Antifungal activity of the ethanolic extracts of Punica granatum L. and evaluation of the morphological and structural modifications of its compounds upon the cells of Candida spp.

dc.creatorAnibal, Paula Cristina
dc.creatorPeixoto, Iza Teixeira Alves
dc.creatorFoglio, Mary Ann
dc.creatorHöfling, José Francisco
dc.date2013-09-01
dc.date2014-07-17T17:59:47Z
dc.date2015-11-25T20:07:31Z
dc.date2014-07-17T17:59:47Z
dc.date2015-11-25T20:07:31Z
dc.date.accessioned2018-03-28T20:38:51Z
dc.date.available2018-03-28T20:38:51Z
dc.identifierBrazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 44, n. 3, p. 839-848, 2013.
dc.identifier1517-8382
dc.identifierS1517-83822013000300027
dc.identifier10.1590/S1517-83822013005000060
dc.identifierhttp://dx.doi.org/10.1590/S1517-83822013005000060
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000300027
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/27571
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/27571
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1233196
dc.descriptionEthanolic crude extracts prepared from the arils and seeds, pericarp, peels and from the whole fruit of Punica granatum, known as pomegranate, had their antifungal activity tested against Candida spp. The ethanolic crude extracts were analyzed by Mass Spectrometry and yielded many compounds such as punicalagin and galladydilacton. The extracts from the pericarp and peel showed activity against Candida spp., with MICs of 125 µg/mL. The effect of pericarp and peel extracts upon the morphological and structure of C. albicans and C. krusei were examined by scanning and transmission electron microscopy, with the visualization of an irregular membrane and hyphae, formation of vacuoles and thickening of the cell wall. The data obtained revealed potential antimicrobial activity against yeasts cells of the Candida genus, and the bioactive compounds could be responsible for changes in cell morphology and structure. The data obtained open new perspectives for future research in continuation to this study, where information such as determination of the site of action of the compounds could contribute to an alternative therapy against these organisms.
dc.description839
dc.description848
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherSociedade Brasileira de Microbiologia
dc.relationBrazilian Journal of Microbiology
dc.rightsaberto
dc.sourceSciELO
dc.subjectPunica granatum
dc.subjectpunicalagin
dc.subjectantifungal activity
dc.subjectCandida spp.
dc.subjectelectron microscopy
dc.titleAntifungal activity of the ethanolic extracts of Punica granatum L. and evaluation of the morphological and structural modifications of its compounds upon the cells of Candida spp.
dc.typeArtículos de revistas


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