Nongenotoxic Effects And A Reduction Of The Dxr-induced Genotoxic Effects Of Helianthus Annuus Linné (sunflower) Seeds Revealed By Micronucleus Assays In Mouse Bone Marrow

dc.creatorBoriollo M.F.G.
dc.creatorSouza L.S.
dc.creatorResende M.R.
dc.creatorda Silva T.A.
dc.creatorOliveira N.D.M.S.
dc.creatorResck M.C.C.
dc.creatorDias C.T.D.S.
dc.creatorFiorini J.E.
dc.date2014
dc.date2015-06-25T17:52:30Z
dc.date2015-11-26T14:16:58Z
dc.date2015-06-25T17:52:30Z
dc.date2015-11-26T14:16:58Z
dc.date.accessioned2018-03-28T21:18:00Z
dc.date.available2018-03-28T21:18:00Z
dc.identifier
dc.identifierBmc Complementary And Alternative Medicine. Biomed Central Ltd., v. 14, n. , p. - , 2014.
dc.identifier14726882
dc.identifier10.1186/1472-6882-14-121
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84899491893&partnerID=40&md5=0d01ad0c42f31e25863ff594e5d4f88e
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86282
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86282
dc.identifier2-s2.0-84899491893
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1243208
dc.descriptionBackground: This research evaluated the genotoxicity of oil and tincture of H. annuus L. seeds using the micronucleus assay in bone marrow of mice. The interaction between these preparations and the genotoxic effects of doxorubicin (DXR) was also analysed (antigenotoxicity test) .Methods: Experimental groups were evaluated at 24-48 h post treatment with N-Nitroso-N-ethylurea (positive control - NEU), DXR (chemotherapeutic), NaCl (negative control), a sunflower tincture (THALS) and two sources of sunflower oils (POHALS and FOHALS). Antigenotoxic assays were carried out using the sunflower tincture and oils separately and in combination with NUE or DXR. Results: For THALS, analysis of the MNPCEs showed no significant differences between treatment doses (250-2,000 mg.Kg-1) and NaCl. A significant reduction in MNPCE was observed when THALS (2,000 mg.Kg-1) was administered in combination with DXR (5 mg.Kg-1). For POHALS or FOHALS, analysis of the MNPCEs also showed no significant differences between treatment doses (250-2,000 mg.Kg-1) and NaCl. However, the combination DXR + POHALS (2,000 mg.Kg-1) or DXR + FOHALS (2,000 mg.Kg-1) not contributed to the MNPCEs reduction. Conclusions: This research suggests absence of genotoxicity of THALS, dose-, time- and sex-independent, and its combination with DXR can reduce the genotoxic effects of DXR. POHALS and FOHALS also showed absence of genotoxicity, but their association with DXR showed no antigenotoxic effects. © 2014 Boriollo et al.; licensee BioMed Central Ltd.
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dc.languageen
dc.publisherBioMed Central Ltd.
dc.relationBMC Complementary and Alternative Medicine
dc.rightsaberto
dc.sourceScopus
dc.titleNongenotoxic Effects And A Reduction Of The Dxr-induced Genotoxic Effects Of Helianthus Annuus Linné (sunflower) Seeds Revealed By Micronucleus Assays In Mouse Bone Marrow
dc.typeArtículos de revistas


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