Analysis Of The Transforming Growth Factor-β1 Gene Promoter Polymorphisms In Early Osseointegrated Implant Failure

dc.creatorDos Santos M.C.L.G.
dc.creatorCampos M.I.G.
dc.creatorSouza A.P.
dc.creatorScarei-Caminaga R.M.
dc.creatorMazzonetto R.
dc.creatorLine S.R.P.
dc.date2004
dc.date2015-06-26T14:24:26Z
dc.date2015-11-26T14:13:39Z
dc.date2015-06-26T14:24:26Z
dc.date2015-11-26T14:13:39Z
dc.date.accessioned2018-03-28T21:14:26Z
dc.date.available2018-03-28T21:14:26Z
dc.identifier
dc.identifierImplant Dentistry. , v. 13, n. 3, p. 262 - 269, 2004.
dc.identifier10566163
dc.identifier10.1097/01.id.0000140463.10204.87
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-7944223871&partnerID=40&md5=29e7ad4294c2eedacf30df3f73d07fba
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/94457
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/94457
dc.identifier2-s2.0-7944223871
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1242343
dc.descriptionTransforming growth factor-β1 is a multifunctional cytokine involved in extracellular matrix deposition, reduction of inflammation, and promotion of wound healing. Single nucleotide polymorphisms in the promoter region of human transforming growth factor-β1 gene, C-509T and G-800A, have been shown to increase the transcriptional activity of this cytokine and have been associated with a variety of diseases. The objective of this study was to investigate the possible association between these single nucleotide polymorphisms and the early implant failure. A sample of 68 nonsmoking patients was divided into two groups: a test group comprising 28 patients with one or more early failed implants and a control group consisting of 40 individuals with one or more healthy implants. Genomic DNA from oral mucosa was amplified by polymerase chain reaction and analyzed by restriction fragment length polymorphism. The significance of the differences in observed frequencies of single nucleotide polymorphisms was assessed using the chi square test and Fisher's exact test. The cited single nucleotide polymorphisms in transforming growth factor-β1 were analyzed in combination as haplotype using the computer program ARLEQUIN. The authors did not observe significant differences in the allele and genotypes to both single nucleotide polymorphisms of transforming growth factor-β, gene (C-509T and G-800A) between control and early implant failure groups. The distribution of the haplotypes arranged as allele and genotypes were similar between control and test groups. These results indicate that C-509T and G-800A polymorphisms in the transforming growth factor-β1 gene are not associated separately or in haplotype combinations with early implant failure, suggesting that the presence of those single nucleotide polymorphisms alone do not constitute a genetic risk factor for early implant failure in the Brazilian population.
dc.description13
dc.description3
dc.description262
dc.description269
dc.descriptionMassagué, J., The transforming growth factor-β family (1990) Annu Rev Cell Biol, 6, pp. 597-641
dc.descriptionSyrris, P., Carter, N.D., Metcalfe, J.C., Transforming growth factor-beta1 gene polymorphisms and coronary artery disease (1998) Clin Sci (Lond), 95, pp. 659-667
dc.descriptionDerynck, R., Jarrett, J.A., Chen, E.Y., Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells (1985) Nature, 316, pp. 701-705
dc.descriptionPulleyn, L.J., Newton, R., Adcock, I.M., TGFbeta1 allele association with asthma severity (2001) Hum Genet, 109, pp. 623-627
dc.descriptionLácha, J., Hubacek, J.A., Potmesil, P., TGF-beta I gene polymorphism in heart transplant recipients-effect on renal function (2001) Ann Transplant, 6, pp. 39-43
dc.descriptionWang, D., Kanuma, T., Mizunuma, H., Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer (2000) Cancer Res, 60, pp. 4507-4512
dc.descriptionPolyak, K., Negative regulation of cell growth by TGF-beta1 (1996) Biochim Biophys Acta, 1242, pp. 185-199
dc.descriptionDe Martin, R., Haendler, B., Hoferwarbinek, R., Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family (1987) EMBO J, 6, pp. 3673-3677
dc.descriptionWrann, M., Bodmer, S., De Martin, R., T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta (1987) EMBO J, 6, pp. 1633-1636
dc.descriptionIgnotz, R.A., Massague, J., Cell adhesion protein receptors as targets for transforming growth factor-beta action (1987) Cell, 51, pp. 189-197
dc.descriptionMustoe, T.A., Pierce, G.F., Thomason, A., Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta (1987) Science, 237, pp. 1333-1336
dc.descriptionFujii, D., Brissenden, J.E., Derynck, R., Transforming growth factor beta gene maps to human chromosome 19 long arm and to mouse chromosome 7 (1986) Somat Cell Mol Genet, 12, pp. 281-288
dc.descriptionCambien, F., Ricard, S., Troesch, A., Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure (1996) Hypertension, 28, pp. 881-887
dc.descriptionThompson, M.W., Mclnnes, R.R., Willard, H.F., (1991) Genetics in Medicine. 5th Ed., , Philadelphia: Thompson & Thompson
dc.descriptionHobbs, K., Negri, J., Klinnert, M., Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma (1998) Am J Respir Crit Care Med, 158, pp. 1958-1962
dc.descriptionGrainger, D.J., Metcalfe, J.C., Transforming growth factor-beta and cardiovascular protection (1997) The Endothelium in Clinical Practice. Source and Target of Novel Therapies. 1st Ed., pp. 203-243. , Rubanyi GM, Dzau, VJ, eds. New York: Marcel Dekker Inc
dc.descriptionGrainger, D.J., Heathcote, K., Chiano, M., Genetic control of the circulating concentration of transforming growth factor type beta1 (1999) Hum Mol Genet, 8, pp. 93-97
dc.descriptionColletta, A.A., Wakefield, L.M., Howell, F.V., The growth inhibition of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor beta (1991) J Clin Invest, 87, pp. 277-283
dc.descriptionHarrison, N.K., Argent, A.C., McAnulty, R.J., Collagen synthesis and degradation by systemic sclerosis lung fibroblasts. Responses to transforming growth factor-beta (1991) Chest, 99, pp. 71S-72S
dc.descriptionBroekelmann, T.J., Limper, A.H., Colby, T.V., Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis (1999) Proc Natl Acad Sci USA, 88, pp. 6642-6646
dc.descriptionFinkelman, R.D., Bell, N.H., Strong, D.D., Ovariectomy selectively reduces the concentration of transforming growth factor beta in rat bone: Implications for estrogen deficiency-associated bone loss (1992) Proc Natl Acad Sci USA, 89, pp. 12190-12193
dc.descriptionGrainger, D.J., Kemp, P.R., Liu, A.C., Activation of transforming growth factor-beta is inhibited in transgenic apolipoprotein(a) mice (1994) Nature, 370, pp. 460-462
dc.descriptionSouza, A.P., Trevilatto, P.C., Scarel-Caminaga, R.M., Analysis of TGF-beta1 promoter polymorphism (C-509T) in patients with chronic periodontitis (2003) J Clin Periodontol, 30, pp. 519-523
dc.descriptionTrevilatto, P.C., Line, S.R., Use of buccal epithelial cells for PCR amplification of large DNA fragments (2000) J Forensic Odontostomatol, 18, pp. 6-9
dc.descriptionSanguinetti, C.J., Dias Neto, E., Rapid silver staining and recovery of PCR products separated on polyacrylamide gels (1994) Biotechniques, 17, pp. 914-921
dc.descriptionSham, P.C., Curtis, D., Monte Carlo tests for associations between disease and alleles at highly polymorphic loci (1995) Ann Hum Genet, 59, pp. 97-105
dc.descriptionEsposito, M., Hirsch, J.M., Lekholm, U., Biological factors contributing to failures of osseointegrated oral implants. (I). Success criteria and epidemiology (1998) Eur J Oral Sci, 106, pp. 527-551
dc.descriptionSantos, M.C.L.G., Campos, M.I.G., Line, S.R.P., Early dental implant failure: A review of the literature (2002) Braz J Oral Sci, 1, pp. 103-111
dc.descriptionAdell, R., Lekholm, U., Rockler, B., Marginal tissue reactions at osseointegrated titanium fixtures (I). A 3-year longitudinal prospective study (1986) Int J Oral Maxillofac Surg, 15, pp. 39-52
dc.descriptionLekholm, U., Adell, R., Lindhe, J., Marginal tissue reactions at osseointegrated titanium fixtures. (II) A cross-sectional retrospective study (1986) Int J Oral Maxillofac Surg, 15, pp. 53-61
dc.descriptionSeymour, G.J., Gemmell, E., Lenz, L.J., Immunohistologic analysis of the inflammatory infiltrates associated with osseointegrated implants (1989) Int J Oral Maxillofac Implants, 4, pp. 191-198
dc.descriptionSalvi, G.E., Brown, C.E., Fujihashi, K., Inflammatory mediators of the terminal dentition in adult and early onset periodontitis (1998) J Periodontal Res, 33, pp. 212-225
dc.descriptionDongari-Bagtzoglou, A.I., Ebersole, J.L., Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitis (1998) J Periodontol, 69, pp. 899-910
dc.descriptionHeath, J.K., Atkinson, S.J., Hembry, R.M., Bacterial antigens induce collagenase and prostaglandin E2 synthesis in human gingival fibroblasts through a primary effect on circulating mononuclear cells (1987) Infect Immun, 55, pp. 2148-2154
dc.descriptionKao, R.T., Curtis, D.A., Richards, D.W., Increased interleukin-1beta in the crevicular fluid of diseased implants. 1997 (1997) Int J Oral Maxillofac Implants, 10, pp. 696-701
dc.descriptionSalcetti, J.M., Moriarty, J.D., Cooper, L.F., The clinical, microbial, and host response characteristics of the failing implant (1997) Int J Oral Maxillofac Implants, 12, pp. 32-42
dc.descriptionAdamo, C.T., Mailhot, J.M., Smith, A.K., Connexin-43 expression in oral-derived human osteoblasts after transforming growth factor-beta and prostaglandin E2 exposure (2001) J Oral Implantol, 27, pp. 25-31
dc.descriptionPanagakos, F.S., Aboyoussef, H., Dondero, R., Detection and measurement of inflammatory cytokines in implant crevicular fluid: A pilot study (1996) Int J Oral Maxillofac Implants, 11, pp. 794-799
dc.descriptionAboyoussef, H., Carter, C., Jandinski, J.J., Detection of prostaglandin E2 and matrix metalloproteinases in implant crevicular fluid (1998) Int J Oral Maxillofac Implants, 13, pp. 689-696
dc.descriptionGreensteing, G., Hart, T.C., A critical assessment of interleukin-1 (IL-1) genotype when used in a genetic susceptibility test for severe choronic periodontitis (2002) J Periodontol, 73, pp. 231-247
dc.descriptionHolla, L.I., Fassmann, A., Benes, P., 5 polymorphisms in the transforming growth factor-beta 1 gene (TGF-beta 1) in adult periodontitis (2002) J Clin Periodontol, 29, pp. 336-341
dc.descriptionLuedecking, E.K., DeKosky, S.T., Mehdi, H., Analysis of genetic polymorphisms in the transforming growth factor-beta 1 gene and the risk of Alzheimer's disease (2000) Hum Genet, 106, pp. 565-569
dc.descriptionYokota, M., Ichihara, S., Lin, T.L., Association of a T29→C polymorphism of the transforming growth factor-beta1 gene with genetic susceptibility to myocardial infarction in Japanese (2000) Circulation, 101, pp. 2783-2787
dc.descriptionArkwright, P.D., Laurie, S., Super, M., TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis (2000) Thorax, 55, pp. 459-462
dc.descriptionPulleyn, L.J., Newton, R., Adcock, I.M., TGF-beta1 allele association with asthma severity (2001) Hum Genet, 109, pp. 623-627
dc.descriptionMc Donnell, G.V., Kirk, C.W., Hawkins, S.A., Lack of association of transforming growth factor (TGF)-beta 1 and beta 2 gene polymorphisms with multiple sclerosis (MS) in Northern Ireland (1999) Mult Scler, 5, pp. 105-109
dc.descriptionFrossard, P.M., Pravica, V., Perrey, C., Lack of association between human TGF-beta1 gene variants and primary hypertension (2000) Am J Hypertens, 13, pp. 944-945
dc.descriptionBuckova, D., Izakovicova Holla, L., Benes, P., TGF-beta1 gene polymorphisms (2001) Allergy, 56, pp. 1236-1237
dc.descriptionBijlsma, F.J., Van Der Horst, A.A., Tilanus, M.G., No association between transforming growth factor beta gene polymorphism and acute allograft rejection after cardiac transplantation (2002) Transpl Immunol, 10, pp. 43-47
dc.descriptionAlansari, A., Hajeer, A., Teh, L.S., Transforming growth factor-12 polymorphism and systemic lupus erythematosus (2002) J Rheumatol, 29, pp. 1189-1191
dc.descriptionGewaltig, J., Mangasser-Stephan, K., Gartung, C., Association of polymorphisms of the transforming growth factor-betal gene with the rate of progression of HCV-induced liverfibrosis (2002) Clin Chim Acta, 316, pp. 83-94
dc.descriptionWilson Jr., T.G., Nunn, M., The relationship between the interleukin-1 periodontal genotype and implant loss. Initial data (1999) J Periodontol, 70, pp. 724-729
dc.descriptionGreensteing, G., Hart, T.C., A critical assessment of interleukin-1 (IL-1) genotype when used in a genetic susceptibility test for severe choronic periodontitis (2002) J Periodontol, 73, pp. 231-247
dc.descriptionRogers, M.A., Figliomeni, L., Baluchova, K., Do interleukin-1 polymorphisms predict the development of periodontitis or the success of dental implants? (2002) J Periodont Res, 37, pp. 37-41
dc.descriptionFeloutzis, A., Lang, N.P., Tonetti, M.S., IL-1 gene polymorphism and smoking as risk factors for peri-implant bone loss in a well-maintained population (2003) Clin Oral Implant Res, 14, pp. 10-17
dc.descriptionSantos, M.C.L.G., Campos, M.I.G., Souza, A.P., Analysis of MMP-1 and MMP-9 promoter polymorphisms in early osseointegrated implant failure (2004) Int J Oral Maxillofac Implants, 19, pp. 38-43
dc.descriptionSouza, A.P., Trevilatto, P.C., Scarel-Caminaga, R.M., MMP-1 promoter polymorphism: Association with chronic periodontitis severity in a Brazilian population (2003) J Clin Periodontol, 30, pp. 154-158
dc.descriptionMusso, T., Espinoza-Delgado, I., Pulkki, K., Transforming growth factor beta downregulates interleukin-1 (IL-1)-induced IL-6 production by human monocytes (1990) Blood, 76, pp. 2466-2469
dc.descriptionSteinsvoll, S., Halstensen, T.S., Schenck, K., Extensive expression of TGF-beta1 in chronically-inflamed periodontal tissue (1999) J Clin Periodontol, 26, pp. 366-373
dc.descriptionPage, R.C., Host response tests for diagnosing periodontal diseases (1992) J Periodontol, 63, pp. 356-366
dc.descriptionBirkedal-Hansen, H., Role of matrix metalloproteinases in human periodontal diseases (1993) J Periodontol, 64, pp. 4744-4784
dc.descriptionStanczuk, G.A., Tswana, S.A., Bergstrom, S., Polymorphism in codons 10 and 25 of the transforming growth factorbeta 1 gene in patients with invasive squamous cell carcinoma of the uterine cervix (2002) Eur J Immunogenet, 29, pp. 417-421
dc.languageen
dc.publisher
dc.relationImplant Dentistry
dc.rightsfechado
dc.sourceScopus
dc.titleAnalysis Of The Transforming Growth Factor-β1 Gene Promoter Polymorphisms In Early Osseointegrated Implant Failure
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución