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Human supraphysiological gestational weight gain and fetoplacental vascular dysfunction
(2015)
OBJECTIVE: Human foetal development and growth in an environment of maternal obesity associates with high risk of cardiovascular disease and adverse neonatal outcome. We studied whether supraphysiological gestational weight ...
Adenosine a2a receptor regulates expression of vascular endothelial growth factor in feto-placental endothelium from normal and late onset pre-eclamptic pregnancies.
(2017)
We aim to investigate whether A(2A)/nitric oxide-mediated regulation of vascular endothelial growth factor (VEGF) expression is impaired in feto-placental endothelial cells from late-onset pre-eclampsia. Cultures of human ...
High total cholesterol and triglycerides levels increase arginases metabolism, impairing nitric oxide signaling and worsening fetoplacental endothelial dysfunction in gestational diabetes mellitus pregnancies
(2021-12-01)
Maternal physiological dyslipidemia (MPD) supports fetal development in human pregnancy. However, some women develop maternal supraphysiological dyslipidemia (MSPD: increased total cholesterol (TC) and triglycerides (TG) ...
Recombinant disintegrin targets alpha(v) beta(3) integrin and leads to mediator production
(Landes Bioscience, 2014-01-01)
Integrin alpha v beta 3 is most likely the foremost modulator of angiogenesis among all known integrins. Recombinant disintegrin DisBa-01, originally obtained from snake venom glands, binds to alpha v beta 3, thereby ...
Regulatory effects of estetrol on the endothelial plasminogen pathway and endothelial cell migration
(Elsevier Ireland, 2017-05)
BACKGROUND: Estetrol (E4) is a natural estrogen produced solely during human pregnancy. E4 is suitable for clinical use since it acts as a selective estrogen receptor modulator. In clinical trials E4 has been seen to have ...
c-Src kinase contributes on endothelial cells mechanotransduction in a heat shock protein 70-dependent turnover manner
(2019-07-01)
Shear stress changes are associated with a repertory of signaling cascade modulating vascular phenotype. As shear stress-related tensional forces might be associated with pathophysiological susceptibility, a more comprehensive ...