Extra-anatomical bypass is a technical option feasible when anatomical pathways are contraindicated or considered of high risk. In this paper we report a case of soft tissue sarcoma in the proximal third of the left lower extremity involving the femoral vessels. The patient was submitted to an extra-anatomical bypass from the external iliac artery to the popliteal artery with PTFE. She was then submitted to en bloc resection of the tumor, quadriceps muscle and femoral vessels. After a 24-month follow-up period the patient has patent PTFE graft and no evidence of local recurrence. Copyright © 2005 by Sociedade Brasileira de Angiologia e Cirurgia Vascular.42205208Eilber, F.R., Morton, K.L., Eckhardt, J., Grant, T., Weisenburger, T., Limb salvage for skeletal and soft tissue sarcoma: Multidisciplinary preoperative therapy (1983) Cancer, 53, pp. 2579-2584McKee, M.D., Liu, D.F., Brooks, J.J., Gibbs, J.F., Driscoll, D.L., Kraybill, W.G., The prognostic significance of margin width for extremity and trunk sarcoma (2004) J Surg Oncol, 85, pp. 68-76Ascer, E., Veith, F.J., Extra-anatomic bypasses (1996) Haimovici's Vascular Surgery, pp. 688-699. , Haimovici H, editor. Cambridge, MA: Blackwell Science, IncStojadinovic, A., Jaques, D.P., Leung, D.H., Healey, J.H., Brennan, M.F., Amputation for recurrent soft tissue sarcoma of the extremity: Indications and outcome (2001) Ann Surg Oncol, 8, pp. 509-518Davidovic, L.B., Kuzmanovic, I.B., Kostic, D.M., An obturator or "lateral" bypass in infected vascular prostheses in the groin? (2002) Srp Arh Celok Lek, 130 (1-2), pp. 27-32Papon, X., Villapadierna, F., Fournier, H.D., Brillu, C., Vialle, R., Mercier, P., High and low lateral approaches to the popliteal artery (1999) Surg Radiol Anat, 21, pp. 365-370Hoballah, J.J., Chalmers, R.T., Sharp, W.J., Kresowik, T.F., Martinasevic, M.M., Corson, J.D., Lateral approach to the popliteal and crural vessels for limb salvage (1996) Cardiovasc Surg, 4, pp. 165-168Padberg Jr., F.T., Lateral approach to the popliteal artery (1998) Ann Vasc Surg, 2, pp. 397-401Veith, F.J., Ascer, E., Gupte, S.K., Wengerter, K.R., Lateral approach to the popliteal artery (1987) J Vasc Surg, 6, pp. 119-123Nambisan, R.N., Karakousis, C.P., Vascular reconstruction for limb salvage in soft tissue sarcomas (1987) Surgery, 101, pp. 668-677Chammas, R., Aspectos fisiopatológicos da disseminação de sarcoma (1999) Sarcoma de Partes Moles, pp. 31-40. , Lopes A, editor. Rio de Janeiro: MedsiHohenberger, P., Allenberg, J.R., Schlag, P.M., Reichardt, P., Results of surgery and multimodal therapy for patients with soft tissue sarcoma invading to vascular structures (1999) Cancer, 85, pp. 396-408