Brasil | Artículos de revistas

Inhibitory effect of high [Mg2+] on the vasopressin-stimulated hydroosmotic permeability of the isolated perfused cortical collecting duct

dc.creatorFalkenstein, D.
dc.creatorRibeiro, C.A.L.
dc.creatorFigueiredo, J.F.
dc.date1999-08-01
dc.date2014-07-17T15:04:59Z
dc.date2015-11-26T11:25:21Z
dc.date2014-07-17T15:04:59Z
dc.date2015-11-26T11:25:21Z
dc.date.accessioned2018-03-28T20:39:19Z
dc.date.available2018-03-28T20:39:19Z
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 8, p. 1045-1049, 1999.
dc.identifier0100-879X
dc.identifierS0100-879X1999000800016
dc.identifier10.1590/S0100-879X1999000800016
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1999000800016
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800016
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/24162
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/24162
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1233321
dc.descriptionHigh magnesium concentration inhibits the effect of arginine vasopressin (AVP) on smooth muscle contraction and platelet aggregation and also influences hepatocyte AVP receptor binding. The aim of this study was to determine the role of magnesium concentration [Mg2+] in AVP-stimulated water transport in the kidney collecting duct. The effect of low and high peritubular [Mg2+] on the AVP-stimulated osmotic water permeability coefficient (Pf) was evaluated in the isolated perfused rabbit cortical collecting duct (CCD). Control tubules bathed and perfused with standard Ringer bicarbonate solution containing 1 mM Mg2+ presented a Pf of 223.9 ± 27.2 µm/s. When Mg2+ was not added to the bathing solution, an increase in the AVP-stimulated Pf to 363.1 ± 57.2 µm/s (P<0.05) was observed. An elevation of Mg2+ to 5 mM resulted in a decrease in Pf to 202.9 ± 12.6 µm/s (P<0.05). This decrease in the AVP-stimulated Pf at 5 mM Mg2+ persisted when the CCDs were returned to 1 mM Mg2+, Pf = 130.2 ± 20.3 µm/s, and was not normalized by the addition of 8-[4-chlorophenylthio]-adenosine 3',5'-cyclic monophosphate, a cAMP analogue, to the preparation. These data indicate that magnesium may play a modulatory role in the action of AVP on CCD osmotic water permeability, as observed in other tissues.
dc.description1045
dc.description1049
dc.languageen
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceSciELO
dc.subjectcortical collecting ducts
dc.subjectmagnesium
dc.subjectarginine vasopressin
dc.subjectosmotic water permeability
dc.titleInhibitory effect of high [Mg2+] on the vasopressin-stimulated hydroosmotic permeability of the isolated perfused cortical collecting duct
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución