Immunocytochemical Localization Of Cytokines And Inducible Nitric Oxide Synthase (inos) In Oral Mucosa And Lymph Nodes Of Patients With Paracoccidioidomycosis

dc.creatorNeworal E.P.M.
dc.creatorAltemani A.
dc.creatorMamoni R.L.
dc.creatorNoronha I.L.
dc.creatorBlotta M.H.S.L.
dc.date2003
dc.date2015-06-30T17:30:04Z
dc.date2015-11-26T14:08:24Z
dc.date2015-06-30T17:30:04Z
dc.date2015-11-26T14:08:24Z
dc.date.accessioned2018-03-28T21:08:58Z
dc.date.available2018-03-28T21:08:58Z
dc.identifier
dc.identifierCytokine. , v. 21, n. 5, p. 234 - 241, 2003.
dc.identifier10434666
dc.identifier10.1016/S1043-4666(03)00051-6
dc.identifierhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0038121653&partnerID=40&md5=3d4cf10fa30eba7681a703c25e7ab85a
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/102323
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/102323
dc.identifier2-s2.0-0038121653
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1240993
dc.descriptionParacoccidioidomycosis (PCM) is a deep mycosis caused by Paracoccidioides brasiliensis, with high incidence in Brazil. In order to examine the immune response in lesional tissue from patients with PCM, we analyzed cytokines as well as the phenotype of the cell infiltrate. Paraffin-embedded tissue from the oral mucosa of eight patients with the localized adult form (AF) of PCM and from the lymph nodes of 10 patients with the juvenile form (JF) of PCM was analyzed by immunohistochemistry to detect tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), transforming growth factor-β (TGF-β) and interleukin-10 (IL-10). Most of the inflammatory cells in the lymph nodes were CD68+ (macrophages, epithelioid and giant cells), while a mixed infiltrate with macrophages, plasma cells and neutrophils was detected in the oral mucosa. TNF-α as well as iNOS expression was similar in lymph nodes and oral mucosa, whereas TGF-β and IL-10 were observed in a larger number of macrophages, epithelioid and giant cells in the lymph nodes, where numerous yeast cells were visualized. The higher expression of anti-inflammatory cytokines (IL-10 and TGF-β) in lesions of patients with the JF of PCM (lymph nodes) may represent a mechanism by which the fungus evades the host immune response, contributing to a more severe and disseminated form of the disease. © 2003 Elsevier Science Ltd. All rights reserved.
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dc.languageen
dc.publisher
dc.relationCytokine
dc.rightsfechado
dc.sourceScopus
dc.titleImmunocytochemical Localization Of Cytokines And Inducible Nitric Oxide Synthase (inos) In Oral Mucosa And Lymph Nodes Of Patients With Paracoccidioidomycosis
dc.typeArtículos de revistas


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