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Effect of simvastatin on passive strain-induced skeletal muscle injury in rats
(WILEY-BLACKWELLHOBOKEN, 2012)
Introduction: HMG-CoA reductase inhibitors are the most frequently prescribed drugs for treatment of lipid imbalance, but they have side effects, such as myopathy. Our aim was to assess the effect of simvastatin on the ...
Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats
(Wiley-Blackwell Publishing, Inc, 2013)
Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells
(Spandidos Publications, 2015)
Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The ...
Simvastatin exhibits antiproliferative effects on spheres derived from canine mammary carcinoma cells
(Spandidos Publications, 2015)
Mammary cancer is the most frequent type of tumor in the female canine. Treatments are mainly limited to surgery and chemotherapy; however, these tumors may develop clinical recurrence, metastasis and chemoresistance. The ...
Simvastatin attenuates lung functional and vascular effects of hyperoxia in preterm rabbits
(Nature Pub Group, 2020-06)
Background: Bronchopulmonary dysplasia (BPD) remains a frequent complication following preterm birth, affecting respiratory health throughout life. Transcriptome analysis in a preterm rabbit model for BPD revealed dysregulation ...
Mesenchymal stromal cells-based therapy in a murine model of elastase-induced emphysema: Simvastatin as a potential adjuvant in cellular homing
(2021-10-01)
Chronic Obstructive Pulmonary Disease - COPD is characterized by the destruction of alveolar walls associated to a chronic inflammatory response of the airways. There is no clinical therapy for COPD. In this context, ...
Simvastatin improves cardiac function through Notch 1 activation in BALB/c mice with Chronic Chagas Cardiomyopathy
(American Society for Microbiology (ASM), 2020)
Chagas disease, caused by the protozoan Trypanosome cruzi, endemic in Latin America but distributed worldwide because of migration. Without appropriate treatment, the disease progresses from an acute asymptomatic phase to ...
Simvastatin-induced cardiac autonomic control improvement in fructose-fed female rats
(Faculdade de Medicina / USP, 2011)
OBJECTIVE: Because autonomic dysfunction has been found to lead to cardiometabolic disorders and because studies have reported that simvastatin treatment has neuroprotective effects, the objective of the present study was ...