| dc.creator | Menegon, L.F. | |
| dc.creator | Figueiredo, J.F. | |
| dc.creator | Gontijo, J.A.R. | |
| dc.date | 1998-10-01 | |
| dc.date | 2014-07-17T15:04:58Z | |
| dc.date | 2015-11-26T11:25:14Z | |
| dc.date | 2014-07-17T15:04:58Z | |
| dc.date | 2015-11-26T11:25:14Z | |
| dc.date.accessioned | 2018-03-28T20:39:15Z | |
| dc.date.available | 2018-03-28T20:39:15Z | |
| dc.identifier | Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 10, p. 1269-1273, 1998. | |
| dc.identifier | 0100-879X | |
| dc.identifier | S0100-879X1998001000006 | |
| dc.identifier | 10.1590/S0100-879X1998001000006 | |
| dc.identifier | http://dx.doi.org/10.1590/S0100-879X1998001000006 | |
| dc.identifier | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001000006 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/24153 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/24153 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1233298 | |
| dc.description | Systemic metabolic acidosis is known to cause a decrease in salt and water reabsorption by the kidney. We have used renal lithium clearance to investigate the effect of chronic, NH4Cl-induced metabolic acidosis on the renal handling of Na+ in male Wistar-Hannover rats (200-250 g). Chronic acidosis (pH 7.16 ± 0.13) caused a sustained increase in renal fractional Na+ excretion (267.9 ± 36.4%), accompanied by an increase in fractional proximal (113.3 ± 3.6%) and post-proximal (179.7 ± 20.2%) Na+ and urinary K+ (163.4 ± 5.6%) excretion when compared to control and pair-fed rats. These differences occurred in spite of an unchanged creatinine clearance and Na+ filtered load. A lower final body weight was observed in the acidotic (232 ± 4.6 g) and pair-fed (225 ± 3.6 g) rats compared to the controls (258 ± 3.7 g). In contrast, there was a significant increase in the kidney weights of acidotic rats (1.73 ± 0.05 g) compared to the other experimental groups (control, 1.46 ± 0.05 g; pair-fed, 1.4 ± 0.05 g). We suggest that altered renal Na+ and K+ handling in acidotic rats may result from a reciprocal relationship between the level of metabolism in renal tubules and ion transport. | |
| dc.description | 1269 | |
| dc.description | 1273 | |
| dc.language | en | |
| dc.publisher | Associação Brasileira de Divulgação Científica | |
| dc.relation | Brazilian Journal of Medical and Biological Research | |
| dc.rights | aberto | |
| dc.source | SciELO | |
| dc.subject | renal function | |
| dc.subject | renal sodium excretion | |
| dc.subject | lithium clearance | |
| dc.subject | metabolic acidosis | |
| dc.title | Effect of metabolic acidosis on renal tubular sodium handling in rats as determined by lithium clearance | |
| dc.type | Artículos de revistas | |
