Role of the hippocampus in contextual memory after classical aversive conditioning in pigeons (C. livia)

dc.creatorReis, F.
dc.creatorSchenka, A.A.
dc.creatorMelo, L.L.
dc.creatorFerrari, E.A.M.
dc.date1999-09-01
dc.date2014-07-17T15:04:59Z
dc.date2015-11-26T11:25:15Z
dc.date2014-07-17T15:04:59Z
dc.date2015-11-26T11:25:15Z
dc.date.accessioned2018-03-28T20:39:15Z
dc.date.available2018-03-28T20:39:15Z
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 9, p. 1127-1131, 1999.
dc.identifier0100-879X
dc.identifierS0100-879X1999000900012
dc.identifier10.1590/S0100-879X1999000900012
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1999000900012
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/24163
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/24163
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1233302
dc.descriptionWe investigated the effects of hippocampal lesions with ibotenic acid (IBO) on the memory of the sound-context-shock association during reexposure to the conditioning context. Twenty-nine adult pigeons were assigned to a non-lesioned control group (CG, N = 7), a sham-lesioned group (SG, N = 7), a hippocampus-lesioned experimental group (EG, N = 7), and to an unpaired nonlesioned group (tone-alone exposure) (NG, N = 8). All pigeons were submitted to a 20-min session in the conditioning chamber with three associations of sound (1000 Hz, 85 dB, 1 s) and shock (10 mA, 1 s). Experimental and sham lesions were performed 24 h later (EG and SG) when EG birds received three bilateral injections (anteroposterior (A), 4.5, 5.25 and 7.0) of IBO (1 µl and 1 µg/µl) and SG received one bilateral injection (A, 5.25) of PBS. The animals were reexposed to the training context 5 days after the lesion. Behavior was videotaped for 20 min and analyzed at 30-s intervals. A significantly higher percent rating of immobility was observed for CG (median, 95.1; range, 79.2 to 100.0) and SG (median, 90.0; range, 69.6 to 95.0) compared to EG (median, 11.62; range, 3.83 to 50.1) and NG (median, 7.33; range, 6.2 to 28.1) (P<0.001) in the training context. These results suggest impairment of contextual fear in birds who received lesions one day after conditioning and a role for the hippocampus in the modulation of emotional aversive memories in pigeons.
dc.description1127
dc.description1131
dc.languageen
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsaberto
dc.sourceSciELO
dc.subjectclassical aversive conditioning
dc.subjecthippocampus
dc.subjectfreezing
dc.subjectcontextual memory
dc.subjectpigeons
dc.titleRole of the hippocampus in contextual memory after classical aversive conditioning in pigeons (C. livia)
dc.typeArtículos de revistas


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