| dc.creator | Dias Luiz Carlos [br] | |
| dc.creator | Vieira Adriano Siqueira [br] | |
| dc.creator | Barreiro Eliezer Jesus De Lacerda [br] | |
| dc.date | 2012-11-01 | |
| dc.date | 2015-02-09T18:29:53Z | |
| dc.date | 2015-02-09T18:29:53Z | |
| dc.date | 25/11/2011 | |
| dc.date.accessioned | 2018-03-28T20:29:22Z | |
| dc.date.available | 2018-03-28T20:29:22Z | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/84834 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1230692 | |
| dc.description | A presente invenção refere-se a um processo para a obtenção de uma estatina, bem como a determinados compostos utilizados como intermediários no referido processo. Preferivelmente, a presente invenção refere-se a um processo para a obtenção de atorvastatina cídeica, bem como aos compostos 242-(4-Éluorofeni1)-2-oxo-l-feniletill-4-metil-3-oxo-N-fcnilpentanamida, 1-1.(R)- 64(S)-2,2-dimetil-1,3-dioxolan-441)-3-hidroxi-5-oxo-hexil]-5-(4-tluor-feni1)-2-isopropil-N,4-difenil-111-pirrol-3-carboxamida, 1- ((3R,5R)-64(5)-2,2-dirriefil-1,3-dioxolau-,441)-3,5-d iidroxiexil.)-5-(4-fhtorofeni l)-2-isopropil-N,4-di feni1-1H-pirrol-3-carboxamida e 5-(4-fluorofenil)-2-isopropil-N,4-difen.11-1-((3R,7S)-3,5,7,8-tetraidroxioetil)-1H-pirrol-3-earboxamida, os quais são utilizados como intermediários no referido processo. Além disso, a presente invenção refere-se ao método para a obtenção de uma estatina, preferivelmente atorvastatina calcica. A presente invenção refem-se ainda às estatinas obtidas a partir do método para a obtenção de uma estatina, preferivelmente atorvastatina cálcica. | |
| dc.description | The present invention relates to a method for preparing a statin, and to certain compound used as intermediates in this process. Preferably, the present invention relates to a method for preparing atorvastatin calcium, and to the following compounds: 2-[2(4-fluorophenyl)-2-oxo-1-phenylethy1]-4-methyl-3-oxo-N-phenylpentanaraide, 1-[(R)-6-((S)-2,2-dinamhy1-1,3-dioxolan-4-y1)-3-hydroxy-5-0xo-hexyll-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrol-3-carboxamide, 1-(3R,5R)-6-((S)-2,2-dimethyI-1,3-dioxolan-4-y1)-3,5-dihydroxyexyl)-5-(4-fluorophenyl)-2-isopropyl-N,4-difenil-1H-pirrol-3-carboxamida and 5-(4-fluorofeniI)-2-isopropil-N,4-difenil1-((3R,7S)-3,5,7,8-tetradroxioctil)-1H-pyrrol-3-carboxamide, which are used as intermediates in the method. Moreover, The present invention relates to the method for preparing a statin, preferably atorvastatin calcium, The present invention further relates to the statins prepared by the method for preparing e statin, preferably atovastatin calcium | |
| dc.description | WO2012145808 (A1) | |
| dc.description | C07D405/06 | |
| dc.description | C07D207/34 | |
| dc.description | | |
| dc.description | WO2011BR00450 | |
| dc.description | C07D405/06 | |
| dc.description | C07D207/34 | |
| dc.description | US2009209612 (A1) | |
| dc.description | US2009013683 (A1) | |
| dc.description | US6476235 (B2) | |
| dc.description | US5510488 (A) | |
| dc.rights | aberto | |
| dc.title | Method For Preparing Atorvastatin Calcium Using New Intermediates And Resulting Atorvastatin | |
| dc.type | Patentes | |
