Infectious Complications In Patients Randomized To Receive Allogeneic Bone Marrow Or Peripheral Blood Transplantation

dc.creatorNucci M.
dc.creatorAndrade F.
dc.creatorVigorito A.
dc.creatorTrabasso P.
dc.creatorAranha J.F.
dc.creatorMaiolino A.
dc.creatorDe Souza C.A.
dc.date2003
dc.date2015-06-30T17:30:44Z
dc.date2015-11-26T14:09:58Z
dc.date2015-06-30T17:30:44Z
dc.date2015-11-26T14:09:58Z
dc.date.accessioned2018-03-28T21:10:35Z
dc.date.available2018-03-28T21:10:35Z
dc.identifier
dc.identifierTransplant Infectious Disease. , v. 5, n. 4, p. 167 - 173, 2003.
dc.identifier13982273
dc.identifier10.1111/j.1399-3062.2003.00033.x
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-2342471922&partnerID=40&md5=247992255ea07404d0f8266ae3e9e4bf
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/102381
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/102381
dc.identifier2-s2.0-2342471922
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1241385
dc.descriptionVery few data are available on the comparison of infectious complications in peripheral blood stem cell transplantation (PBSCT) and bone marrow transplant (BMT). The objective of this study was to evaluate the severity and frequency of infectious complications in patients randomized to receive PBSCT or BMT. We retrospectively reviewed the charts of all patients included in a randomized clinical trial comparing PBSCT (27 patients) and BMT (29 patients). We analyzed two periods: pre-engraftment and post-engraftment. In the pre-engraftment period, we compared the two groups with respect to the duration of neutropenia, antibiotic use and hospitalization, and documentation of infection. In the post-engraftment period, we analyzed the occurrence and severity of graft-versus-host disease (GVHD), duration of cyclosporine, corticosteroids, antibiotic, antiviral and antifungal prophylaxis, number of episodes of infection, and death rates. Patients receiving PBSCT had shorter duration of neutropenia, but there were no differences in the incidence of infections or duration of antibiotic therapy. Patients receiving PBSCT had a higher incidence of extensive chronic GVHD (65% vs. 39%, P = 0.08), longer duration of cyclosporine use (risk ratio [RR] 1.97), corticosteroids (RR 1.66), antibacterial (RR 2.60), antifungal (RR 2.50), anti-Pneumocystis carinii (RR 2.06) and anti-cytomegalovirus (RR 1.44) prophylaxis, and more infectious episodes (3.65 vs. 2.32 per 1000 days at risk, RR 1.57). There were no differences in death rates. Multivariate analysis identified the use of steroids as the most significant variable associated with infectious episodes. PBSCT was associated with more infections in the post-engraftment period. Copyright © Blackwell Munksgaard 2003.
dc.description5
dc.description4
dc.description167
dc.description173
dc.descriptionAzevedo, W.M., Aranha, F.J., Gouvea, J.V., Allogeneic transplantation with blood stem cells mobilized by rhG-CSF for hematological malignancies (1995) Bone Marrow Transplant, 16, pp. 647-653
dc.descriptionBensinger, W.I., Clift, R., Martin, P., Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: A retrospective comparison with marrow transplantation (1996) Blood, 88, pp. 2794-2800
dc.descriptionPavletic, Z.S., Bishop, M.R., Tarantolo, S.R., Hematopoietic recovery after allogeneic blood stem-cell transplantation compared with bone marrow transplantation in patients with hematologic malignancies (1997) J Clin Oncol, 15, pp. 1608-1616
dc.descriptionLemoli, R.M., Bandini, G., Leopardi, G., Allogeneic peripheral blood stem cell transplantation in patients with early-phase hematologic malignancy: A retrospective comparison of short-term outcome with bone marrow transplantation (1998) Haematologica, 83, pp. 48-55
dc.descriptionBacigalupo, A., Zikos, P., Van Lint, M.T., Allogeneic bone marrow or peripheral blood cell transplants in adults with hematologic malignancies: A single-center experience (1998) Exp Hematol, 26, pp. 409-414
dc.descriptionScott, M.A., Gandhi, M.K., Jestice, H.K., Mahendra, P., Bass, G., Marcus, R.E., A trend towards an increased incidence of chronic graft-versus-host disease following allogeneic peripheral blood progenitor cell transplantation: A case controlled study (1998) Bone Marrow Transplant, 22, pp. 273-276
dc.descriptionSolano, C., Martinez, C., Brunet, S., Chronic graft-versus-host disease after allogeneic peripheral blood progenitor cell or bone marrow transplantation from matched related donors. A case-control study (1998) Bone Marrow Transplant, 22, pp. 1129-1135. , Spanish Group of Allo-PBT
dc.descriptionUstun, C., Arslan, O., Beksac, M., A retrospective comparison of allogeneic peripheral blood stem cell and bone marrow transplantation results from a single center: A focus on the incidence of graft-vs.-host disease and relapse (1999) Biol Blood Marrow Transplant, 5, pp. 28-35
dc.descriptionRussell, J.A., Larratt, L., Brown, C., Allogeneic blood stem cell and bone marrow transplantation for acute myelogenous leukemia and myelodysplasia: Influence of stem cell source on outcome (1999) Bone Marrow Transplant, 24, pp. 1177-1183
dc.descriptionPowles, R., Mehta, J., Kulkarni, S., Allogeneic blood and bone-marrow stem-cell transplantation in haematological malignant diseases: A randomised trial (2000) Lancet, 355, pp. 1231-1237
dc.descriptionChamplin, R.E., Schmitz, N., Horowitz, M.M., Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation (2000) Blood, 95, pp. 3702-3709. , IBMTR Histocompatibility and Stem Cell Sources Working Committee and the European Group for Blood and Marrow Transplantation (EBMT)
dc.descriptionBlaise, D., Kuentz, M., Fortanter, C., Randomized trial of bone marrow versus lenograstim-primed blood cell allogeneic transplantation in patients with early-stage leukemia: A report from the Societe Francaise de Greffe de Moelle (2000) J Clin Oncol, 18, pp. 537-546
dc.descriptionBensinger, W.I., Martin, P.J., Stoker, B., Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers (2001) N Engl J Med, 344, pp. 175-181
dc.descriptionRemberger, M., Ringden, O., Blau, I.W., No difference in graft-versus-host disease, relapse, and survival comparing peripheral stem cells to bone marrow using unrelated donors (2001) Blood, 98, pp. 1739-1745
dc.descriptionVigorito, A.C., Marques Jr., J.F., Aranha, F.J., Oliveira, G.B., Miranda, E.C., De Souza, C.A., A randomized, prospective comparison of allogeneic bone marrow and peripheral blood progenitor cell transplantation in the treatment of hematologic malignancies: An update (2001) Haematologica, 86, pp. 665-666
dc.descriptionGuardiola, P., Runde, V., Bacigalupo, A., Retrospective comparison of bone marrow and granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells for allogeneic stem cell transplantation using HLA identical sibling donors in myelodysplastic syndromes (2002) Blood, 99, pp. 4370-4378
dc.descriptionSchmitz, N., Bacigalupo, A., Hasenclever, D., Allogeneic bone marrow transplantation vs. filgrastim-mobilised peripheral blood progenitor cell transplantation in patients with early leukaemia: First results of a randomised multicentre trial of the European Group for Blood and Marrow Transplantation (1998) Bone Marrow Transplant, 21, pp. 995-1003
dc.descriptionCouban, S., Simpson, D.R., Barnett, M.J., A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies (2002) Blood, 100, pp. 1525-1531
dc.descriptionMorton, J., Hutchins, C., Durrant, S., Granulocyte-colony-stimulating factor (G-CSF)-primed allogeneic bone marrow: Significantly less graft-versus-host disease and comparable engraftment to G-CSF-mobilized peripheral blood stem cells (2001) Blood, 98, pp. 3186-3191
dc.descriptionSchmitz, N., Beksac, M., Hasenclever, D., Transplantation of mobilized peripheral blood cells to HLA-identical siblings with standard-risk leukemia (2002) Blood, 100, pp. 761-767
dc.descriptionCutler, C., Giri, S., Jeyapalan, S., Paniagua, D., Viswanathan, A., Antin, J.H., Acute and chronic graft-versus-host disease after allogeneic peripheral-blood stem-cell and bone marrow transplantation: A meta-analysis (2001) J Clin Oncol, 19, pp. 3685-3691
dc.descriptionFlowers, M.E., Parker, P.M., Johnston, L.J., Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: Long-term follow-up of a randomized trial (2002) Blood, 100, pp. 415-419
dc.descriptionStorek, J., Dawson, M.A., Storer, B., Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation (2001) Blood, 97, pp. 3380-3389
dc.descriptionWlngard, J.R., Opportunistic infections after blood and marrow transplantation (1999) Transpl Infect Dis, 1, pp. 3-20
dc.descriptionVigorito, A.C., Azevedo, W.M., Marques, J.F., A randomised, prospective comparison of allogeneic bone marrow and peripheral blood progenitor cell transplantation in the treatment of haematological malignancies (1998) Bone Marrow Transplant, 22, pp. 1145-1151
dc.descriptionThe design, analysis, and reporting of clinical trials on the empirical antibiotic management of the neutropenic patient. Report of a consensus panel (1990) J Infect Dis, 161, pp. 397-401
dc.descriptionAscioglu, S., Rex, J.H., De Pauw, B., Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: An international consensus (2002) Clin Infect Dis, 34, pp. 7-14
dc.descriptionNucci, M., Spector, N., Bueno, A.P., Risk factors and attributable mortality associated with superinfections in neutropenic patients with cancer (1997) Clin Infect Dis, 24, pp. 575-579
dc.descriptionHeldal, D., Tjonnfjord, G., Brinch, L., A randomised study of allogeneic transplantation with stem cells from blood or bone marrow (2000) Bone Marrow Transplant, 25, pp. 1129-1136
dc.descriptionMahmoud, H., Fahmy, O., Kamel, A., Kamel, M., El Haddad, A., El Kadi, D., Peripheral blood vs. bone marrow as a source for allogeneic hematopoietic stem cell transplantation (1999) Bone Marrow Transplant, 24, pp. 355-358
dc.descriptionNivison-Smith, I., Bradstock, K.F., Szer, J., Allogeneic haemopoietic cell transplants in Australia, 1996 - A multi-centre retrospective comparison of the use of peripheral blood stem cells with bone marrow (2001) Bone Marrow Transplant, 28, pp. 21-27
dc.descriptionRingden, O., Remberger, M., Runde, V., Faster engraftment of neutrophils and platelets with peripheral blood stem cells from unrelated donors: A comparison with marrow transplantation (2000) Bone Marrow Transplant, 25 (SUPPL. 2), pp. S6-S8
dc.descriptionSerody, J.S., Sparks, S.D., Lin, Y., Comparison of granulocyte colony-stimulating factor (G-CSF) - Mobilized peripheral blood progenitor cells and G-CSF-stimulated bone marrow as a source of stem cells in HLA-matched sibling transplantation (2000) Biol Blood Marrow Transplant, 6, pp. 434-440
dc.descriptionHagglund, H., Ringden, O., Remberger, M., Faster neutrophil and platelet engraftment, but no differences in acute GVHD or survival, using peripheral blood stem cells from related and unrelated donors, compared to bone marrow (1998) Bone Marrow Transplant, 22, pp. 131-136
dc.descriptionLokhorst, H.M., Meuwissen, O.J., Bast, E.J., Dekker, A.W., VAD chemotherapy for refractory multiple myeloma (1989) Br J Haematol, 71, pp. 25-30
dc.descriptionAnaissie, E.J., Kontoyiannis, D.P., O'Brien, S., Infections in patients with chronic lymphocytic leukemia treated with fludarabine (1998) Ann Intern Med, 129, pp. 559-566
dc.descriptionWald, A., Leisenring, W., Van Burikj, A., Bowden, R.A., Epidemiology of Aspergillis infections in a large cohort of patients undergoing bone marrow transplantation (1997) J Infect Dis, 175, pp. 1459-1466
dc.descriptionRibaud, P., Chastang, C., Latge, J.P., Survival and prognostic factors of invasive aspergillosis after allogeneic bone marrow transplantation (1999) Clin Infect Dis, 28, pp. 322-330
dc.languageen
dc.publisher
dc.relationTransplant Infectious Disease
dc.rightsfechado
dc.sourceScopus
dc.titleInfectious Complications In Patients Randomized To Receive Allogeneic Bone Marrow Or Peripheral Blood Transplantation
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución