JAK2 V617F prevalence in Brazilian patients with polycythemia vera, idiopathic myelofibrosis and essential thrombocythemia

dc.creatorMonte-Mór, Bárbara da Costa Reis
dc.creatorCunha, Anderson Ferreira da
dc.creatorPagnano, Kátia Bórgia Barbosa
dc.creatorSaad, Sara Terezinha
dc.creatorLorand-Metze, Irene
dc.creatorCosta, Fernando Ferreira
dc.date2007-03-01
dc.date2014-07-18T17:44:03Z
dc.date2015-11-26T11:40:14Z
dc.date2014-07-18T17:44:03Z
dc.date2015-11-26T11:40:14Z
dc.date.accessioned2018-03-28T20:43:37Z
dc.date.available2018-03-28T20:43:37Z
dc.identifierGenetics and Molecular Biology. Sociedade Brasileira de Genética, v. 30, n. 2, p. 336-338, 2007.
dc.identifier1415-4757
dc.identifierS1415-47572007000300006
dc.identifier10.1590/S1415-47572007000300006
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572007000300006
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000300006
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/34345
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/34345
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1234417
dc.descriptionPolycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF) are myeloproliferative disorders (MPD) that arise from the clonal proliferation of a pluripotent hematopoietic progenitor, leading to the overproduction of one or more myeloid lineages. Recently, a specific mutation in the JAK2 gene, which encodes a tyrosine kinase, has been shown to be associated with the myeloproliferative phenotype observed in PV, ET and IMF. In this study of Brazilian patients, the JAK2 V617F mutation [c.1887G > T) was detected in four out of 49 patients with PV (96%), 14 out of 25 patients with IMF (56%), and in eight out of 29 patients with ET, which is in accordance with previous screenings of this mutation in other populations.
dc.description336
dc.description338
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherSociedade Brasileira de Genética
dc.relationGenetics and Molecular Biology
dc.rightsaberto
dc.sourceSciELO
dc.subjectJAK2 V617F
dc.subjectmyeloproliferative disorders
dc.subjectpolycythemia vera
dc.subjectidiopathic myelofibrosis
dc.subjectessential thrombocythemia
dc.titleJAK2 V617F prevalence in Brazilian patients with polycythemia vera, idiopathic myelofibrosis and essential thrombocythemia
dc.typeArtículos de revistas


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