The pharmacological effect of Bothrops neuwiedii pauloensis (jararaca-pintada) snake venom on avian neuromuscular transmission

dc.creatorBorja-Oliveira, C.R.
dc.creatorDurigon, A.M.
dc.creatorVallin, A.C.C.
dc.creatorToyama, M.H.
dc.creatorSouccar, C.
dc.creatorMarangoni, S.
dc.creatorRodrigues-Simioni, L.
dc.date2003-05-01
dc.date2014-07-17T15:05:03Z
dc.date2015-11-26T11:25:40Z
dc.date2014-07-17T15:05:03Z
dc.date2015-11-26T11:25:40Z
dc.date.accessioned2018-03-28T20:39:37Z
dc.date.available2018-03-28T20:39:37Z
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 5, p. 617-624, 2003.
dc.identifier0100-879X
dc.identifierS0100-879X2003000500009
dc.identifier10.1590/S0100-879X2003000500009
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2003000500009
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500009
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/24208
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/24208
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1233399
dc.descriptionThe neuromuscular effects of Bothrops neuwiedii pauloensis (jararaca-pintada) venom were studied on isolated chick biventer cervicis nerve-muscle preparations. Venom concentrations of 5-50 µg/ml produced an initial inhibition and a secondary increase of indirectly evoked twitches followed by a progressive concentration-dependent and irreversible neuromuscular blockade. At venom concentrations of 1-20 µg/ml, the responses to 13.4 mM KCl were inhibited whereas those to 110 µM acetylcholine alone and cumulative concentrations of 1 µM to 10 mM were unaffected. At venom concentrations higher than 50 µg/ml, there was pronounced muscle contracture with inhibition of the responses to acetylcholine, KCl and direct stimulation. At 20-24ºC, the venom (50 µg/ml) produced only partial neuromuscular blockade (30.7 ± 8.0%, N = 3) after 120 min and the initial inhibition and the secondary increase of the twitch responses caused by the venom were prolonged and pronounced and the response to KCl was unchanged. These results indicate that B.n. pauloensis venom is neurotoxic, acting primarily at presynaptic sites, and that enzyme activity may be involved in this pharmacological action.
dc.description617
dc.description624
dc.languageen
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceSciELO
dc.subjectChick biventer cervicis
dc.subjectMyotoxicity
dc.subjectNeurotoxicity
dc.subjectPhospholipase A2
dc.subjectPresynaptic action
dc.titleThe pharmacological effect of Bothrops neuwiedii pauloensis (jararaca-pintada) snake venom on avian neuromuscular transmission
dc.typeArtículos de revistas


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