Investigation was made on the climate change signal for hydrometeorological and hydrological variables along the Paute River basin, in the southern Ecuador Andes. An adjusted quantile perturbation approach was used for climate downscaling, and the impact of climate change on runoff was studied for two nested catchments within the basin. The analysis was done making use of long daily series of seven representative rainfall and temperature sites along the study area and considering climate change signals of global and regional climate models for IPCC SRES scenarios A1B, A2 and B1. The determination of runoff was carried out using a lumped conceptual rainfall–runoff model. The study found that the range of changes in temperature is homogeneous for almost the entire region with an average annual increase of approximately +2.0 ◦C. However, the warmest periods of the year show lower changes than the colder periods. For rainfall, downscaled results project increases in the mean annual rainfall depth and the extreme daily rainfall intensities along the basin for all sites and all scenarios. Higher changes in extreme rainfall intensities are for the wetter region. These lead to changes in catchment runoff flows, with increasing high peak flows and decreasing low peak flows. The changes in high peak flows are related to the changes in rainfall extremes, whereas the decreases in the low peak flows are due to the increase in temperature and potential evapotranspiration together with the reduction in the number of wet days.Cuencavol. 18; no. 2