Gastro-resistant Controlled Release Of Otc Encapsulated In Alginate/chitosan Matrix Coated With Acryl-eze® Mp In Fluidized Bed

dc.creatorKleinubing S.A.
dc.creatorSeraphim D.C.
dc.creatorVieira M.G.A.
dc.creatorCanevesi R.L.S.
dc.creatorDa Silva E.A.
dc.creatorCesar C.L.
dc.creatorMei L.H.I.
dc.date2014
dc.date2015-06-25T17:52:07Z
dc.date2015-11-26T14:13:51Z
dc.date2015-06-25T17:52:07Z
dc.date2015-11-26T14:13:51Z
dc.date.accessioned2018-03-28T21:14:39Z
dc.date.available2018-03-28T21:14:39Z
dc.identifier
dc.identifierJournal Of Applied Polymer Science. John Wiley And Sons Inc., v. 131, n. 12, p. - , 2014.
dc.identifier218995
dc.identifier10.1002/app.40444
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-84896395971&partnerID=40&md5=162f3264d0041bf1749d01abe0fb6f0d
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/86219
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/86219
dc.identifier2-s2.0-84896395971
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1242375
dc.descriptionA gastro-resistant system of acryl-EZE® MP coated alginate/chitosan microparticles was developed to improve the controlled release of oxytetracycline (OTC). Microparticles were obtained by complex coacervation and, thereafter, were coated using fluidized polymer dispersion with acryl-EZE® MP solution. OTC distribution inside the microparticles was determined by multiphoton confocal microscopy, demonstrating the efficiency of encapsulation process. In vitro OTC release kinetic was performed in order to obtain the release profile in gastric and intestinal simulated fluids. A fast initial release, or burst effect, was observed with uncoated microparticles loaded with OTC in gastric conditions. When a 50% mass increase in acryl-EZE® MP coating was achieved, OTC release in acidic medium was greatly reduced, resulting in the expected gastro-resistant effect. Different mathematical models were applied to describe the drug diffusion across the polymer matrix. The Logistic model was the best tool to interpret the experimental data in most of the systems studied. © 2014 Wiley Periodicals, Inc.
dc.description131
dc.description12
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dc.languageen
dc.publisherJohn Wiley and Sons Inc.
dc.relationJournal of Applied Polymer Science
dc.rightsfechado
dc.sourceScopus
dc.titleGastro-resistant Controlled Release Of Otc Encapsulated In Alginate/chitosan Matrix Coated With Acryl-eze® Mp In Fluidized Bed
dc.typeArtículos de revistas


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