Use Of Phthalimide And/or Sulphonamide Derivatives In The Treatment Of Diseases Which Require Reducing The Tnf-alpha Levels And An Exogenous Source Of Nitric Oxide, Phthalimide Derivatives, Sulphonamide Derivatives, And A Method For Obtaining A Sulphonamide Derivative

dc.creatorDos Santos Jean Leandro [br]
dc.creatorChung Man Chin [br]
dc.creatorMoreira Lima Lidia [br]
dc.creatorFerreira Costa Fernando [br]
dc.creatorLanaro Carolina [br]
dc.date2010-12-23
dc.date2015-02-09T18:29:39Z
dc.date2015-02-09T18:29:39Z
dc.date12/12/2008
dc.date.accessioned2018-03-28T20:28:58Z
dc.date.available2018-03-28T20:28:58Z
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/84708
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1230577
dc.descriptionThe present invention refers to the use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, which have important activities in increasing the gammaglobin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-cc levels and an exogenous source of nitric oxide. More particularly, the present invention describes the use of such phthalimide and/or sulphonamide derivatives for the treatment of sickle-cell disease. The invention also has as a novel characteristic the disclosure of new functionalized phthalimide derivatives designed from the prototypes thalidomide and hydroxyurea, and designed rationally through the strategy of molecular hybridization for the treatment of said diseases. The invention still discloses a new method for obtaining a specific sulphonamide derivative which can be used in the preparation of a drug for the treatment of diseases which require reducing the levels of the TNF-cc factor and an exogenous source of nitric oxide.
dc.descriptionUS2010324107 (A1)
dc.descriptionA61K31/4035
dc.descriptionA61P7/06
dc.descriptionA61P29/00
dc.descriptionC07C311/48
dc.descriptionC07D209/48
dc.description
dc.descriptionUS20080747589
dc.descriptionA61K31/4035
dc.descriptionA61P7/06
dc.descriptionA61P29/00
dc.descriptionC07C311/48
dc.descriptionC07D209/48
dc.rightsaberto
dc.titleUse Of Phthalimide And/or Sulphonamide Derivatives In The Treatment Of Diseases Which Require Reducing The Tnf-alpha Levels And An Exogenous Source Of Nitric Oxide, Phthalimide Derivatives, Sulphonamide Derivatives, And A Method For Obtaining A Sulphonamide Derivative
dc.typePatentes


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