Reduction, Refinement And Replacement Of Animal Use In Toxicity Testing: An Overview [redução, Refinamento E Substituição Do Uso De Animais Em Estudos Toxicológicos: Uma Abordagem Atual]

dc.creatorCazarin K.C.C.
dc.creatorCorrea C.L.
dc.creatorDuque Zambrone F.A.
dc.date2004
dc.date2015-06-26T14:24:41Z
dc.date2015-11-26T14:14:04Z
dc.date2015-06-26T14:24:41Z
dc.date2015-11-26T14:14:04Z
dc.date.accessioned2018-03-28T21:14:53Z
dc.date.available2018-03-28T21:14:53Z
dc.identifier
dc.identifierRevista Brasileira De Ciencias Farmaceuticas/brazilian Journal Of Pharmaceutical Sciences. , v. 40, n. 3, p. 289 - 299, 2004.
dc.identifier15169332
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-11144313563&partnerID=40&md5=4eb0da65717246bff5251339239dc6b1
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/94548
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/94548
dc.identifier2-s2.0-11144313563
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1242433
dc.descriptionToxicity assessment is the process of predicting the adverse effects that may be caused to an organism by exposuring it to a given chemical and, for regulation purposes, the most used model in toxicity testing is the animal. However, in today's society the use of animals has become a subject of much public health due to the large number of animals used as well as the pain and distress caused, mainly related to acute toxicity testing. The concept of the "Three Rs" - reduction, refinement, and replacement of animal use - emerged as a mean of removing inhumanity from animal experimentation and aiming to lower the number of animals used, in order to decrease the incidence or severity of inhumane procedures and to find alternative procedures to replace in vivo testing. Many alternative toxicological tests have already been implemented, even knowing that this process is very complex and need to be extensively validated and accepted by regulatory bodies. This paper presents an overview on several aspects of the "Three Rs", including historical evolution and implementation and validation of alternative methods, emphasizing its application on toxicity testing and in global harmonization.
dc.description40
dc.description3
dc.description289
dc.description299
dc.descriptionChronology (1997) Overview of the Issues, , http://www.hsus.org/ace/12443, [S.I
dc.descriptions.n.], [entre]
dc.descriptionBalls, M., Replacement of animal procedures: Alternatives in research, education and testing (1994) Lab. Animals, 28, pp. 193-211
dc.descriptionBalls, M., Van Zeller, A.-M., Halder, M., (2000) Progress in the Reduction, Refinement and Replacement of Animal Experimentation, , Amsterdam: Elsevier. 1795 p
dc.descriptionBarros, S.B.M., Davino, S.C., Avaliação da toxicidade (2003) Fundamentos de Toxicologia. 2.Ed., 5, pp. 57-68. , Oga, S. São Paulo: Atheneu. cap. 1
dc.descriptionBotham, C., Holmes, P., Levy, L.S., Harrison, P.T.C., (2001) Prospects for the Use of Alternative Test Methods, , http://www.le.ac.uk/ieh/pdf/HoLfmal.pdf, Leicester: MRC Institute for Environment and Health
dc.descriptionBotham, P.A., Acute systemic toxicity (2002) ILAR J., 43 (SUPPL.), pp. S27-S30
dc.descriptionCorrêa, C.L., Alonzo, H.G.A., Trevisan, R.M.S., Avaliação do risco (2003) Fundamentos de Toxicologia. 2. Ed., pp. 69-76. , Oga, S. São Paulo: Atheneu. cap. 1.6
dc.descriptionDipasquale, L.C., Hayes, A.W., Acute toxicity and eye irritancy (2001) Principles and Methods of Toxicology. 4.Ed., pp. 853-916. , Hayes, A. W. London: Taylor & Francis. cap. 18
dc.descriptionEcobichon, D.J., (1997) The Basis of Toxicity Testing. 2. Ed., , Boca Raton: CRC Press. 220 p
dc.descriptionThe SIS Databases Provide Factual Information on Alternative Methods to Animal Experiments at Any Stage of Development and Validation, , http://ecvam.jrc.cec.eu.int/index.htm, [S.1: s. n.], [200-?]
dc.descriptionBackground to the three Rs declaration of Bologna, as adopted by the 3 rd World Congress on Alternatives and Animal Use in the Life Sciences, Bologna, Italy, on 31 August 1999 (2000) Progress in the Reduction, Refinement and Replacement of Animal Experimentation, pp. 17-22. , Balls, M.
dc.descriptionVan Zeller, A.-M
dc.descriptionHalder, M., eda. Amsterdam: Elsevier
dc.descriptionFesting, M.F.W., Reduction of animal use: Experimental design and quality of experiments (1994) Lab. Animals, 28, pp. 212-221
dc.descriptionFlecknell, P.A., Refinement of animal use - Assessment and alleviation of pain and distress (1994) Lab. Animals, 28, pp. 222-231
dc.description(2003), http://www.hsus.org/ace/352, Washington: [s.n.](2001) Annual Progress Report, , http.//iccvam.niehs.nih.gov/about/annrpt/annrpt01.pdf, [S.1.]: National Institute of Health
dc.description(1999) Evaluation of the Validation Status of Toxicological Methods: General Guidelines for Submissions to ICCVAM, , http://iccvam.niehs.nih.gov/docs/guidelines/subguide.htm, [S.1.]: National Institute of Health, rev. out. NIH Publication No. 99-4496
dc.description(2003) The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), , http://iccvam.niehs.nih.gov, S.1.: s.n
dc.description(1997) Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the Ad Hoc Interagency Coordinating Committee on the Validation of Alternative Methods, , http://iccvam.niehs.nih.gov/docs/guidelines/validate.pdf, [S.1.]: National Institute of Health. Publication NIH No: 97-3981
dc.descriptionKoeter, H.B.W.M., (2003) Development, Implementation and Use of Alternative Test Methods in Regulatory Hazard Assessment in OECD Member Countries, , http.//europa.eu.int/comm/research/info/conferences/rrr/ppt/koeter.pdf, Environment, health and safety division, OECD. Formato PDF. 1 apresentação, Power Point
dc.descriptionKoeter, H.B., Test guideline development and animal welfare: Regulatory acceptance of in vitro studies (1993) Reprod. Toxicol., 7 (SUPPL. 1), pp. 117-123
dc.descriptionMatfield, M., (2003) Research Defence Society (RDS): Understanding Animal Research in Medicine, , http://www.rds-online.org.uk, London: [s.n.]
dc.descriptionMeyer, O., Testing and assessment strategies, including alternative and new approaches (2003) Toxicol. Letters, 140-141, pp. 21-30
dc.descriptionOlden, K., (2004), http://ntp-server.niehs.nih.gov/, S.1: s.n(2000) OECD Guideline for the Testing of Chemicals: Acute Oral Toxicity - Up-and-down Procedure, , http://www.oecd.org/home/, Paris: OECD. Guideline 425
dc.description(1987) OECD Guideline for the Testing of Chemicals: Acute Oral Toxicity, , http://www.oecd.org/home/, Paris: OECD. Guideline 401
dc.description(2001) Harmonized Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures, , http://www.oecd.org/ehs/class/HCL6.htm, Paris: OECD
dc.description(1996) OECD Guideline for the Testing of Chemicals: Acute Oral Toxicity - Acute Toxic Class Method, , http://www.oecd.org/home/, Paris: OECD. Guideline n. 423
dc.description(1992) OECD Guideline for the Testing of Chemicals: Acute Oral Toxicity - Fixed Dose Method, , http://www.oecd.org/home/, Paris: OECD. Guideline n. 420
dc.description(2002) OECD Guideline for the Testing of Chemicals: In Vitro 3T3 NRU Photoxicity Test, , http://www.oecd.org/home/, Paris: OECD. Guideline Draft TG 432
dc.description(2002) OECD Guideline for the Testing of Chemicals: In Vitro Skin Corrosion: Human Skin Model Test, , http://www.oecd.org/home/, Paris: OECD. Guideline Draft TG 431
dc.description(2002) OECD Guideline for the Testing of Chemicals: In Vitro Skin Corrosion: Transcutaneous Eletrical Resistance Test (TER), , http://www.oecd.org/home/, Paris: OECD. Guideline Draft TG 430
dc.descriptionRichmond, J., Refinement, reduction, and replacement of animal use for regulatory testing: Future improvements and implementation within the regulatory framework (2002) ILAR Journal, 43 (SUPPL.), pp. S63-S68
dc.descriptionRussel, W.M.S., Burch, R.L., (1992) The Principles of Humane Experimental Technique, , http://altweb.jhsph.edu/publications/humane_exp/het-toc.htm, London: Universities Federation for Animal Welfare (UFAW). ISBN: 0900767782. Special Edition
dc.descriptionSchechtman, L.M., Implementation of the 3Rs (Refinement, reduction, and replacement): Validation and regulatory acceptance considerations for alternative toxicological test methods (2002) ILAR Journal, 43 (SUPPL.), pp. S85-S94
dc.descriptionSchlede, E., Diener, W., Gerner, I., (1998) Humane Endpoints in Toxicity Testing, pp. 75-78. , www.lal.org.uk/pdffiles/schlede.pdf, HUMANE endpoints in animals experiments for biomedical research. London: Royal Society of Medicine Press, [entre]
dc.descriptionSpielmann, H., Animal use in the safety evaluation of chemicals: Harmonization and emerging needs (2002) ILAR Journal, 43 (SUPPL.), pp. S11-S17
dc.descriptionStephens, M.L., Goldberg, A.M., Rowan, A.N., The first forty years of the alternatives approach: Refining, reducing, and repalcing the use of laboratory animals (2001) The State of the Animals 2001, , http://files.hsus.org/web-files/PDF/MARK_State_of_Animals_Ch_08.pdf, Rowan, A. N. Washington: Humane Society Press. chapter 8
dc.descriptionStitzel, K.A., Tiered testing strategies - Acute local toxicity (2001) ILAR J., 43 (SUPPL.), pp. S21-S26
dc.descriptionStokes, W.S., Humane endpoint for laboratory animals used in regulatory testing (2002) ILAR J., 43 (SUPPL.), pp. S31-S38
dc.descriptionThree Rs declaration of Bologna (2000) Progress in the Reduction, Refinement and Replacement of Animal Expérimentation, p. 15. , Balls, M.
dc.descriptionVan Zeller, A.-M
dc.descriptionHalder, M., eds. Amsterdam: Elsevier
dc.descriptionWhite, W.J., The use of laboratory animals in toxicologic research (2001) Principles and Methods of Toxicology. 4.Ed., pp. 773-818. , Hayes, A. W. London: Taylor & Francis. cap. 16
dc.descriptionWorth, A.P., Balls, M., The principles of validation and the ECVAM validation process (2002) Altern. Lab. Anim., 2 (SUPPL.), pp. 15-21
dc.descriptionZurlo, J., Rudacille, D., Goldberg, A.M., (2002) Animal and Alternatives in Testing: History, Science, and Ethics, , http://caat.jhsph.edu/pubs/animal_alts/animal_alts.htm, Larchmont: The Johns Hopkins University
dc.languagept
dc.publisher
dc.relationRevista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences
dc.rightsfechado
dc.sourceScopus
dc.titleReduction, Refinement And Replacement Of Animal Use In Toxicity Testing: An Overview [redução, Refinamento E Substituição Do Uso De Animais Em Estudos Toxicológicos: Uma Abordagem Atual]
dc.typeArtículos de revistas


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