Artículos de revistas
Human Eosinophil Chemotaxis And Selective In Vivo Recruitment By Sphingosine 1-phosphate
Registro en:
Proceedings Of The National Academy Of Sciences Of The United States Of America. , v. 101, n. 30, p. 11170 - 11175, 2004.
278424
10.1073/pnas.0401439101
2-s2.0-3342953519
Autor
Roviezzo F.
Del Galdo F.
Abbate G.
Bucci M.
D'Agostino B.
Antunes E.
De Dominicis G.
Parente L.
Rossi F.
Cirino G.
De Palma R.
Institución
Resumen
Sphingosine 1-phosphate (S1P) is a sphingolipid mediator that is involved in diverse biological functions. Local administration of S1P causes inflammation coupled to a large eosinophil (EO) recruitment in the rat-paw tissue. The inflammatory response is accompanied by an increase in S1P receptors, namely S1P1, S1P2, S1P3, and by an enhanced expression of CCR3, which is the main chemokine receptor known to be involved in EO function. Human EOs constitutively express S1P1 and, at a lower extent, S1P2, S1P3 receptors. S1P in vitro causes cultured human EO migration and an increase in S1P receptor mRNA copies and strongly up-regulates CCR3 and RANTES (regulated on activation, normal T cell-expressed and secreted) message levels; in particular CCR3 is up-regulated 18,000-fold by S1P. A blocking anti-CCR3 Ab inhibits S1P-induced chemotaxis, implying that S1P acts as specific recruiting signal for EOs not only through its own receptors but also through CCR3. 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