Effects of caffeine on learning and memory in rats tested in the Morris water maze

dc.creatorAngelucci, M.E.M.
dc.creatorCesário, C.
dc.creatorHiroi, R.H.
dc.creatorRosalen, P.L.
dc.creatorCunha, C. Da
dc.date2002-10-01
dc.date2014-07-17T15:05:02Z
dc.date2015-11-26T11:25:28Z
dc.date2014-07-17T15:05:02Z
dc.date2015-11-26T11:25:28Z
dc.date.accessioned2018-03-28T20:39:26Z
dc.date.available2018-03-28T20:39:26Z
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 10, p. 1201-1208, 2002.
dc.identifier0100-879X
dc.identifierS0100-879X2002001000013
dc.identifier10.1590/S0100-879X2002001000013
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2002001000013
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000013
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/24199
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/24199
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1233350
dc.descriptionWe studied some of the characteristics of the improving effect of the non-specific adenosine receptor antagonist, caffeine, using an animal model of learning and memory. Groups of 12 adult male Wistar rats receiving caffeine (0.3-30 mg/kg, ip, in 0.1 ml/100 g body weight) administered 30 min before training, immediately after training, or 30 min before the test session were tested in the spatial version of the Morris water maze task. Post-training administration of caffeine improved memory retention at the doses of 0.3-10 mg/kg (the rats swam up to 600 cm less to find the platform in the test session, P<=0.05) but not at the dose of 30 mg/kg. Pre-test caffeine administration also caused a small increase in memory retrieval (the escape path of the rats was up to 500 cm shorter, P<=0.05). In contrast, pre-training caffeine administration did not alter the performance of the animals either in the training or in the test session. These data provide evidence that caffeine improves memory retention but not memory acquisition, explaining some discrepancies among reports in the literature.
dc.description1201
dc.description1208
dc.languageen
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceSciELO
dc.subjectMemory
dc.subjectLearning
dc.subjectCaffeine
dc.subjectMethylxanthines
dc.subjectAdenosine receptor antagonist
dc.subjectMorris water maze
dc.titleEffects of caffeine on learning and memory in rats tested in the Morris water maze
dc.typeArtículos de revistas


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