Dapsone Hypersensitivity Syndrome In An Adolescent During Treatment Of Leprosy

dc.creatorBucaretchi F.
dc.creatorVicente D.C.
dc.creatorPereira R.M.
dc.creatorTresoldi A.T.
dc.date2004
dc.date2015-06-26T14:23:09Z
dc.date2015-11-26T14:11:32Z
dc.date2015-06-26T14:23:09Z
dc.date2015-11-26T14:11:32Z
dc.date.accessioned2018-03-28T21:12:04Z
dc.date.available2018-03-28T21:12:04Z
dc.identifier
dc.identifierRevista Do Instituto De Medicina Tropical De Sao Paulo. , v. 46, n. 6, p. 331 - 334, 2004.
dc.identifier364665
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-11144234239&partnerID=40&md5=c5f282d4928a27bef588c1d2b3a9ef57
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/94092
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/94092
dc.identifier2-s2.0-11144234239
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1241754
dc.descriptionA 12 y old girl was admitted 24 days after start a WHO multidrug therapy scheme for multibacillary leprosy (dapsone, clofazimine and rifampicin) with intense jaundice, generalized lymphadenopathy, hepatoesplenomegaly, oral erosions, conjunctivitis, morbiliform rash and edema of face, ankles and hands. The main laboratory data on admission included: hemoglobin, 8.4 g/dL; WBC, 15,710 cells/mm3; platelet count, 100,000 cells/mm3; INR = 1.49; increased serum levels of aspartate and alanine aminotransferases, gamma-glutamyl transpeptidase, alkaline phosphatase, direct and indirect bilirubin. Following, the clinical conditions had deteriorated, developing exfoliative dermatitis, shock, generalized edema, acute renal and hepatic failure, pancytopenia, intestinal bleeding, pneumonia, urinary tract infection and bacteremia, needing adrenergic drugs, replacement of fluids and blood product components, and antibiotics. Ten days after admission she started to improve, and was discharged to home at day 39th, after start new supervised treatment for leprosy with clofazimine and rifampicin, without adverse effects. This presentation fulfils the criteria for the diagnosis of dapsone hypersensitivity syndrome (fever, generalized lymphadenopathy, exfoliative rash, anemia and liver involvement with mixed hepatocellular and cholestatic features). Physicians, mainly in geographical areas with high prevalence rates of leprosy, should be aware to this severe, and probably not so rare, hypersensitivity reaction to dapsone.
dc.description46
dc.description6
dc.description331
dc.description334
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dc.languageen
dc.publisher
dc.relationRevista do Instituto de Medicina Tropical de Sao Paulo
dc.rightsaberto
dc.sourceScopus
dc.titleDapsone Hypersensitivity Syndrome In An Adolescent During Treatment Of Leprosy
dc.typeArtículos de revistas


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