Mass Spectrometric Quantitation Of Chiral Drugs By The Kinetic Method

dc.creatorTao W.A.
dc.creatorGozzo F.C.
dc.creatorCooks R.G.
dc.date2001
dc.date2015-06-26T14:42:22Z
dc.date2015-11-26T14:15:37Z
dc.date2015-06-26T14:42:22Z
dc.date2015-11-26T14:15:37Z
dc.date.accessioned2018-03-28T21:16:32Z
dc.date.available2018-03-28T21:16:32Z
dc.identifier
dc.identifierAnalytical Chemistry. , v. 73, n. 8, p. 1692 - 1698, 2001.
dc.identifier32700
dc.identifier10.1021/ac001150v
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0035870199&partnerID=40&md5=5db39c4b142ebc6fcdd17034975c1ba3
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/94835
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/94835
dc.identifier2-s2.0-0035870199
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1242844
dc.descriptionA novel mass spectrometric method for rapid, accurate (2-4% ee) quantitation of chiral drugs is described. Copper(II)-bound complexes of seven model drugs (atenolol, DOPA, ephedrine, pseudoephedrine, isoproterenol, norepinephrine, propranolol) with chiral reference compounds (L-amino acids) are generated by electrospray ionization mass spectrometry. The trimeric complex ions (three chiral ligands-one of the analyte and two of the reference compound) are collisionally activated, and they undergo dissociation by competitive loss of either the neutral reference or the neutral drug molecule. The ratio of the two competitive dissociation rates, viz. the product ion branching ratio, is related via the kinetic method to the enantiomeric composition of the drug mixture. A two-point calibration curve, derived from the kinetic method, allows rapid quantitation of enantiomeric excess of drug mixtures. The chiral sensitivity of the method is such as to allow determination of mixtures with a few percent enantiomeric contamination.
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dc.description8
dc.description1692
dc.description1698
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dc.languageen
dc.publisher
dc.relationAnalytical Chemistry
dc.rightsfechado
dc.sourceScopus
dc.titleMass Spectrometric Quantitation Of Chiral Drugs By The Kinetic Method
dc.typeArtículos de revistas


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