Effects Of Atorvastatin, Fluvastatin, Pravastatin, And Simvastatin On Endothelial Function, Lipid Peroxidation, And Aortic Atherosclerosis In Hypercholesterolemic Rabbits [efeitos Da Atorvastatina, Fluvastatina, Pravastatina E Simvastatina Sobre A Função Endotelial, A Peroxidação Lipídica E A Aterosclerose Aórtica Em Coelhos Hipercolesterolêmicos]

dc.creatorJorge P.A.R.
dc.creatorDe Almeida E.A.
dc.creatorOzaki M.R.
dc.creatorJorge M.
dc.creatorCarneiro A.
dc.date2005
dc.date2015-06-26T14:09:21Z
dc.date2015-11-26T14:09:22Z
dc.date2015-06-26T14:09:21Z
dc.date2015-11-26T14:09:22Z
dc.date.accessioned2018-03-28T21:09:55Z
dc.date.available2018-03-28T21:09:55Z
dc.identifier
dc.identifierArquivos Brasileiros De Cardiologia. , v. 84, n. 4, p. 314 - 319, 2005.
dc.identifier0066782X
dc.identifier
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-18844440664&partnerID=40&md5=d87ccdca05015f5c869fb86f0c2fdd41
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/93771
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/93771
dc.identifier2-s2.0-18844440664
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1241217
dc.descriptionObjective: To compare the effects of atorvastatin, fluvastatin, pravastatin, and simvastatin on endothelial function, aortic atherosclerosis, and the content of malondialdehyde (MDA) in native and oxidized LDL and in the arterial wall of hypercholesterolemic rabbits after adjusting the dosages of those statins to reduce total serum cholesterol levels to similar values. Methods: Male rabbits were divided into the following 6 groups of 10 animals (n=10): 1) GH (control) - hypercholesterolemic animals; 2) GA - atorvastatin; 3) GF - fluvastatin; 4) GP - pravastatin; 5) GS - simvastatin; and 6) GN - normal. The animals were fed a standard food preparation enriched with 0.5% cholesterol and 2% coconut oil for 45 days. Fifteen days after beginning the experiment, atorvastatin, fluvastatin, pravastatin and simvastatin were administered for 15 days through gavage, and the dosages were adjusted to obtain similar cholesterol values in each group. At the end of the experiment, a blood sample was withdrawn for determining total cholesterol and separating the lipoproteins, and a segment of the thoracic aorta was removed to be used for studying endothelial function and lipid peroxidation, and for measuring aortic atherosclerosis in histological sections. Results: The statins significantly reduced total serum cholesterol levels, LDL-cholesterol levels, and aortic atherosclerosis. The MDA content was also significantly reduced in native and oxidized LDL, as well as in the arterial wall. Endothelium-dependent relaxation was significantly greater in the treated group compared with that in the hypercholesterolemic group. Conclusion: The statins, at dosages adjusted, had a significant and similar effect in reducing lipid peroxidation in native and oxidized LDL-C and in arterial walls, in decreasing aortic atherosclerosis, and in reverting endothelial dysfunction.
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dc.languagept
dc.publisher
dc.relationArquivos Brasileiros de Cardiologia
dc.rightsaberto
dc.sourceScopus
dc.titleEffects Of Atorvastatin, Fluvastatin, Pravastatin, And Simvastatin On Endothelial Function, Lipid Peroxidation, And Aortic Atherosclerosis In Hypercholesterolemic Rabbits [efeitos Da Atorvastatina, Fluvastatina, Pravastatina E Simvastatina Sobre A Função Endotelial, A Peroxidação Lipídica E A Aterosclerose Aórtica Em Coelhos Hipercolesterolêmicos]
dc.typeArtículos de revistas


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