Buscar
Mostrando ítems 31-40 de 5192
Structure-driven pharmacology of transient receptor potential channel vanilloid 1
(2016)
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a polymodal receptor that mediates the flux of cations across the membrane in response to several stimuli, including heat, voltage, and ligands. The best ...
Structure-driven pharmacology of transient receptor potential channel vanilloid 1
(2016)
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a polymodal receptor that mediates the flux of cations across the membrane in response to several stimuli, including heat, voltage, and ligands. The best ...
Pharmacological approaches in either intermittent or permanent hypoxia: a tale of two exposures
(2015)
Hypoxia induces several responses at cardiovascular, pulmonary and reproductive levels, which may lead to chronic diseases. This is relevant in human populations exposed to high altitude (HA), in either chronic continuous ...
Cardiovascular and ventilatory interactions in the facultative air-breathing teleost Pangasianodon hypophthalmus
(2019-08-01)
All vertebrates possess baroreceptors monitoring arterial blood pressure and eliciting reflexive changes in vascular resistance and heart rate in response to blood pressure perturbations imposed by, e.g., exercise, hypoxia, ...
Whole-Genome Analyses of Enterococcus faecium Isolates with Diverse Daptomycin MICs
(American Society for Microbiology, 2014)
Daptomycin (DAP) is a lipopeptide antibiotic frequently used as a "last-resort" antibiotic against vancomycin-resistant Enterococcus faecium (VRE). However, an important limitation for DAP therapy against VRE is the emergence ...
Whole-Genome Analyses of Enterococcus faecium Isolates with Diverse Daptomycin MICs
(American Society for Microbiology, 2014)
Daptomycin (DAP) is a lipopeptide antibiotic frequently used as a "last-resort" antibiotic against vancomycin-resistant Enterococcus faecium (VRE). However, an important limitation for DAP therapy against VRE is the emergence ...
Activity of boldine on rat ileum
(1991)
Boldine shows a concentration-dependent relaxation effect on the rat ileum preparation with a pD2 of 3.77 ± 0.12. The alkaloid also produces a concentration-dependent parallel shift of the curve-response to acetylcholine, ...
Translation controlled mRNAs: New drug targets in infectious diseases?
(Bentham Science Publishers B.V., 2009)
Recent data from a series of laboratories has pinpointed the relevant role of translation control on the regulation of gene expression. In particular, an analysis of T cell activation has led to demonstrate that during ...
Cross-talk with β2-adrenoceptors enhances ligand affinity properties from endothelial alpha1D-adrenoceptors that mediates carotid relaxation
(2013-09-01)
Objectives Our main objectives were to investigate the affinity properties of endothelial and muscular α1D-adrenoceptors and to characterize the cross-talk between endothelial α1D- adrenoceptors and β2-adrenoceptors in rat ...