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The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
(Instituto Oswaldo Cruz, Ministério da Saúde, 2014)
Purposely engineered drug-target mismatches for entropy-based drug optimization
(Elsevier Science London, 2012-01)
Proteins are dynamic objects, often undergoing significant structural change and reducing their conformational possibilities upon binding to a ligand. Thus, unless dynamic information is incorporated, structure-based drug ...
Classical and alternative components of the mitochondrial respiratory chain in pathogenic fungi as potential therapeutic targets
(SPRINGER/PLENUM PUBLISHERS, 2011)
The frequency of opportunistic fungal infection has increased drastically, mainly in patients who are immunocompromised due to organ transplant, leukemia or HIV infection. In spite of this, only a few classes of drugs with ...
Antitumor Effect of Everolimus in a Patient with Type 3 Gastric Neuroendocrine Tumor
(KargerBaselSuíça, 2013)
BlueStar STING platform for analysis of protein structure / function relationship: designing agrochemicals to fit new protein targets for bacterial, fungal and insect control.
(In: COURSE ADVANCED TOPICS IN COMPUTATIONAL BIOLOGY AGROCHEMICAL AND DRUG DESIGN, 2012, Campinas. Lecture: abstracts. São Paulo: São Paulo School of Advanced Science, 2012., 2013)
Publisher Correction: Pharmacological targeting of the unfolded protein response for disease intervention (Nature Chemical Biology, (2019), 15, 8, (764-775), 10.1038/s41589-019-0326-2)
(Nature Publishing Group, 2019)
© 2019, Springer Nature America, Inc.An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Pharmacological targeting of the unfolded protein response for disease intervention
(Nature Publishing Group, 2019)
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of many human diseases including obesity, liver ...
Unravelling respiratory syncytial virus outbreaks in Buenos Aires, Argentina: Molecular basis of the spatio-temporal transmission
(Academic Press Inc Elsevier Science, 2017-08)
Respiratory syncytial virus (RSV) is the main viral cause of hospitalization due to acute lower respiratory tract infections in infants worldwide. Several vaccines against RSV are under research and development, which are ...
Modelagem molecular de grupos funcionais dos domínios Ets envolvidos na ligação ao DNA humano
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2008)
Considerando que alguns fatores de transcrição da família ETS regulam, crescimento, apoptose, angiogênese e genes relacionados a metástase em células tumorais, nós propomos modelos tridimensionais de domínios ETS (ETV- 2, ...