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Leptin action in the thymus
(Karger Publishers, 2018)
TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient - Effects on leptin and insulin signaling pathways
(Elsevier B.V., 2007-05-01)
Acting in the hypothalamus, tumor necrosis factor-alpha (TNF-alpha) produces a potent anorexigenic effect. However, the molecular mechanisms involved in this phenomenon are poorly characterized. In this study, we investigate ...
Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects
(Georg Thieme Verlag Kg, 2015-11)
Insulin and leptin receptors are known to share signaling pathways, such as JAK2/STAT-3 (Janus kinase2/signal transduction and activator of transcription3), MAPK (Mitogen activated protein kinase), and PI3K (phosphoinositide ...
Mechanisms involved in p53 downregulation by leptin in trophoblastic cells
(W B Saunders Co Ltd, 2015-11)
Leptin, a 16-kDa polypeptide hormone, is produced by the adipocyte and can also be synthesized by placenta. We previously demonstrated that leptin promotes proliferation and survival in placenta, in part mediated by the ...
Effects of leptin on pedunculopontine nucleus (PPN) neurons
(Springer Wien, 2013-07)
Leptin, a hormone that regulates appetite and energy expenditure, is increased in obese individuals, although these individuals often exhibit leptin resistance. Obesity is characterized by sleep/wake disturbances, such as ...
Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob/ob) mice
(Wiley-Blackwell, 2014-05-01)
AimLeptin, an adipocyte-derived hormone, is suggested to participate in the central control of breathing. We hypothesized that leptin may facilitate ventilatory responses to chemoreflex activation by acting on respiratory ...
Co-Expression of Leptin and Oestrogen Receptors in the Preoptic-Hypothalamic Area
(WILEY-BLACKWELL, 2010)
The interaction between the reproductive axis and energy balance suggests that leptin acts as a possible mediator. This hormone acts in the regulation of metabolism, feeding behaviour and reproduction. Animals homozygous ...
Leptin and the Immune Response An Active Player or an Innocent Bystander?
(BLACKWELL PUBLISHING, 2009)
Leptin is involved in the control of energy storage by the body. Low serum leptin levels, as seen in starvation, are associated with impaired inflammatory T cell responses that can be reversed by exogenous leptin. Common ...
Serum leptin levels after bariatric surgery across a range of glucose tolerance from normal to diabetes
(F D-communications IncTorontoCanadá, 2001)
Leptin as a potential prognostic marker of the severity of COVID-19 infection in obese patients
(Elsevier, 2022)
We read with great interest the article “Obesity as a risk factor for unfavorable outcomes in critically ill patients affected by COVID-19”, and we believe this is an important contribution toward understanding the ...