Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening

dc.creatorDunder, Ricardo Jose
dc.creatorLuiz-Ferreira, Anderson
dc.creatorAlmeida, Ana Cristina Alves de
dc.creatorde-Faria, Felipe Meira
dc.creatorTakayama, Christiane
dc.creatorSocca, Eduardo Augusto Rabelo
dc.creatorSalvador, Marcos Jose
dc.creatorMello, Glaucia Coelho
dc.creatorSantos, Catarina dos
dc.creatorOliva-Neto, Pedro de
dc.creatorSouza-Brito, Alba Regina Monteiro
dc.date2013-05-01
dc.date2014-07-16T20:38:08Z
dc.date2015-11-26T11:56:48Z
dc.date2014-07-16T20:38:08Z
dc.date2015-11-26T11:56:48Z
dc.date.accessioned2018-03-28T20:59:43Z
dc.date.available2018-03-28T20:59:43Z
dc.identifierMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 108, n. 3, p. 263-271, 2013.
dc.identifier0074-0276
dc.identifierS0074-02762013000300263
dc.identifier10.1590/S0074-02762013000300002
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762013000300002
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000300263
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/21649
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/21649
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1238598
dc.descriptionThe present study evaluated the anti-inflammatory and analgesic properties of Agave sisalana Perrine in classic models of inflammation and pain. The hexanic fraction of A. sisalana (HFAS) was obtained by acid hydrolysis followed by hexanic reflux. Anti-inflammatory properties were examined in three acute mouse models (xylene ear oedema, hind paw oedema and pleurisy) and a chronic mouse model (granuloma cotton pellet). The antinociceptive potential was evaluated in chemical (acetic-acid) and thermal (tail-flick and hot-plate test) models of pain. When given orally, HFAS (5, 10, 25 and 50 mg/kg) reduced ear oedema (p < 0.0001; 52%, 71%, 62% and 42%, respectively). HFAS also reduced hind paw oedema at doses of 10 mg/kg and 25 mg/kg (p < 0.05; 42% and 58%, respectively) and pleurisy at doses of 10 mg/kg and 25 mg/kg (41% and 50%, respectively). In a chronic model, HFAS reduced inflammation by 46% and 58% at doses of 10 mg/kg and 25 mg/kg, respectively. Moreover, this fraction showed analgesic properties against the abdominal writhing in an acetic acid model (at doses of 5-25 mg/kg) with inhibitory rates of 24%, 54% and 48%. The HFAS also showed an increased latency time in the hot-plate (23% and 28%) and tail-flick tests (61% and 66%) for the 25 mg/kg and 50 mg/kg doses, respectively. These results suggest that HFAS has anti-inflammatory and analgesic properties.
dc.description263
dc.description271
dc.languageen
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relationMemórias do Instituto Oswaldo Cruz
dc.rightsaberto
dc.sourceSciELO
dc.subjectAgave sisalana Perrine ex Engelm
dc.subjecthecogenin
dc.subjecttigogenin
dc.subjectanti-inflammatory activity
dc.subjectanalgesic activity
dc.titleApplications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening
dc.typeArtículos de revistas


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