Acute Exposure To Imidazoline Derivatives In Children [exposição Aguda A Derivados Imidazolínicos Em Crianças]

dc.creatorBucaretchi F.
dc.creatorDragosavac S.
dc.creatorVieira R.J.
dc.date2003
dc.date2015-06-30T17:31:04Z
dc.date2015-11-26T14:09:57Z
dc.date2015-06-30T17:31:04Z
dc.date2015-11-26T14:09:57Z
dc.date.accessioned2018-03-28T21:10:35Z
dc.date.available2018-03-28T21:10:35Z
dc.identifier
dc.identifierJornal De Pediatria. , v. 79, n. 6, p. 519 - 524, 2003.
dc.identifier217557
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-1642419619&partnerID=40&md5=9dec5c7614200a93465a525810f226b6
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/102410
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/102410
dc.identifier2-s2.0-1642419619
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1241383
dc.descriptionObjectives: To study acute exposure to imidazoline derivatives in 72 children younger than 15 years of age, followed-up from January 1994 to December 1999. Methods: This is a retrospective study of 72 patients with age between 2 months and 13 years (median 2 years; 25-75% = 1 to 3 years old) exposed to naphazoline (N=48), fenoxazoline (N=18), oxymetazoline (N=5) and tetrahydrozoline (N=1), through oral (N=46), nasal (N=24) or unknown (N=2) routes. Results: Fifty-seven children developed clinical manifestations such as somnolence (N=34/57), sweating (N=20/57), pallor (N=17/ 57), hypothermia (N=16/57), bradycardia (N=13/57), cool extremities (N=9/57), restlessness (N=7/57), tachycardia (N=6/57), vomiting (N= 5/57), irregular respiratory pattern and apnea (N= 5/57), miosis/ mydriasis (N=4/57). Naphazoline was the active ingredient most frequently involved (N=47), followed by phenoxazoline (N=5) and oxymetazoline (N=4). The onset of clinical manifestations was rapid, beginning within 2 hours after exposure in 32/57 children, Only supportive measures were employed, with one child requiring mechanical ventilation after accidental naphazoline ingestion. In most of the children resolution of symptoms occurred within 24 hours (N= 39/57). No deaths were observed. Patients exposed to naphazoline (N=47/48) presented a higher frequency of clinical signs of poisoning in comparison with those exposed to phenoxazoline (N=5/18) (p < 0.001). There were no significant differences in the frequency of patients who presented clinical manifestations considering the route of exposure [oral (N=34/46), nasal (N=21/24); p=0.31]. Conclusions: Most children (especially those younger than 3 years) exposed to imidazoline derivatives (especially naphazoline) presented early signs of poisoning regardless of the exposure route (nasal or oral). The main signs observed were nervous system, cardiovascular and respiratory depression. Most children showed complete resolution of the symptoms within 24 hours.
dc.description79
dc.description6
dc.description519
dc.description524
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dc.languagept
dc.publisher
dc.relationJornal de Pediatria
dc.rightsaberto
dc.sourceScopus
dc.titleAcute Exposure To Imidazoline Derivatives In Children [exposição Aguda A Derivados Imidazolínicos Em Crianças]
dc.typeArtículos de revistas


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