. 61-63 Ballantine, J.A., Beer, R.J.S., Crutchley, D.J., Dodd, G.M., Palmer, D.R., The synthesis of violacein and related compounds (1958) J. Chem. Soc., pp. 232-233 Ballantine, J.A., Beer, R.J.S., Crutchley, D.J., Dodd, G.M., Palmer, D.R., The chemistry of bacteria. Part VIII. The synthesis of violacein and related compounds (1960) J. Chem. Soc., pp. 2292-2299 Balows, A., Truper, H.G., Dworkin, M., Harder, W., Schleifer, K.H., (1992) The prokaryots, 2nd. ed., 3. , Springer-Verlag, N.Y Bazylinski, D.A., Palome, E., Blakemore, N.A., Blakemore, R.P., Denitrification by Chromobacterium violaceum (1986) Appl. Environ. Microbiol., 52, pp. 696-699 Beinert, H., Copper in biological system. A report from 6th. Manziana Conference (1991) J. Inorg. Biochem., 44, pp. 173-218 Lee, J., Kim, J.S., Nahm, C.H., Choi, J.W., Kim, J., Pai, S.H., Moon, K.H., Chong, Y., Two cases of Chromobacterium violaceum infection after injury in a subtropical region (1999) J. Clin. Microbiol., 37, pp. 2068-2070 Letendre, C.H., Dickens, G., Guroff, G., Tryptophan hydroxylase of Chromobacterium violaceum (1974) J. Biol. Chem., 249, pp. 7186-7191 Li, K.W., Wu, J., Xing, W.N., Simon, J.A., Total synthesis of the antitumor depsipeptide FR-901,228 (1996) J. Am. Chem. Soc., 118, pp. 7237-7238 Lichstein, H.C., Van de Sand, V.F., Violacein an antibiotic pigment produced by Chromobacterium violaceum (1945) J. Infect. Dis., 76, pp. 47-51 Liebergesell, M., Steinbuchel, A., Steinbuechel, A., Production of poly:hydroxyalkanoate polymer(s) - by culturing Chromatium vinosum or transformants containing C. vinosum PHA biosynthetic genes, Eur. Patent. WO 9302194-A1, 1993Liu, W.C., New aerocavin antibiotic - Is (3E,6E,9E,12 alpha, 14 beta)-12-hydroxy-14-(2-hydroxyundecyl)-10-methyl-2-oxo: oxa:cyclo:tetra:deca-3,6,9-tri:ene-4-acetic acid, US Patent US4686299-A, 1987Liu, C.H., Chu, R.M., Weng, C.N., Lin, Y.L., Chi, C.S., An acute pleuropneumpnia in a pig caused by Chromobacterium violaceum (1989) J. Compar. Pathol., 100, pp. 459-463 Macadam, A.M., Knowles, C.J., Purification and properties of β-cyano-L-alanine synthase from the cyanide producing bacterium Chromobacterium violaceum (1984) Biochim. Biophys. Acta., 786, pp. 123-132 Macher, A.M., Casale, T.B., Fauci, A.S., Chronic granulomatous disease of childhood and Chromobacterium violaceum infections in the southeastern (1982) Ann. Intern. Med., 97, pp. 51-55 Macher, A.M., Casale, T.B., Gallin, J.I., Boltansky, H., Fauci, A.S., Chromobacterium violaceum infectious and chronic granulomatous disease (1983) Ann. Intern. Med., 98, pp. 259-259 Machin-Villafranca, C., Ley, N., Torres-Hernandez, L., Infección por Chromobacterium violaceum. Presentación de un caso com evolución fatal (1986) Rev. Cubana Med. Trop., 38, pp. 353-357 Martin, J., Brimacombe, J., Chromobacterium violaceum septicemia- The intensive care management of 2 cases (1992) Anaethes. Intensive Care, 20, pp. 88-90 Bergonzini, C., Um nuevo bacterio colorato (1881) Ann. Soc. Natural. Modena. Ser. 2, 14, pp. 149-158 May, G., Brummer, B., Ott, H., Purification of the antiviral compound violacein from cultures of Chromobacterium (1991) Ger. Offen., , DE 3935066 Melo, P.S., (1996) Pigments from Chromobacterium violaceum and Serratia marcescens, , (Haun, M, e Durán, N., Supervisors), M.Sc. Thesis, Institute of Biology, Universidade Estadual de Campinas, Brazil Melo, P.S., Haun, M., Durán, N., In vitro evaluation of violacein toxicity in different cell lines (1996) Proc. VII Panamerican Associastion of Biochemistry and Molecular Biology-PABMB, , Chile Melo, P.S., Maria, S.S., Vidal, B.C., Haun, M., Durán, N., Violacein cytotoxicity and induction of apoptosis in V79 cells (2000) In vitro Cell. Dev. Biol. Animal, 36, pp. 639-543 Mergaert, J., Schirmer, A., Hauben, L., Mau, M., Hoste, B., Kersters, K., Jendrossek, D., Swings, J., Isolation and identification of poly(3-hydroxyvalerate)-degrading strains of Pseudomonas lemoignei (1996) Intern. J. Syst. Bacteriol., 46, pp. 769-773 McClean, K.H., Winson, M.K., Fish, L., Taylor, A., Chhabra, S.R., Camara, M., Daykin, M., Williams, P., Quorum sensing and Chromobacterium violaceum: Exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones (1997) Microbiology-UK, 143, pp. 3703-3711 McClure, H.M., Chang, J., Chromobacterium violaceum infection in a nonhuman primate (Macaca assamensis) (1976) Lab. Animal Sci., 26, pp. 807-810 Midani, S., Rathore, M., Chromobacterium violaceum infection (1998) Southern Med. J., 91, pp. 464-466 Miller, D.P., Blevins, W.T., Steele, D.B., Stower, M.D., A comparative study of virulent and avirulent strains of Chromobacterium violaceum (1988) Can. J. Microbiol., 34, pp. 249-255 Momen, A.Z.M.R., Hoshino, T., Biosynthesis of violacein: Intact incorporation of the tryptophan molecule on the oxindole side, with intramolecular rearrangement of the indole ring on the 5-hydroxyindole side (2000) Biosci. Biotechnol. Biochem., 64, pp. 539-549 Blereau, R.P., Septicemia and death caused by Chromobacterium violaceum (1980) Southern Med. J., 73, pp. 1093-1094 Momen, A.Z.M.R., Mizuoka, T., Hoshino, T., Studies on the biosynthesis of violacein. Part 9. Green pigments possessing tetraindole and dipyrromethene moieties, chromoviridans and deoxychromoviridans, produced by a cell-free extract of Chromobacterium violaceum and their biosynthetic origins (1998) J. Chem. Soc. Perkin Trans. 1, pp. 3087-3092 Mueller, A., Zaehner, H., Metabolic products of microroganisms LXV. Ferrioxamines for Eubacteriales (1968) Arch. Microbiol., 62, pp. 257-260 Murata, M., Towatari, M., Kosugi, H., Tanimoto, M., Ueda, R., Saito, H., Naoe, T., Apoptotic cytotoxic effects of a histone deacetylase inhibitors, FK228, on malignant lymphoid cells (2000) Jpn. J. Cancer Res., 91, pp. 1154-1160 Nakajima, H., Kim, Y.B., Terano, H., Yoshida, M., Horinouchi, S., FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor (1998) Experiment. Cell Res., 241, pp. 126-133 Nakata, H., Yamauchi, T., Fujisawa, H., Phenylalanine hydroxylase from Chromobacterium violaceum, purification and characterization (1979) J. Biol. Chem., 254, pp. 1829-1833 Ognibene, A.J., Thomas, E., Fatal infection due to Chromobacterium violaceum in Vietnam (1970) Am. J. Clin. Pathol., 54, pp. 607-612 Ohuchi, S., Okuyama, A., Naganawa, H., Kawamura, K., Aoyagi, T., Umezawa, H., Isolation of two intermediates of arphamenine B biosynthesis (1997) Chem. Abstr., 106, pp. 172-650. , Meiji Seika Kenkyu Nenpo. 24, 44-47, 1985 Onile, A., Sobowale, B.O., Odugbemi, T., Human infection due to Chromobacterium violaceum. A report from Ilorin, Nigeria (1984) East Afr. Med. J., 61, pp. 849-852 Onishi, A., Liotta, L.J., Benkovic, S.J., Cloning and expression of Chromobacterium violaceum phenylalanine hydroxylase in Escherichia coli and comparison of amino acid sequence with mammalian aromatic amino acid hydroxylases (1991) J. Biol. Chem., 266, pp. 18454-18459 Onishi, A., Liotta, L.J., Benkovic, S.J., Chromobacterium violaceum phenylalanine hydroxylase gene, complete cds (1991) NCBI-Protein, , P30967 Bilton, B.D., Johnson, L.W., Recurrent nonfatal Chromobacterium violaceum infection in a nonimmunocompromised patient (2000) Infect. Med., 17, pp. 686-690 A40996 AAA23115 M55915 Parker, W.L., Rathnum, M.L., Johnson, J.H., Wells, J.S., Principe, P.A., Sykes, R.B., Aerocyanidin, a new antibiotic produced by Chromobacterium violaceun (1988) J. Antibiotics, 41, pp. 454-460 Pember, S.O., Johnson, K.A., Villafranca, J.J., Benkovic, S.J., Mechanistic studies on phenylalanine hydroxylase from Chromobacterium vlaceum. Evidence for the formation of an enzyme-oxygen complex (1989) Biochemistry, 28, pp. 2124-2130 Pember, S.O., Villafranca, J.J., Benkovic, S.J., Chromobacterium violaceum phenylalanine 4-monooxygenase (1987) Methods Enzymol., 142, pp. 50-56 Perberton, J.M., Vincent, K.M., Penfold, R.J., Cloning and heterologous expression of the violacein biosynthesis gene cluster from Chromobacterium violaceum (1991) Curr. Microbiol., 22, pp. 355-358 Petrillo, V.F., Severo, V., Santos, M.M., Edelweiss, E.L., Recurrent infection with Chromobacterium violaceum: First case report from South America (1984) J. Infect., 9, pp. 167-169 Ponte, R., Jenkins, S.G., Fatal Chromobacterium violaceum infections associated with exposure to stagnant water (1992) Pediatr. Infect. Dis., 11, pp. 583-586 Reilly, J., Pyne, G., CXL. On the pigment produced by Chromobacterium violaceum (1927) Biochem. J., 21, pp. 1059-1064 Blosser, R.S., Gray, K.M., Extraction of violacein from Chromobacterium violaceum provides a new quantitative bioassay for N-acyl homoserine lactone autoinducers (2000) J. Microbiol. Methods, 40, pp. 47-55 Ressler, C., Abe, O., Kondo, Y., Cottrell, B., Abe, K., Purification and characterization from Chromobacterium violaceum of an enzyme catalyzing synthesis of γ-cyanoα-aminobutyric acid and thiocyanate (1973) Biochemistry, 12, pp. 5369-5377 Rettori, D., (1996) Production, extraction and purification of violacein: An antibiotic produced by Chromobacterium violaceum, , (Durán, N., Supervisor), M.Sc. Thesis, Chemistry Institute, Universidade Estadual de Campinas, Brazil Rettori, D., (2000) Physico-chemical and biological studies of violacein: A pigment produced by Chromobacterium violaceum, , (Durán, N., Supervisor), Ph.D. Dissertation, Chemistry Institute, Universidade Estadual de Campinas, Brazil Rettori, D., Durán, N., Stationary tray bioreactor for bacterial metabolites production, Brazilian Patent, PIBr 9702986-6, 1997Rettori, D., Durán, N., Production, extraction and purification of violacein: An antibiotic produced by Chromobacterium violaceum (1998) World. J. Microbiol. Biotechnol., 14, pp. 685-688 Richards, C., Chromobacterium violaceum, opportunistic pathogenic bacteria isolated in tropical and subtropical areas (1993) Bull. Soc. Pathol. Exotique, 86, pp. 169-173 Richards, C., Chromobacterium violaceum, opportunistic pathogenic bacteria isolated in tropical and subtropical areas (1993) Bull. Soc. Pathol. Exotique, 86, pp. 307-307 Riveros, R., (1986) Chemistry and biological activity of 1,3-dihydro-2H-indole-2-one derivatives, , (Durán, N., Supervisor), M.Sc. Thesis, Chemistry Institute, Universidade Estadual de Campinas, Brazil Riveros, R., (1989) Bacterial chemistry: Biosynthesis and biological activity of Chromobacterium violaceum metabolites, , (Durán, N., Orientador), Ph.D. Dissertation, Chemistry Institute, Universidade Estadual de Campinas Riveros, R., Haun, M., Campos, V., Durán, N., Bacterial chemistry-IV: Total characterization of violacein. An antibiotic trypanocide from Chromobacterium violaceum (1988) Arq. Biol. Tecnol., 31, pp. 475-487 Riveros, R., Haun, M., Durán, N., Bacterial chemistry-V: Effect of growth conditions on production of violascein by Chromobacterium violaceum BB-78 strain (1989) Brazilian J. Med. Biol. Res., 22, pp. 569-577 Boisbaudran, L., Matière colorante se formant dans la colle de farine (1882) Comp. Rend. Acad. Sci., 94, pp. 562-563 Roberts, S.A., Morris, A.J., McIvor, N., EllisPegler, R., Chromobacterium violaceum infection of the deep neck tissues in a traveler to Thailand (1997) Clin. Infect. Dis., 25, pp. 334-335 Sandor, V., Senderowicz, A., Mertins, S., Sackett, D., Sausville, E., Blagosklonny, M.V., Bates, S.E., P21-dependent G(1) arrest with downregulation of cyclin D1 and upregulation od cyclin E by the histone deacetylase inhibitor FR901228 (2000) Br. J. Cancer, 83, pp. 817-825 Sandor, V., Robbins, A.R., Robey, R., Myers, T., Sauville, E., Bates, S.E., Sackett, D.L., FR901228 causes mitotic arrest but does not alter microtubule polymerization (2000) Anti-Cancer Drugs, 11, pp. 445-454 Shigematsu, N., Ueda, H., Takase, S., Tanaka, H., Yamamoto, K., Tada, T., FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum N°-968.2. Structure determination (1994) J. Antibiotics, 47, pp. 311-314 Shirata, A., Tsukamoto, T., Yasui, H., Hata, T., Hayasaka, S., Kojima, A., Kato, H., Isolation of bacteria producing bluish-purple pigment and use for dyeing (2000) Japan Agric. Res. Quart., 34, pp. 131-140 Shirazi-Beechey, S.P., Sraya, P., Knowles, C.J., Serine hydroxymethyltransferase and glycine cleavage enzyme from the cyanogenic bacterium Chromobacterium violaceum (1984) J. Gen. Microbiol., 130, pp. 521-525 Sherwood, M., Bacterial plastic comes to market (1983) Bio/Technology., 1, pp. 388-389 Simo, F., Reuman, P.D., Martinez, F.J., Ayoub, E.M., Chromobacterium violaceum as a cause of periorbital cellulitis (1984) Pediatr. Infect. Dis. J., 3, pp. 561-563 Singh, P.D., Liu, W.C., Gougoutas, J.Z., Malley, M.F., Porubcan, M.A., Trejo, W.H., Wells, J.S., Sykes, R.B., Aerocavin, a new antibiotic produced by Chromobacterium violaceum (1988) J. Antibiotics, 41, pp. 446-453 Sippel, W.L., Medina, G., Atwood, M.B., Outbreaks of disease in animals associated with Chromobacterium violaceum. 1. The disease in swine (1954) I. Am. Veter. Med. Assoc., 124, pp. 467-471 Bromberg, N., (2000) Violacein biotransformations, , (Durán, N., Supervisor). M.Sc. Thesis, Chemistry Institute, Universidade Estadual de Campinas, Brazil Sivendran, R., Tan, S.H., Pathogenicity of nonpigmented cultures of Chromobacterium violaceum (1977) J. Clin. Microbiol., 5, pp. 514-516 Smith, A.D., Hunt, R.J., Solubilization of gold by Chromobacterium violaceum (1985) J. Chem. Technol. Biotechnol. B. Biotechnol., 35, pp. 110-116 Sneath, P.H.A., Whelan, J.P.F., Singh, R.B., Edwards, D., Fatal infection by Chromobacterium violaceum (1953) Lancet, 265, pp. 276-277 Snowe, R.J., Chromobacrterium violaceum, pathogenic for man (1971) J. Infect. Dis., 123, pp. 226-229 Sorensen, I.R.U., Jacobs, M.R., Shurin, S.B., Chromobacterium violaceum adenitis acquired in the northern United States as complication if chronic granulomatous disease (1985) Pediat. Infect. Dis. J., 4, pp. 701-702 Starr, A.J., Cribbett, L.S., Poklepovic, J., Freidman, H., Ruffolo, E.H., Chromobacterium violaceum presenting as a surgical emergency (1981) Southern Med. J., 74, pp. 1137-1139 Stenbuchel, A., Debzi, E.M., Marchessault, R.H., Timm, A., Synthesis and production of poly(3-hydroxyvaleric acid) homopolyester by Chromobacterium violaceum (1993) Appl. Microbiol. Biotechnol., 39, pp. 443-449 Steibuchel, A., Schmack, G., Large-scale production of poly (3-hydrovaleric acid) by fermentation of Chromobacterium violaceum, processing, and characterization of the homopolyester (1995) J. Environ. Polym. Degrad., 3, pp. 243-258 Ti, T.Y., Tan, W.C., Chong, A.P.Y., Lee, E.H., Nonfatal and fatal infections caused by Chromobacterium violaceum (1993) Clin. Infect. Dis., 17, pp. 505-507 Tobie, W.C., The pigment of Bacillus violaceus I. The production, extraction, and purification of violacein (1934) J. Bacteriol., 29, pp. 223-227 Buchanan, E., Studies in the nomenclature and classification of the bacteria (1918) J. Bacteriol., 3, pp. 52-57 Tucker, R.E., Winter, W.G., Wilson, H.D., Osteomyelitis associated with Chromobacterium violaceum sepsis-case-report (1979) J. Bone Joint Sur. Am., 61, pp. 949-951 Turner, S.J., Lewis, G.D., Saul, D.J., Baker, C.S., Rodrigo, A.G., Chromobacterium violaceum 16S ribosomal RNA gene, partial sequence spanning the V3-V4 regions (1996) NCBI-Nucleotide, , U65966 Ueda, H., Nakajima, H., Hori, Y., Fujita, T., Nishimura, M., Goto, T., Okuhara, M., FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum N°968. 1. Taxonomy, fermentation, isolation, physicochemical and biologi Byrd, J.C., Shinn, C., Ravi, R., Willis, C.R., Waselenko, J.K., Flinn, I.W., Dawson, N.A., Grever, M.R., Depsipeptide (FR901228): A novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells (1999) Blood, 94, pp. 1401-1408 Byrd, J.C., Waselenko, J.K., Keating, M., Rai, K., Grever, M.R., Novel therapies for chronic lymphocytic leukemia in the 21st century (2000) Seminar Oncol., 27, pp. 587-597 Caldas, L.R., Photochemistry and photobiology in a virgin land (1977) Photochem. Photobiol., 26, pp. 1-2 Caldas, L.R., Um pigmento nas águas negras (1990) Ciência Hoje, 11, pp. 56-57 Caldas, L.R., Leitao, A.A.C., Santos, S.M., Tyrrell, R.M., Preliminary experiments on the photobiological properties of violacein (1978) Intern. Symp. Curr. Topics Radiol. Photobiol. Acad. Brasil. Cienc., pp. 121-132. , Rio de Janeiro Carrasco, L., Astorga, R., Mendez, A., Maldonado, A., Barazona, J., Perea, A., Acute pleuropneumonia in Barbary sheep (Amnotragus lervia) asociated with Chromobacterium violaceum (1996) Veterin. Record., 138, pp. 499-500 Cha, C., Gao, P., Chen, Y.C., Shaw, P.D., Farrand, S.K., Production of acyl-homoserine lactone quorum-sensing signals by Gram-negative plant-associated bacteria (1998) Mol. Plant Microbe Interact., 11, pp. 1119-1129 Chong, C.Y., Lam, M.S., Case report and review of Chromobacterium sepsis-a Gram negative sepsis mimicking melioidosis (1997) Singapore Med. J., 38, pp. 263-265 Cheah, E., MacPherson, K., Quiggin, D., Keese, P., Ollis, D.L., Crystallization and preliminary X-ray analysis of IND, an enzyme with indole oxygenase activity from Chromobacterium violaceum (1998) Acta Crystl. Sec. D. Biol. Crystal., 54, pp. 657-658 Chen, D.W., Frey, P.A., Phenylalanine hydroxylase from Chromobacterium violaceum. Uncoupled oxidation of tetrahydropterin and the role of iron in hydroxylation (1998) J. Biol. Chem., 273, pp. 25594-25601 Chernin, L.S., Winson, M.K., Thompson, J.M., Haran, S., Bycroft, B.W., Chet, I., Williams, P., Stewart, G.S.A.B., Chitinolytic activity in Chromobacterium violaceum: Substrate analysis and regulation by quorum sensing (1998) J. Bacteriol., 180, pp. 4435-4441 Christian, M.C., Pluda, J.M., Ho, P.T.C., Arbuck, S.G., Murgo, A.J., Sausville, E.A., Promising new agents under development by the division of cancer treatment, diagnosis, and centers of the National Cancer Institute (1997) Seminars Oncol., 24, pp. 219-240 Cimarusti, C., Floyd, D.M., Fritz, A.W., Parker, W.L., Stusarchyk, W.A., Sykes, R.B., US Patent. US4386034-A, 1983Collins, B., Kollias, G., Battles, A., Moreland, A., Chromobacterium violaceum infection in a stumptailed monkey (Macaca artoices) (1985) Lab. Animal Sci., 35, pp. 530-531 Cooper, R., Wells, J.S., Sykes, R.B., Novel potentiators of β-lactam antibiotics. Isolation of SQ28,504 and SQ28,546 from Chromobacterium violaceum (1985) J. Antibiotics, 38, pp. 449-454 Cooper, R., Sykes, R.B., Wells, J.S., New compounds, SQ28504 and SQ28546 - enhance antibacterial activity of beta-lactam antibiotics SQ28546, US Patent US4752469-A, 1984De Azevedo, M.B.M., Alderete, J., Lino, A.C.S., Loh, W., Faljoni-Alario, A., Durán, N., Violacein/cyclodextrin inclusion complex by diffusion coefficient and circular dichroism measurements (2000) J. Inclusion Phenom. Mol. Recognit. Chem., 37, pp. 67-74 De Azevedo, M.B.M., Alderete, J., Rodriguez, J.A., De Souza, A.O., Faljoni-Alario, A., Durán, N., Biological activities of new antitumoral of indole derivatives in a inclusion complex with cyclodextrin (2000) J. Inclusion Phenom. Mol. Recognit. Chem., 37, pp. 93-101 De Azevedo, M.B.M., Justo, G.Z., Rettori, D., Rodriguez, J.A., Haun, M., Durán, N., Antioxidant activity of an inclusion complex of violacein and β-cyclodextrin (2000) Proc. Intern. Symp. Control. Rel. Bioact. Mater., 27, pp. 506-507 De Azevedo, M.B.M., Melo, P.S., Almeida, A.B.A., Souza-Brito, A.R.M., Haun, M., Durán, N., Antiulcerogenic activity of violacein/cyclodextrin inclusion complexes and violacein (2000) Proc. Intern. Symp. Control. Rel. Bioact. Mater., 27, pp. 508-509 De Moss, R.D., Violacein (1967) Antibiotics, 2, pp. 77-81 De Moss, R.D., Evans, N.R., Physiological aspects of violacein biosynthesis in nonproliferating cells (1959) J. Bacteriol., 78, pp. 583-588 De Moss, R.D., Evans, N.R., Incorporation of C14-labeled substrates into violacein (1960) J. Bacteriol., 79, pp. 729-733 De Souza, A.O., Aily, D.C.G., Sato, D.N., Durán, N., Atividade da violaceina in vitro sobre o Mycobacterium tuberculosis H37RA (1999) Rev. Inst. Adolfo Lutz., 58, pp. 59-62 Dewhirst, F.E., Paster, B.J., Bright, P.L., Chromobacterium, Eikenella, Kingella, Neisseria, Simonsiella, and Vitreoscilla species comprise a major branch of the beta group proteobacteria by 16S ribosomal ribonucleic acid sequence comparison: Transfer of Eikenella and Simonsiella to the family Neisseriaceae (emend.) (1989) Intern. J. System. Bacteriol., 39, pp. 258-266 Dewhirst, F.E., Paster, B.J., Bright, P.L., Chromobacterium violaceum 16S ribosomal RNA, complete cds (1989) NCBI-Nucleotide, , M22510 Durán, N., Violaceina: A descoberta de um antibiótico (1990) Ciencia Hoje, 11, pp. 58-80 Durán, N., Antonio, R.V., Haun, M., Pilli, R.A., Biosynthesis of trypanocide by Chromobacterium violaceum (1994) World J. Microbiol. Biotechnol., 10, pp. 686-690 Durán, N., Bromberg, N., Violacein transformation by peroxidase and oxidases: Implications on its biological properties (2001) J. Mol. Catalysis B. Enzym., 11, pp. 463-467 Durán, N., De Azevedo, M.B.M., Alderete, J., Formulation process of cyclodextrin/violacein for using as antibacterial, antitumoral, antiviral and trypanocide, Brazilian Patent PIBr 9801307, 1998Durán, N., De Conti, R., Sato, L.M., Jardim, L.S.A., Moraes, S.G., Process for the synthesis of indole-glycosides, Brazilian Patent. PIBr. 9702822, 1997Durán, N., Erazo, S., Campos, V., Bacterial chemistry-II: Antimicrobial photoproduct from pigment of Chromobacterium violaceum (1983) An. Acad. Brasil. Cienc., 55, pp. 231-234 Durán, N., Campos, V., Riveros, R., Joyas, A., Pereira, M.F., Haun, M., Bacterial chemistry. III. Preliminary studies on trypanosomal activities of Chromobacterium violaceum products (1989) An. Acad. Brasil. Sci., 61, pp. 31-36 Durán, N., Faljoni-Alario, A., Bacterial chemistry-I: Studies of a potential phototherpaeutic substance from Chromobacterium violaceum (1980) An. Acad. Brasil. Ciênc., 52, pp. 297-302 Durán, N., Haan, M., Trypanocide. State of art (1991) Mem. Inst. Oswaldo Cruz. SUPPL. I, 86, pp. 29-30 Durán, N., Haun, M., Production process of preparation and purification of antitumoral 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]- 1,3-dihydro-2H-indol-2-one, Brazilian Patent PIBr. 9702918, 1997Durán, N., Jardim, L.M., Moraes, S.G., De Conti, R., Nuevo metodo de sintesis de N-indol-glicosideos com actividad antimicrobiana (1998) Rev. Soc. Quim. Chile, 43, pp. 91-96 Durán, N., Melo, P.S., Haun, M., Violacein in an investigational AIDS-related lymphoma screen in vitro (1996) Proc. VIII National Meeting of Virology, H54, p. 179. , São Lorenço, M.G. Brazil Durán, N., Melo, P.S., Haun, M., In vitro evaluation of violacein on AIDS-related lymphoma and human tumor cells lines (1996) XXI National Meeting Biochemical Society-SBBq, p. 24. , Caxambu, M.G. Brazil Durán, N., Riveros, R., Haun, M., Da Silva, L.P., Hoffman, M.E., Dawood, F.A.M., Pizani, O.D.S., Joyas, A., Chemistry, biochemistry and clinical aspects of a microbiological new compounds (1988) Proc. VI Bioorganic Workshop (Brazil-Chile), pp. 14-16. , Santiago, Chile Durán, N., De Souza, A.O., Process for the violacein application as antimycobacterial agent, Brazilian Patent. PIBr, in press, 2001Farrar, W.E., O'Dell, N.M., β-lactamase activity in Chromobacterium violaceum (1976) J. Infect. Dis., 134, pp. 290-293 Farrell, K., Vanwerkhooven, M., Gratten, M., Aiken, G.H., Chromobacterium violaceum infection: Report of a fatal case (1979) Papua New Guinea Med. J., 22, pp. 94-95 Feldman, R.B., Stern, G.A., Hood, C.I., Chromobacterium violaceum infection of the eye: A report of 2 cases (1984) Arch. Ophthalmol., 102, pp. 711-713 Fujisawa, H., Nakata, H., Phenylalanine 4-monooxygenase from Chromobacterium violaceum (1987) Methods Enzymol., 142, pp. 44-49 Fujita, T., Goto, T., Hori, Y., Okuhara, M., Shigematsu, N., Ueda, H., New antibiotic substance for FR901228 obtained by culture of Chromobacterium violaceum WB 968, and biologically pure culture of this microorganism, Eur. Patent EP352646-A US4977138A, 1990Fombuena, M., Ballester, J.E., Pedro, F., Garcia del Toro, M., Herrera Ballester, A., Infection by Chromobacterium violaceum in a patient with acquire immunodeficiency virus infection (1998) Enferm. Infect. Microbiol. Clin., 16, pp. 46-47 Gaeumann, E., Prelog, V., Bickel, H., Vischer, E., Growth accelerators, ferrioxamine, Ger Patent. Ger 1123436, 1962Genet, R., Benetti, P.H., Hammadi, A., Menez, A., L-Tryptophan 2′,3′-oxidase from Chromobacterium violaceum (1995) J. Biol. Chem., 270, pp. 23540-23545 Geoghiou, P.R., Okane, G.M., Siu, S., Kemp, R.J., Near-fatal septicemia with Chromobacterium violaceum (1989) Med. J. Austr., 150, pp. 720-721 Gillis, M., De Ley, J., The genera Chromobacterium and Janthinobacterium (1992) The Prokaryotes, 2nd ed., 3, pp. 2591-2600. , (Ballow, A., et al., Eds.) Springer-Verlag, N.Y., Chap. 133 Gogolewski, R.P., Chromobacterium violaceum septicemia in a dog (1983) Austr. Veter. J., 60, pp. 226-226 Gourson, C., Benhaddou, R., Granet, R., Krausz, P., Verneuil, B., Branland, P., Chauvelon, G., Saulnier, L., Valorization of maize bran to obtain biodegradable plastic films (1999) J. Appl. Poly. Sci., 74, pp. 3040-3045 Groves, M.G., Strauss, J.M., Abbas, J., Davis, C.E., Natural infections of Gibbons with s bacterium producing violet pigment (Chromobacterium violaceum) (1969) J. Infect. Dis., 120, pp. 605-607 Hamada, M., Kondo, S., Nakamura, H., Ikeda, T., Ikeda, D., Iinuma, K., Gomi, S., Takuchi, T., A new antibiotic, 3,6-dihydroxyundoxazene (1983) J. Antibiotics, 36, pp. 445-447 Hammadi, A., Menez, A., Genet, R., Asymmetric deuteration of N-acetyl-(Z)-α, β-dehydrotryptophan-(L)-phenylalanine methyl ester produced by (L)-tryptophan 2′,3′-oxidase from Chromobacterium violaceum. A new route for stereospecific labelling of peptides (1997) Tetrahedron, 53, pp. 16115-16122 Hassan, H., Suntharalingam, S., Dhillon, K.S., Fatal Chromobacterium violaceum septicemia (1993) Singapore Med. J., 34, pp. 456-458 Harmsen, D., Singer, C., Chromobacterium violaceum 16S and 23S rRNA gene (1999) NCBI-Nucleotide, , AF124618 AJ247211 Haun, M., Pereira, M.F., Hoffman, M.E., Joyas, A., Campos, V., Filardi, L.D., De Castro, S.L., Durán, N., Bacterial chemistry. VI. Biological activities and cytotoxicity of 1,3-dihydro-2H-indol-2-one derivatives (1992) Biol. Res., 25, pp. 21-25 Higaki, T., Nagao, K., Isogo, S., Kanda, M., Fujita, K., Yamashita, M., Antitumoric antibiotic WB968 manufacture with Chromobacterium (1998) Chem. Abstr., 126, pp. 250-252. , Jpn. Kokai Tokkyo Koho. JP. 090311088 A2, 1997 Hiraoka, N., Yoshioka, K., Inoue, K., Kawahito, Y., Kasamatsu, Y., Chromobacterium violaceum sepsis accompanied by bacteria-associated hemophagocytic syndrome in a Japanese man (1999) Arch. Intern. Med., 159, pp. 1623-1624 Holt, J.G., Krieg, N.R., (1984) Bergey's Manual of Systematic Bacteriology, 1, pp. 580-582. , Williams & Wilkins, Baltimore Hoshino, T., Chromobacterium violaceum-violacein biosynthetic gene cluster (VioABCD) (1999) NCBI-Protein, , BAA84782-84785 AF172851 AB032799 Hoshino, T., Kondo, T., Uchiyama, T., Ogasawara, N., Biosynthesis of violacein: A novel rearrangement in tryptophan metabolism with a 1,2-shift of the indole ring (1987) Agric. Biol. Chem., 51, pp. 965-968 Hoshino, T., Takano, T., Hori, S., Ogasawara, N., Biosynthesis of violacein: Origins of hydrogen, nitrogen and oxygen atoms in the 2-pyrrolidone nucleous (1987) Agric. Biol. Chem., 51, pp. 2733-2741 Hoshino, T., Kojima, Y., Hayashi, T., Uchiyama, T., Kaneko, K., A new metabolite of tryptophan, chromopyrrolic acid, produced by Chromobacterium violaceum (1993) Biosci. Biotechnol. Biochem., 57, pp. 775-781 Hoshino, T., Hayashi, T., Odajima, T., Biosynthesis of violacein. 1. Oxygenation at the 2-position of the indole ring and structures of proviolacein, prodeoxyviolacein and pseudoviolacein, the plausible biosynthetic intermediates of violacein and deoxyviolacein (1995) J. Chem. Soc. Perkin Trans. 1, pp. 1565-1571 Hoshino, T., Ogasawara, N., Biosynthesis of violacein: Evidence for the intermediacy of 5-hydroxy-L-tryptophan and structure of a new pigment, oxyviolacein, produced by the metabolism of 5-hydroxytryptophan (1990) Agric. Biol. Chem., 54, pp. 2339-2346 Hoshino, T., Hayashi, T., Uchiyama, T., Pseudodeoxyviolacein, a new red pigment produced by tryptophan metabolism of Chromobacterium violaceum (1994) Biosci. Biotechnol. Biochem., 58, pp. 279-282 Hoshino, T., Kimura, K., Takahashi, H., Uchiyama, T., Yoshihama, M., New bis: Indole-pyrrole derivatives obtained from Chromobacterium violaceum - Has good antitumor and antimicrobial properties, and low toxicity, Eur. Pat. Appl. EP612, 742, 1994Huffam, S.E., Nowotny, M.J., Currier, B.J., Chromobacterium violaceum in tropical northern Australia (1998) Med. J. Austr., 168, pp. 335-337 Huisman, G.W., Peoples, O.P., Skraly, F., Microbes with polyhydroxyalkanoates (PHA) biosyntheis genes integrated into their chromosome and method for producing PHAs and screening for PHA genes (2000) Chem. Abstr., 132, pp. 205-399. , PCT Int. Appl. WO 2000011188 A1, 2000 Johnson, W.M., Disalvo, A.F., Steuer, R.R., Fatal Chromobacterium violaceum septicemia (1971) Am. J. Clin. Pathol., 56, pp. 400-403 Kaufman, S.C., Ceraso, D., Schugurensky, A., First case report from Argentina of fatal septicemia caused by Chromobacterium violaceum (1986) J. Clin. Microbiol., 23, pp. 956-958 Kim, T.H., Yu, T.S., Chemical modification of extracellular cytosine deaminase from Chromobacterium violaceum YK 391 (1998) J. Microbiol. Biotechnol., 8, pp. 581-587 Kleid, D.G., Kohr, W.J., Thibodeau, F.R., Recovering gold from gold ore or carbonaceous gold, using microorganisms which produce cyanide ion or which degrade cyanide ion (1997) Chem. Abstr., 115, pp. 187-196. , Can. Pat. Appl. CA 2030900 AA, 1991 Kolibachuk, D., Miller, A., Dennis, D., Cloning, molecular analysis, and expression of the polyhydroxyalkanoic acid synthase (phaC) gene from Chromobacterium violaceum (1999) Appl. Environ. Microbiol., 65, pp. 3561-3565 Kolibachuk, D., Dennis, D., Chromobacterium violaceum SoxR homolog gene, complete cds (1998) NCBI-Protein, , AAC69613 AF061445 Kolibachuk, D., Miller, A., Dennis, D., Chromobacterium violaceum polyhydroxyalkanoate synthase (phaC) gene, complete cds 3-ketothiolase (phaA) gene, partial cds and unknown gene (1999) NCBI-Protein, , AAC69614-AAC69616 AF061446 Kornegay, R.W., Pirie, G., Brown, C.C., Newton, J.C., Chromobacteriosis (Chromobacterium violaceum) in a 3 colobus monkeys (Colobus polykomos) (1991) J. Zoo Wildflife Med., 22, pp. 476-484 Kumar, M., Chaturvedi, V.K., Singh, D.P., Chromobacterium violaceum, an unusual pathogen of swine (1999) Indian Veter. J., 76, pp. 869-871 Laatsch, H., Thomson, R.H., Spectroscopic properties of violacein and related compound: Crystal structure of tetramethylviolacein (1984) J. Chem. Soc. Perkin Trans. II, pp. 1331-1339 Lawson, E.N., Barkhuisen, M., Dew, D.W., Gold solubilization by the cyanide producing bacteria Chromobacterium violaceum (1999) Process metall., 9A (Biohydrometallurgy and the Environment Toward the Mining of the 21st Century), (PART A), p. 239