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Correlation between mutations in liaFSR of enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpoints
(American Society for Microbiology, 2012)
Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a ...
Correlation between mutations in liaFSR of enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpoints
(American Society for Microbiology, 2012)
Mutations in liaFSR, a three-component regulatory system controlling cell-envelope stress response, were recently linked with the emergence of daptomycin (DAP) resistance in enterococci. Our previous work showed that a ...
Targeting the unfolded protein response for disease intervention
(Taylor & Francis, 2015)
Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER)
generates a stress condition that engages the unfolded protein response (UPR). The UPR is an
adaptive reaction that aims to reestablish ...
Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress
(Pergamon-Elsevier, 2016)
Hypoxia is the failure of oxygenation at the tissue level,where the reduced oxygen delivered is not enough to satisfy
tissue demands. Metabolic depression is the physiological adaptation associated with reduced oxygen ...
α4β2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
(2006)
α4 and β2 nicotinic acetylcholine receptor (nAChR) subunits expressed heterologously assemble into receptors with high (HS) and low (LS) sensitivity to acetylcholine (ACh); their relative proportions depend on the α4 to ...
Calcium channel antagonists and adenosine analogues decrease tolerance to opiate pentazocine and U 50488H
(1993)
1. A single dose of pentazocine induces cross-tolerance the analgesic effects of the kappa agonist U 50488H. Tolerance is observed by means of the hot plate test or by the i.p. administration of acetic acid 6 or 24 hr after ...
Antioxidant and neuroprotector effect of Lepidium meyenii (maca) methanol leaf extract against 6-hydroxy dopamine (6-OHDA)-induced toxicity in PC12 cells
(Taylor and Francis, 2017)
Reactive oxygen species (ROS) are normally produced during cell metabolism, there is strong evidence to suggest that ROS produced in excess impair the cell and may be etiologically related to various neurodegenerative ...
Review of pharmacological options for the treatment of Chagas disease
(Wiley Blackwell Publishing, Inc, 2020-12-13)
Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both rural and urban areas. CD was first described over a century ago, but only two drugs are currently available for CD treatment: ...
A novel hybrid promoter responsive to pathophysiological and pharmacological regulation
(Springer, 2012-04)
The aim of this study was to construct a promoter containing DNA motifs for an endogenous transcription factor associated with inflammation along with motifs for pharmacological regulation factors. We demonstrate in ...