Background: Exposure to body fluids and sharps is frequent in health personnel and is a major source of cross-infection. A study by Julia Villarroel shows us a record of 415 cases of exposure to risky body fluids, related to lack of experience and daytime workload ( 1 ). General Objective: to determine the factors associated with the risk of exposure to bodily fluids and sharps in the internal students of nursing at the University of Cuenca during the 2016 period. Methodology: the study was cross-sectional descriptive, with a finite universe of 149, of which 8 are removed from the boarding students and 13 surveys were not filled properly, so we worked with 128 internal nursing students. For the collection of information, a data collection form, which was validated with the implementation of the pilot plan, is prepared. Data analysis was conducted in the SPSS version 15, Microsoft Excel and Word whose results are presented in tables of frequencies and percentages. Results: Of 100% of respondents stated that 78.1% had suffered accidents due to exposure to body fluids and sharps. Exposure was the majority in the hospital area with 50.8%, in addition indicate that the largest exposure occurs in the morning shift with 39.8%, with blood being the main fluid involved with 70.3%. 75% indicate that the hands are in greater exposure to body fluids and sharps, the main type of contact being the splash in 57.8%. In relation to the number of patients attended, 86.2% of Internal of the hospital area serve less than 10 users and 38% of the community area between 10 to 20 users at each shift. 65.1% worked forty hours a weekLicenciado en EnfermeríaCuenca