Search
Now showing items 11-20 of 5751
MRP4/ABCC4 as a new therapeutic target: meta-analysis to determine cAMP binding sites as a tool for drug design
(Bentham Science Publishers, 2017-12)
MRP4 transports multiple endogenous and exogenous substances and is critical not only for detoxification but also in the homeostasis of several signaling molecules. Its dysregulation has been reported in numerous pathological ...
The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets
(FERRATA STORTI FOUNDATIONPAVIA, 2012)
Background The malignant B cells in chronic lymphocytic leukemia receive signals from the bone marrow and lymph node microenvironments which regulate their survival and proliferation. Characterization of these signals and ...
Brown spider (Loxosceles) venom toxins as potential biotools for the development of novel therapeutics
(2019-06-01)
Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological ...
Ion pumps as targets for therapeutic intervention: Old and new paradigms
(Pontificia Universidad Católica de Valparaíso, 1998)
Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz., 2022)
Therapeutic targeting of autophagy in myocardial infarction and heart failure
(Taylor & Francis, 2016)
Introduction: Myocardial infarction (MI) is the leading cause of death. When MI is not lethal, heart failure (HF) is a major consequence with high prevalence and poor prognosis. The targeting of autophagy represents a ...
Advancements in the co-formulation of biologic therapeutics
Biologic therapeutics are the medicines of the future and are destined to transform the approaches
by which the causes and symptoms of diseases are cured and alleviated. These approaches will
be accelerated through the ...
Inteins in pathogenic fungi: a phylogenetic tool and perspectives for therapeutic applications
(Instituto Oswaldo Cruz, Ministério da Saúde, 2009-05-01)
Inteins or internal proteins are coding sequences that are transcribed and translated with flanking sequences (exteins). After translation, the inteins are excised by an autocatalytic process and the host protein assumes ...
Inteins in pathogenic fungi: a phylogenetic tool and perspectives for therapeutic applications
(Instituto Oswaldo Cruz, Ministério da Saúde, 2009-05-01)
Inteins or internal proteins are coding sequences that are transcribed and translated with flanking sequences (exteins). After translation, the inteins are excised by an autocatalytic process and the host protein assumes ...