Continuous Chromatographic Separation Of A Baclofen Precursor (n-boc-4-[p-chloro-phenyl]-2-pyrrolidone) In A Simulated Moving Bed Using A Polysaccharide Carbamate As Chiral Stationary Phase

dc.creatorde Veredas V.
dc.creatorCarpes M.J.S.
dc.creatorCorreia C.R.D.
dc.creatorSantana C.C.
dc.date2006
dc.date2015-06-30T18:02:17Z
dc.date2015-11-26T14:16:14Z
dc.date2015-06-30T18:02:17Z
dc.date2015-11-26T14:16:14Z
dc.date.accessioned2018-03-28T21:17:11Z
dc.date.available2018-03-28T21:17:11Z
dc.identifier
dc.identifierJournal Of Chromatography A. , v. 1119, n. 01/02/15, p. 156 - 162, 2006.
dc.identifier219673
dc.identifier10.1016/j.chroma.2006.01.003
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-33744831758&partnerID=40&md5=12e86922348679b9086e23aa7ba825ed
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/102775
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/102775
dc.identifier2-s2.0-33744831758
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1243003
dc.descriptionLiquid chromatography is known as one of the most flexible, efficient and cost-effective methods to resolve racemic mixture in order to attend the growing demand of the pharmaceutical industry for pure enantiomeric compounds. Cellulose tris(3,5-dimethylphenylcarbamate) is frequently used as a stationary phase for enantiomeric separations because of its attractive properties, including high enantioselectivity, high loading capacity and good mechanical stability. In this study, we investigated the usefulness of cellulose tris(3,5-dimethylphenylcarbamate) as the stationary phase and of ethanol and hexane mixtures as the mobile phases for the chromatographic separation of potential pharmaceutical intermediates. Using adsorption equilibrium data, we determined the optimal operational conditions for the separation of the N-Boc-4-[p-chloro-phenyl]-2-pyrrolidone enantiomers - a baclofen precursor - in a semi-preparative scale simulated moving bed unit. This unit was used to obtain high purity enantiomers on a scale of 1 g/day. The outlet streams were analyzed by an on-line system that consisted of a UV-vis spectrophotometric unit, a polarimeter, and HPLC. Enantiomeric purities of up to 97% were obtained for the raffinate stream and up to 90% for the extract stream. © 2006 Elsevier B.V. All rights reserved.
dc.description1119
dc.description01/02/15
dc.description156
dc.description162
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dc.languageen
dc.publisher
dc.relationJournal of Chromatography A
dc.rightsfechado
dc.sourceScopus
dc.titleContinuous Chromatographic Separation Of A Baclofen Precursor (n-boc-4-[p-chloro-phenyl]-2-pyrrolidone) In A Simulated Moving Bed Using A Polysaccharide Carbamate As Chiral Stationary Phase
dc.typeArtículos de revistas


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