Reactivity of anti-thyroid antibodies to thyroglobulin tryptic fragments: comparison of autoimmune and non-autoimmune thyroid diseases

dc.creatorBoechat, L.H.B.
dc.creatorZollner, R.L.
dc.date1999-04-01
dc.date2014-07-17T15:04:58Z
dc.date2015-11-26T11:25:21Z
dc.date2014-07-17T15:04:58Z
dc.date2015-11-26T11:25:21Z
dc.date.accessioned2018-03-28T20:39:19Z
dc.date.available2018-03-28T20:39:19Z
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 4, p. 449-455, 1999.
dc.identifier0100-879X
dc.identifierS0100-879X1999000400012
dc.identifier10.1590/S0100-879X1999000400012
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1999000400012
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/24159
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/24159
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1233322
dc.descriptionStudies concerning the antigenicity of thyroglobulin fragments allow the characterization of the epitopes but do not consider the role of heavier antigenic fragments that could result in vivo from the action of endoproteases. Here we assess the relative importance of the fragments obtained from thyroglobulin by limited proteolysis with trypsin and compare by immunoblotting their reactivity to serum from patients with autoimmune (Graves' disease and Hashimoto's thyroiditis) and non-autoimmune (subacute thyroiditis) disease. The results showed no difference in frequency of recognition of any peptide by sera from patients with autoimmune thyroiditis. In contrast, sera from patients with subacute thyroiditis reacted more frequently with a peptide of 80 kDa. These results suggest the presence of antibody subpopulations directed at fragments produced in vivo by enzymatic cleavage of thyroglobulin. This fragment and antibodies to it may represent markers for subacute thyroiditis.
dc.description449
dc.description455
dc.languageen
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceSciELO
dc.subjectautoantibodies
dc.subjectautoimmunity
dc.subjectthyroglobulin
dc.subjecttrypsin
dc.subjectthyroiditis
dc.subjectproteases
dc.titleReactivity of anti-thyroid antibodies to thyroglobulin tryptic fragments: comparison of autoimmune and non-autoimmune thyroid diseases
dc.typeArtículos de revistas


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