dc.creatorLongui C.A.
dc.creatorLemos-Marini S.H.V.
dc.creatorFigueiredo B.
dc.creatorMendonca B.B.
dc.creatorCastro M.
dc.creatorLiberatore Jr. R.
dc.creatorWatanabe C.
dc.creatorLancellotti C.L.P.
dc.creatorRocha M.N.
dc.creatorMelo M.B.
dc.creatorMonte O.
dc.creatorCalliari L.E.P.
dc.creatorGuerra Jr. G.
dc.creatorBaptista M.T.M.
dc.creatorSbragia-Neto L.
dc.creatorLatronico A.C.
dc.creatorMoreira A.
dc.creatorTardelli A.M.D.
dc.creatorNigri A.
dc.creatorTaymans S.E.
dc.creatorStratakis C.A.
dc.date2004
dc.date2015-06-26T14:25:25Z
dc.date2015-11-26T14:15:04Z
dc.date2015-06-26T14:25:25Z
dc.date2015-11-26T14:15:04Z
dc.date.accessioned2018-03-28T21:15:56Z
dc.date.available2018-03-28T21:15:56Z
dc.identifier
dc.identifierJournal Of Medical Genetics. , v. 41, n. 5, p. 354 - 359, 2004.
dc.identifier222593
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-2342488713&partnerID=40&md5=57ad7966f2506a36b37d5af3d833b55b
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/94753
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/94753
dc.identifier2-s2.0-2342488713
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1242691
dc.descriptionThe R337H TP53 mutation is a low-penetrance molecular defect that predisposes to adrenocortical tumour (ACT) formation in Brazilian and possibly other populations. Additional genetic defects may be responsible for the variable expression of ACTs m these cases. The inhibin α-subunit gene (INHA) on 2q33-qter has been implicated in mouse adrenocortical tumourigenesis. We studied 46 pediatric patients with ACTs from Brazil for INHA genetic alterations; 39 of these patients were heterozygous carriers of the R337H TP53 mutation. We first mapped the INHA gene by radiation hybrid analysis and determined 10 linked microsatellite markers in an area flanked by D2S1371 and D2S206 on 2q33-qter. These markers were then used for loss of heterozygozity (LOH) studies in nine paired germline and tumour DNA samples. Mapping placed the INHA gene in close proximity to D2S2848 (SHGC11864) with a log of odds (LOD) score of 5.84. LOH for at least one marker in the region was identified in 8/9 tumours (89%). Six patients were heterozygous for three INHA mutations: one in exon 1, 127C>G, and two in exon 2,3998G>A and 4088G>A, all leading to amino acid substitutions (P43A, G227R, and A257T, respectively). A257T is located in a conserved INHA region, highly homologous to transforming growth factor-β; both G227R and A257T change polarity, and, in addition, G227R changes the pH. We conclude that these sequence alterations and the detected 2q allelic changes suggest that INHA may be one of the contributing factors needed for ACT formation in pediatric patient carriers of the R337H TP53 mutation.
dc.description41
dc.description5
dc.description354
dc.description359
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dc.languageen
dc.publisher
dc.relationJournal of Medical Genetics
dc.rightsfechado
dc.sourceScopus
dc.titleInhibin α-subunit (inha) Gene And Locus Changes In Paediatric Adrenocortical Tumours From Tp53 R337h Mutation Heterozygote Carriers
dc.typeArtículos de revistas


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