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Inovações na produção de antibióticos β-lactâmicos
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Engenharia Química - PPGEQ, 2009-04-02)
The industrial production of 6-APA includes: (1) cultivation of Penicillium chrysogenum; (2) extraction with organic solvents, (3) crystallization; (4) penicillin hydrolysis by immobilized penicillin acylase; (5) extraction ...
EFEITO DE SURFACTANTES NA ESTABILIDADE DE COMPOSTOS DE USO TERAPEUTICO
(1990-12-01)
A critical revision of literature as regards to the drug stability in the presence of surfactants were realized. The functional groups envolved in the drug decomposition were used to the development of the discussion. The ...
EFEITO DE SURFACTANTES NA ESTABILIDADE DE COMPOSTOS DE USO TERAPEUTICO
(1990-12-01)
A critical revision of literature as regards to the drug stability in the presence of surfactants were realized. The functional groups envolved in the drug decomposition were used to the development of the discussion. The ...
Influence of activation on the multipoint immobilization of penicillin G acylase on macroporous silica
(Brazilian Society of Chemical Engineering, 2014)
Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation
(2012)
The first step in the penicillin biosynthetic pathway is the non-ribosomal condensation of l-α-aminoadipic acid, l-cysteine and l-valine into the tripeptide δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine (ACV). This reaction is ...
Anodic Polarographic Behaviour of Hydrolyzed
(1982)
The electroactivity of a degradation product from penicillin V is described.This electroactive product is formed by acidic hydrolysis at pH 4.0 and heating at 90QC for 60 minutes. This derivative has not been identified, ...