Efecto Hepatoprotector del Extracto de las Hojas de AlcachofaCynara scolymus) en Ratas (Ratus novergicus) con Hepatotoxicidad Inducida por Tetracloruro de Carbono

Abstract

In the laboratories and the Biotherium of the School of Biochemistry and Pharmacy - ESPOCH. An investigation was carried out with the objective of testing the hepatoprotective effect of artichoke in rats with hepatotoxicity induced with carbon tetrachloride. The artichoke leaves extract was used and quality control and phytochemical screening were performed. It was experimented on rats divided into 3 groups: GA, GB, GC who received the extract, at a concentration of 100%, 50% and 25% respectively for 9 days, on the eighth day carbon tetrachloride was administered. ASAT and ALAT tests were performed and the livers were extracted for histopathological analysis. The ANOVA test was used for data analysis. In the phytochemical screening, alkaloids, flavonoids, phenolic compounds and triterpenes were found. In the ASAT and ALAT test in the GA group were elevated by an average of 2.39% of the normal value; GB increased by 42.6% and GC by 62.42%. In histopathological examination GA had 30% of liver destruction, GB 80% and GC 90%. Statistical analysis showed that transaminases are in direct proportion to hepatic destruction. Artichoke is hepatoprotective since in the transaminase tests and in the histopathological examination a slight hepatic damage was evidenced with high doses of the extract. It is recommended to elaborate a pharmaceutical form based on artichoke to be used as a coadjuvant treatment in people with hepatic diseases.