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Mostrando ítems 891-900 de 1461
Chirality inversion, supramolecular hydrogelation and lectin binding of two thiolactose amphiphiles constructed on a di-lauroyl-L-tartaric acid scaffold
(Royal Society of Chemistry, 2017-11)
Herein we report the synthesis, characterization and self-assembly properties of two new thiolactose based amphiphiles constructed on a di-lauroyl-L-tartaric acid scaffold that only differ in the length of the spacer by ...
Self-homodimerization of an actinoporin by disulfide bridging reveals implications for their structure and pore formation
(Nature Publishing Group, 2018-12)
The Trp111 to Cys mutant of sticholysin I, an actinoporin from Stichodactyla helianthus sea anemone, forms a homodimer via a disulfide bridge. The purified dimer is 193 times less hemolytic than the monomer. Ultracentrifugation, ...
Control of Peptide Amphiphile Supramolecular Nanostructures by Isosteric Replacements
(American Chemical Society, 2021-08)
Supramolecular nanostructures with tunable properties can have applications in medicine, pharmacy, and biotechnology. In this work, we show that the self-assembly behavior of peptide amphiphiles (PAs) can be effectively ...
Heparin modulation of human plasma kallikrein on different substrates and inhibitors
(Walter de Gruyter & Co, 2006-08-01)
The interplay of different proteases and glycosaminoglycans is able to modulate the activity of the enzymes and to affect their structures. Human plasma kallikrein ( huPK) is a proteolytic enzyme involved in intrinsic blood ...
Cathepsin X binds to cell surface heparan sulfate proteoglycans
(Elsevier B.V., 2005-04-15)
Glycosaminoglycans have been shown to be important regulators of activity of several papain-like cathepsins. Binding of glycosaminoglycans to cathepsins thus directly affects catalytic activity, stability or the rate of ...
Ru(II)/clotrimazole/diphenylphosphine/bipyridine complexes: Interaction with DNA, BSA and biological potential against tumor cell lines and Mycobacterium tuberculosis
(2016-09-01)
Three ruthenium complexes [RuCl(CTZ)(bipy)(P-P)]PF6 [P-P = 1,2-bis(diphenylphosphino)ethane (dppe-1), 1,4-bis(diphenylphosphino)butane (dppb-2) and 1,1′-bis(diphenylphosphino)ferrocene (dppf-3), bipy = 2,2′-bipiridine and ...
Biophysical characterization of the recombinant merozoite surface protein-3 of Plasmodium vivax
(ELSEVIER SCIENCE BV, 2008)
Plasmodium vivax Merozoite Surface Protein-3 alpha and 3 beta are members of a family of related merozoite surface proteins that contain a central alanine-rich domain with heptad repeats that is predicted to form alpha-helical ...
Desenvolvimento de biossensor amperométrico baseado em monoamina oxidase-b para detecção de neurotransmissores
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Ciência dos Materiais - PPGCM-SoCâmpus Sorocaba, 2015-02-27)
This work focuses on the production of nanostructured films of poly (ethyleneimine) PEI together with MAO-b free and encapsulated in liposomes constructed by the layer-bylayer technique (LbL), for application in biosensors. ...
Expressão heterológa, purificação e caracterização estrutural do peptídeo (171-194) da p24 do HIV-1
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEv, 2004-01-01)
Proteins from the inner core of HIV-1 are involved in crucial processes during the virus life cycle. p24 is the major capsid protein of HIV and is initially expressed as part of the gag polyprotein. The association of gag ...
Gamma Ray Irradiation of the Vasoactive Peptide Bradykinin Reveals a Residue- and Position-Dependent Structural Modification
(Springer, 2010-06-01)
In this work the effect of radical species generated by gamma ray irradiation of aqueous solution upon structure of vasoactive peptide bradykinin (BK, RPPGFSPFR) was investigated. Increasing doses of 1-15 kGy Co-60 gamma ...