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Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol
(2002-07-08)
Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. The complex CDK9-cyclin T1 controls the elongation phase of ...
Preparation and characterization of poly(ε-caprolactone) nanospheres containing the local anesthetic lidocaine
(2013-01-01)
The objective of this work was to develop a modified release system for the local anesthetic lidocaine (LDC), using poly(ε-caprolactone) (PCL) nanospheres (NSs), to improve the pharmacological properties of the drug when ...
Preparation and characterization of poly(ε-caprolactone) nanospheres containing the local anesthetic lidocaine
(2013-01-01)
The objective of this work was to develop a modified release system for the local anesthetic lidocaine (LDC), using poly(ε-caprolactone) (PCL) nanospheres (NSs), to improve the pharmacological properties of the drug when ...
Development and clinical application of phosphorus-containing drugs
Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical
practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, ...
Estratégias biotecnológicas para a liberação controlada de antígenos e adjuvantes em vacinas através de lipossomas
(2006-10-01)
Liposomes (LP) are colloidal systems with ability to compartmentalize therapeutic molecules in order to improve biological activity, decreases the potential toxicity, and to obtain prolonged effect. In this work it was ...
Estratégias biotecnológicas para a liberação controlada de antígenos e adjuvantes em vacinas através de lipossomas
(2006-10-01)
Liposomes (LP) are colloidal systems with ability to compartmentalize therapeutic molecules in order to improve biological activity, decreases the potential toxicity, and to obtain prolonged effect. In this work it was ...
The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials
(2007-03-01)
EPSP synthase (EPSPS) is an essential enzyme in the shikimate pathway, transferring the enolpyruvyl group of phosphoenolpyruvate to shikimate-3-phosphate to form 5-enolpyruvyl-3-shikimate phosphate and inorganic phosphate. ...
The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials
(2007-03-01)
EPSP synthase (EPSPS) is an essential enzyme in the shikimate pathway, transferring the enolpyruvyl group of phosphoenolpyruvate to shikimate-3-phosphate to form 5-enolpyruvyl-3-shikimate phosphate and inorganic phosphate. ...
Effect of micelles, microemulsions and other supramolecular aggregates on the hydrolysis of β-lactam antibiotics
(1999-12-01)
A critical revision of the literature was made regarding the stability of β-lactam antibiotics in the presence of surfactants. The factors involved in the drug decomposition were analyzed in the development of the discussion. ...