Mdm2+/cdk4+/p53+ Oral Liposarcoma: Case Report And Review Of The Literature

dc.creatorNikitakis N.G.
dc.creatorLopes M.A.
dc.creatorPazoki A.E.
dc.creatorRobert A O.
dc.creatorSauk J.J.
dc.date2001
dc.date2015-06-26T14:43:44Z
dc.date2015-11-26T14:17:08Z
dc.date2015-06-26T14:43:44Z
dc.date2015-11-26T14:17:08Z
dc.date.accessioned2018-03-28T21:18:10Z
dc.date.available2018-03-28T21:18:10Z
dc.identifier
dc.identifierOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, And Endodontics. , v. 92, n. 2, p. 194 - 201, 2001.
dc.identifier10792104
dc.identifier10.1067/moe.2001.116815
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0035433637&partnerID=40&md5=4bc8a61740db39ef340adda96ad79490
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/95152
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/95152
dc.identifier2-s2.0-0035433637
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1243252
dc.descriptionAlthough liposarcoma is one of the most common soft tissue sarcomas, its location in the oral cavity is very rare. To our knowledge, only 43 cases of liposarcoma originating in the oral tissues have been reported in the English-language literature. In this article, we report a case of well-differentiated liposarcoma affecting the cheek of a 28-year-old man and review the oral liposarcoma literature. Immunohistochemical analysis of the tumor revealed an MDM2+/CDK4+/p53+ immunophenotype that is consistent with the immunohistochemical profile of well-differentiated liposarcoma originating in other areas of the body. Quantitative polymerase chain reaction analysis of the DNA levels of the MDM2 (human homologue of the murine double-minute type 2), CDK4 (cyclin-dependent kinase 4), and SAS (sarcoma amplified sequence), genes was performed, revealing only SAS gene amplification. The possibility of misdiagnosis of oral liposarcoma because of its sometimes inconspicuous clinical and microscopic features is emphasized. Careful pathologic examination of liposarcoma is essential for discrimination from benign adipose tissue neoplasms and for precise histologic classification, both of major prognostic significance. Possible implications of molecular and cytogenetic analysis for unraveling the pathogenesis and determining the prognosis of liposarcoma are discussed.
dc.description92
dc.description2
dc.description194
dc.description201
dc.descriptionEnzinger, F.M., Weiss, S.W., Liposarcoma (1995) Soft Tissue Tumors. 3rd Ed., pp. 431-466. , Gay SM, ed. St Louis: Mosby-Year Book
dc.descriptionPack, G.T., Pierson, J.C., Liposarcoma. A study of 105 cases (1954) Surgery, 36, pp. 687-712
dc.descriptionStout, A.P., Liposarcoma - The malignant tumor of lipoblasts (1944) Ann Surg, 119, pp. 86-107
dc.descriptionEnterline, H.T., Culberson, J.D., Rochlin, D.B., Brady, L.W., Liposarcoma. A clinical and pathological study of 53 cases (1960) Cancer, 13, pp. 932-950
dc.descriptionHasegawa, H., Kawakami, T., Eda, S., Mixed-type liposarcoma of the oral cavity: A case with unusual features and a long survival (1999) J Oral Pathol Med, 28, pp. 141-144
dc.descriptionSauk J.J., Jr., Liposarcoma of the head and neck (1971) J Oral Surg, 29, pp. 38-40
dc.descriptionHenefer, E.P., Borghesani, E.P., Sacks, F.R., Liposarcoma of the cheek (1976) J Oral Surg, 34, pp. 1039-1043
dc.descriptionLarson, D.L., Cohn, A.M., Estrada, R.G., Liposarcoma of the tongue (1976) J Otolaryngol, 5, pp. 410-414
dc.descriptionBaden, E., Newman, R., Liposarcoma of the oropharyngeal region. Review of the literature and report of two cases (1977) Oral Surg Oral Med Oral Pathol, 44, pp. 889-902
dc.descriptionRamon, Y., Horowitz, Y., Oberman, M., Freedman, A., Liposarcoma of the buccal mucosa (1977) Int J Oral Surg, 6, pp. 226-228
dc.descriptionAmarjit, S., Singh, A., Nagpal, B.L., Gambir, G.S., Liposarcoma of the cheek (1978) J Oral Surg, 36, pp. 811-813
dc.descriptionHudson, C., Cove, P., Adekeye, E.O., Liposarcoma of the head and neck: Report of case and review of the literature (1978) J Oral Surg, 36, pp. 380-383
dc.descriptionAdkins W.Y., Jr., Putney, F.J., Kreutner, A., Cunningham, C., Liposarcoma of the maxilla (1978) Otolaryngology, 86. , ORL-710-3
dc.descriptionSaunders, J.R., Jaques, D.A., Casterline, P.F., Percarpio, B., Goodloe S., Jr., Liposarcomas of the head and neck: A review of the literature and addition of four cases (1979) Cancer, 43, pp. 162-168
dc.descriptionYamada, K., Dohara, Y., Nagata, M., Kawashima, K., Yamashita, S., A case of liposarcoma of the cheek (1979) Jap J Clin Oncol, 9, pp. 123-130
dc.descriptionAmarjit, S., Bhardwaj, D.N., Nagpal, B.L., Intraosseous liposarcoma of the maxilla and mandible: Report of two cases (1979) J Oral Surg, 37, pp. 593-596
dc.descriptionSadeghi, E.M., Sauk J.J., Jr., Liposarcoma of the oral cavity. Clinical, tissue culture, and ultrastructure study of a case (1982) J Oral Pathol, 11, pp. 263-275
dc.descriptionSuzuki, H., Nagayama, M., Kaneda, T., Oka, T., Liposarcoma of the cheek in an infant (1984) J Oral Maxillofac Surg, 42, pp. 180-184
dc.descriptionWescott, W.B., Correll, R.W., Multiple recurrences of a lesion at the base of the tongue (1984) J Am Dent Assoc, 108, pp. 231-232
dc.descriptionWatanabe, I., Satoh, M., Yamane, G., Horiuchi, T., Shimono, M., Liposarcoma arising from the cheek of the aged: Report of a case and review of the literature (1985) Gerodontics, 1, pp. 148-151
dc.descriptionHanada, M., Tokuda, R., Ohnishi, Y., Takami, M., Takahashi, T., Kimura, M., Benign lipoblastoma and liposarcoma in children (1986) Acta Pathol Jpn, 36, pp. 605-612
dc.descriptionDominguez, F.V., Guglielmotti, M.B., Flores, M.C., De La Garza, M.L.G., Myxoid liposarcoma of the cheek (1990) J Oral Maxillofac Surg, 48, pp. 395-397
dc.descriptionEidinger, G., Katsikeris, N., Gullane, P., Liposarcoma: Report of a case and review of the literature (1990) J Oral Maxillofac Surg, 48, pp. 984-988
dc.descriptionCharnock, D.R., Jett, T., Heise, G., Taylor, R., Liposarcoma arising in the cheek: Report of a case and review of the literature (1991) J Oral Maxillofac Surg, 49, pp. 298-300
dc.descriptionAzaz, B., Casap, N., Myxoid liposarcoma of the buccal vestibule. A case report (1991) Int J Oral Maxillofac Surg, 20, pp. 308-309
dc.descriptionGuest, P.G., Liposarcoma of the tongue: A case report and review of the literature (1992) Br J Oral Maxillofac Surg, 30, pp. 268-269
dc.descriptionRuacan, S., Onerci, M., Gedikoglu, G., Dal, T., Liposarcoma of the cheek: Report of a case (1993) J Oral Pathol Med, 22, pp. 46-47
dc.descriptionLa Quaglia, M.P., Spiro, S.A., Ghavimi, F., Hajdu, S.I., Meyers, P., Exelby, P.R., Liposarcoma in patients younger than or equal to 22 years of age (1993) Cancer, 72, pp. 3114-3119
dc.descriptionLucas, D.R., Nascimento, A.G., Sanjay, B.K.S., Rock, M.G., Well-differentiated liposarcoma. The Mayo Clinic experience with 58 cases (1994) Am J Clin Pathol, 102, pp. 677-683
dc.descriptionZheng, J.W., Wang, Y., Liposarcoma in the oral and maxillofacial region: An analysis of 10 consecutive patients (1994) J Oral Maxillofac Surg, 52, pp. 595-598
dc.descriptionNakahara, H., Shirasuna, K., Terada, K., Liposarcoma of the floor of the mouth: A case report (1994) J Oral Maxillofac Surg, 52, pp. 1322-1324
dc.descriptionMinic, A.J., Liposarcomas of the oral tissues: A clinicopathologic study of four tumors (1995) J Oral Pathol Med, 24, pp. 180-184
dc.descriptionSaddik, M., Oldring, D.J., Mourad, W.A., Liposarcoma of the base of tongue and tonsillar fossa. A possibly underdiagnosed neoplasm (1996) Arch Pathol Lab Med, 120, pp. 292-295
dc.descriptionSenyuva, C., Yucel, A., Okur, I., Dervisoglu, S., A well-differentiated giant liposarcoma originating from the buccal fat pad (1996) Ann Plast Surg, 37, pp. 439-443
dc.descriptionKamikaidou, N., Kirita, T., Mishima, K., Sugimura, M., Liposarcoma of the cheek: Report of a case (1998) J Oral Maxillofac Surg, 56, pp. 662-665
dc.descriptionGovender, D., Pillay, P., Primary myxoid liposarcoma with rhabdomyoblastic differentiation (1998) Arch Pathol Lab Med, 122, pp. 740-742
dc.descriptionNelson, W., Chuprevich, T., Galbraith, D.A., Enlarging tongue mass (1998) J Oral Maxillofac Surg, 56, pp. 224-227
dc.descriptionGagari, E., Kabani, S., Gallagher, G.T., Intraoral liposarcoma: Case report and review of the literature (2000) Oral Surg Oral Med Oral Pathol Radiol Endod, 89, pp. 66-72
dc.descriptionPiattelli, A., Di Alberti, L., Favia, G.F., Liposarcoma involving the periodontal tissues. A case report (2000) J Periodontol, 71, pp. 322-324
dc.descriptionOsborn, M., Iseberg, S., Immunocytochemistry of frozen and of paraffin tissue sections (1994) Cell Biology: A Laboratory Handbook, pp. 361-367. , London: Academic Press
dc.descriptionSambrook, J., Fritsch, E.F., Maniatis, T., (1989) Molecular Cloning: A Laboratory Manual. 2nd Ed., , Nolan C, ed. New York: Cold Spring Harbor Laboratory Press
dc.descriptionGolledge, J., Fisher, C., Rhys-Evans, P.H., Head and neck liposarcoma (1995) Cancer, 76, pp. 1051-1058
dc.descriptionMcCulloch, T.M., Makielski, K.H., McNutt, M.A., Head and neck liposarcoma. A histopathologic reevaluation of reported cases (1992) Arch Otolaryngol Head Neck Surg, 118, pp. 1045-1049
dc.descriptionEnzinger, F.M., Weiss, S.W., Liposarcoma (1988) Soft Tissue Tumors. 2nd Ed., pp. 346-382. , Stamathis G, ed. St. Louis: CV Mosby
dc.descriptionRosai, J., Akerman, M., Dal Cin, P., DeWever, I., Fletcher, C.D., Mandahl, N., Combined morphologic and karyotypic study of 59 atypical lipomatous tumors. Evaluation of their relationship and differential diagnosis with other adipose tissue tumors (1996) Am J Surg Pathol, 20, pp. 1182-1189. , a report of the CHAMP Study Group
dc.descriptionPilotti, S., Della Torre, G., Lavarino, C., Di Palma, S., Sozzi, G., Minoletti, F., Distinct mdm2/p53 expression patterns in liposarcoma subgroups: Implications for different pathogenetic mechanisms (1997) J Pathol, 181, pp. 14-24
dc.descriptionTallini, G., Akerman, M., Dal Cin, P., DeWever, I., Fletcher, C.D., Mandahl, N., Combined morphologic and karyotypic study of 28 myxoid liposarcomas. Implications for a revised morphologic typing (1996) Am J Surg Pathol, 20, pp. 1047-1055. , a report from the CHAMP Group
dc.descriptionThelin-Jarnum, S., Lassen, C., Panagopoulos, I., Mandahl, N., Aman, P., Identification of genes differentially expressed in TLS-CHOP carrying myxoid liposarcomas (1999) Int J Cancer, 83, pp. 30-33
dc.descriptionDei Tos, A.P., Doglioni, C., Piccinin, S., Maestro, R., Mentzel, T., Barbareschi, M., Molecular abnormalities of the p53 pathway in dedifferentiated liposarcomas (1997) J Pathol, 181, pp. 8-13
dc.descriptionHisaoka, M., Tsuji, S., Morimitsu, Y., Hashimoto, H., Shimajiri, S., Komiya, S., Detection of TLS/FUS-CHOP fusion transcripts in myxoid and round cell liposarcomas by nested reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues (1998) Diagn Mol Pathol, 7, pp. 96-101
dc.descriptionPilotti, S., Della Torre, G., Lavarino, C., Sozzi, G., Minoletti, F., Vergani, B., Molecular abnormalities in liposarcoma: Role of MDM2 and CDK4-containing amplicons at 12q13-22 (1998) J Pathol, 185, pp. 188-190
dc.descriptionLeach, F.S., Tokino, T., Meltzer, P., Burrell, M., Oliner, J.D., Smith, S., p53 mutation and MDM2 amplification in human soft tissues sarcomas (1993) Cancer Res, 53, pp. 2231-2234
dc.descriptionNakayama, T., Toguchida, J., Wadayama, B., Kanoe, H., Kotoura, Y., Sasaki, M.S., MDM2 gene amplification in bone and soft-tissue tumors: Association with tumor progression in differentiated adipose-tissue tumors (1995) Int J Cancer, 64, pp. 342-346
dc.descriptionNilbert, M., Rydholm, A., Mitelman, F., Meltzer, P.S., Mandahl, N., Characterization of the 12q13-15 amplicon in soft tissue tumors (1995) Cancer Genet Cytogenet, 83, pp. 32-36
dc.descriptionKanoe, H., Nakayama, T., Murakami, H., Hosaka, T., Yamamoto, H., Nakashima, Y., Amplification of the CDK4 gene in sarcomas: Tumor specificity and relationship with the RB gene mutation (1998) Anticancer Res, 18, pp. 2317-2321
dc.descriptionJankowski, S.A., Mitchell, D.S., Smith, S.H., Trent, J.M., Meltzer, P.S., SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins (1994) Oncogene, 9, pp. 1205-1211
dc.descriptionJankowski, S.A., De Jong, P., Meltzer, P.S., Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas (1995) Genomics, 25, pp. 501-506
dc.descriptionPilotti, S., Lavarino, C., Mezzelani, A., Della Torre, C., Minoletti, F., Sozzi, G., Limited role of TP53 and TP53-related genes in myxoid liposarcoma (1998) Tumori, 84, pp. 571-577
dc.descriptionDei Tos, A.P., Piccinin, S., Doglioni, C., Vukosavljevic, T., Mentzel, T., Boiocchi, M., Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma (1997) Am J Pathol, 151, pp. 1531-1539
dc.languageen
dc.publisher
dc.relationOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
dc.rightsfechado
dc.sourceScopus
dc.titleMdm2+/cdk4+/p53+ Oral Liposarcoma: Case Report And Review Of The Literature
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución