| dc.creator | Brocchi Marcelo [br] | |
| dc.creator | Pivetta Luciane Benedita Duarte [br] | |
| dc.date | 2012-10-26 | |
| dc.date | 2015-02-09T18:29:53Z | |
| dc.date | 2015-02-09T18:29:53Z | |
| dc.date | 07/03/2012 | |
| dc.date.accessioned | 2018-03-28T20:29:23Z | |
| dc.date.available | 2018-03-28T20:29:23Z | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/84836 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1230694 | |
| dc.description | A presente invenção revela uma nova alternativa para a prevenção de salmonelose, a partir de mutantes capazes de promover imunização do hospedeiro. Em especial tais mutantes são nulos para os genes hupA e/ou hz£1,B de HU e foram testados quanto a atenuação da virulência e capacidade de desencadear resposta imune efetiva e protetora contra a salmonelose, em especial a salmonelose murina, gerando resultados promissores. Adicionalmente, a presente invenção é destinada a um processo de produção desta linhagem atenuada, capaz de promover imunização, a vetores vacinais e vacinas para o tratamento de salmonelose e a seu uso no combate a tal infecção e possivelmente outras doenças, quando se tratando de vetores multifatoriais. | |
| dc.description | The present invention discloses a new alternative for preventing salmonellosis, using mutants capable of promoting host immunisation. particular, these mutants are null for the AU hupA and/or hupB genes, and were tested for virulence attenuation and ability to trigger an effective immune response protecting against salmonellosis, in particular murine salmonellosis, with promising results. In addition, the present invention is aimed at a method for producing this attenuated strain capable of promoting immunisation, at vaccine vectors and vaccines for the treatment of salmonellosis, and at the use thereof for combatting this infection and possibly other diseases, in the case of multifactorial vectors. | |
| dc.description | WO2012142684 (A1) | |
| dc.description | A61K39/02 | |
| dc.description | A61K39/112 | |
| dc.description | C12N15/00 | |
| dc.description | C12N15/31 | |
| dc.description | C12N15/73 | |
| dc.description | | |
| dc.description | WO2012BR00059 | |
| dc.description | A61K39/02 | |
| dc.description | A61K39/112 | |
| dc.description | C12N15/00 | |
| dc.description | C12N15/31 | |
| dc.description | C12N15/73 | |
| dc.description | WO2012009774 (A2) | |
| dc.description | WO9802523 (A1) | |
| dc.description | WO2004056973 (A2) | |
| dc.rights | aberto | |
| dc.title | Method For Constructing An Attenuated Mutant Strain Of Pathogenic Bacteria, Vaccine, Vaccine Vector And Use Of Said Vaccine | |
| dc.type | Patentes | |
