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Participación del gen c-H-ras en la proliferación y muerte de las células Molt-4
(07/03/2012)
RESUMEN: Los oncogenes detectados más frecuentemente en las neoplasias malignas humanas pertenecen a la familia de los genes ras (N-ras, H-ras y K-ras). El gen c-H-ras se localiza en la banda 15.5 del brazo corto del ...
No mutations found in exons of TP53, H-RAS and K-RAS genes in liver of male Wistar rats submitted to a medium-term chemical carcinogenesis assay
(Sociedade Brasileira de Patologia ClínicaSociedade Brasileira de PatologiaSociedade Brasileira de Citopatologia, 2014)
Fibroblast growth factor 2 restrains ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence
(AMER ASSOC CANCER RESEARCH, 2008)
Fibroblast growth factor 2 (FGF2) is considered to be a bona fide oncogenic factor, although results from our group and others call this into question. Here, we report that exogenous recombinant FGF2 irreversibly inhibits ...
Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice
(Oxford University Press, 2013-10)
Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving ...
Estudo da expressãode proteínas envolvidas nas vias de sinalização pl3k/akt e ras/erk em células endoteliais resistentes ao anoikis
(Universidade Federal de São Paulo (UNIFESP), 2014-07-30)
The acquisition of cell death resistance induced by blocking adhesion to the substrate (anoikis resistance) is a hallmark of neoplastic transformation and a critica I step during the metastatic processo PI3K1AKT and Ras/ERK ...
Mutações do gene N-ras em pacientes com mieloma multiplo
([s.n.], 2002)
Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K-ras and p53 Two-Hit Carcinogenesis Model
(American Association for Cancer Research, 2009-05)
Head and neck squamous cell carcinomas (HNSCC), the majority of which occur in the oral cavity, remain a significant cause of morbidity and mortality worldwide. Amajor limitation in HNSCC research has been the paucity of ...
Espectro de mutações em genes associados ao adenocarcinoma de pâncreas em pacientes do sudeste brasileiro
(Universidade Federal de Minas GeraisUFMG, 2013-08-22)
Introduction: Adenocarcinoma is the most prevalent histological type among tumors of the pancreas ( 90 % ) and has high mortality. The importance of understanding the pancreatic carcinogenesis is to determine new therapeutic ...