Actas de congresos
Urinary Protein Excretion Profile: A Contribution For Subclinical Renal Damage Identification Among Environmental Heavy Metals Exposure In Southeast Brazil
Registro en:
Journal De Physique. Iv : Jp. , v. 107, n. I, p. 513 - 516, 2003.
11554339
2-s2.0-0038377389
Autor
Garlipp C.R.
Bottini P.V.
De Capitani E.M.
Pinho M.C.
Panzan A.D.N.
Sakuma A.M.A.
Paoliello M.B.
Institución
Resumen
In Southeast Brazil. Ribeira Valley region has been a major public health concern due to the environmental heavy metals contamination indexes of vegetation, rocks and aquifers, caused by local mining in the past. Human contamination by low levels of heavy metals doesn't cause acute intoxication but in chronic exposure, renal damage may occur with progressive tubulointerstitial changes evolving to glomerular lesion. In this study we investigated the relationship between the profile of urinary excreted proteins (glomerular or tubular origin) of arsenic and mercury and blood lead concentration in children and adults from highly exposed regions of the Ribeira Valley. The subjects were classified as GROUP 1 (G1; higher environmental risk, n=333) and GROUP 2 (G2; lower risk of contamination, n=104). In order to determine the urinary excretion of total protein, albumin (MA, glomerular marker) and alpha I microglobulin (A1M, tubular marker) and the blood lead concentrations, random urine and blood samples were obtained. Plasmatic lead levels were assessed by atomic absorption spectrometry with graphite furnace. Total protein concentration (PROT) was assessed on a biochemical analyzer (pyrogallol red method). MA and A1M were determined by nephelometric method. Group 1 showed a higher frequency of altered urinary excretion of PROT (G1=3.4%; G2=1.0%), MA (G1=9.0%; G2=5.1%) and A1M (G1=7.5%; G2=3.8%), without significant differences between both groups. Elevated arsenic levels were more prevalent among subjects from Group 1 (28.8%) and demonstrated a significant correlation with abnormal urinary excretion of albumin and alpha-1-microglobulin (p=0.019). Lead and mercury levels showed no difference among the groups and no correlation with MA and/or A1M. Our data suggests that abnormal urinary protein excretion is relatively frequent in this population independently of the plasmatic or urinary heavy metal levels. The early detection of possible renal damage become necessary for effective measures can be taken to prevent clinical nephropathies. 107 I 513 516 Eysink, G.G.J., Avaliação da qualidade ambiental do Rio Ribeira do Iguape- Considerações preliminares, relatório técnico da CETESB (1991), p. 54. , CETESB, São PauloPaoliello, M.M.B., De Capitani, E.M., Cunha, F.G., Matsuo, T., Carvalho, M.F., Sakuma, A., Figueiredo, B.R., Exposure of children to lead and cadmium from a mining area of Brazil (2002) Environmental Research, 88, pp. 120-128 Bennet, B.G., Exposure of man to environmental arsenic - an exposure commitment assessment (1981) Sci Total Environ, 20 (2), pp. 99-107 Hewitt, D.J., Millner, G.C., Nye, A.C., Simmons, H.F., Investigation of arsenic exposure from soil at a superfund site (1995) Environ. Research, 68, pp. 73-81 Goyer, R.A., Mechanisms of lead and cadmium nephrotoxicity (1989) Toxicol Lett., 46, pp. 153-162 Chia, K.S., Jeyaratnam, J., Lee, J., Tan, C., Ong, H.Y., Ong, C.N., Lee, E., Lead-induced nephropathy: Relationship between various biological exposure indices and early markers of nephrotoxicity (1995) Am J Ind Med, 27 (6), pp. 883-895 Kim, R., Rotnitsky, A., Sparrow, D., Weiss, S., Wager, C., Hu, H., A longitudinal study of low level lead exposure and impairment of renal function. The normative aging study (1996) JAMA, 275, pp. 1177-1181 Cardenas, A., Roels, H., Bernard, A.M., Markers of early renal changes induced by industrial pollutants. II. Application to workers exposed to lead (1993) Br J Ind Med, 50, pp. 28-36 Kusano, E., Suzuki, M., Asano, Y., Takagi, K., Tadashi, K., Human alfa-1-microglobulin and its relationship to renal function (1985) Nephron, 41, pp. 320-324 Pergande, M., Jung, K., Precht, S., Fels, L.M., Herbort, C., Stolte, H., Changed excretion of urinary proteins and enzymes by chronic exposure to lead (1994) Nephrol Dial Transplant, 9 (6), pp. 613-618 Preventing lead poisoning in young children: A statement by the centers for disease control (1991), Centers for Disease Control and Prevention- USDHHS- PHS, Washington, octoberPaschal, D.C., Trace metals in urine of United States residentes: Reference range concentrations (1998) Environ Research, 76, pp. 53-59 note