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Mostrando ítems 181-190 de 308
Myocardial function after fetal cardiac bypass in an ovine model
(Mosby-elsevierNew YorkEUA, 2011)
Inibidores de fosfodiesterases e o controle de processos proteolíticos na atrofia muscular induzida pelo diabetes mellitus
(Universidade Estadual Paulista (Unesp), 2018-04-27)
Considerando os avanços no conhecimento acerca dos mecanismos que controlam o metabolismo de proteínas na musculatura esquelética que permitiram a busca por novas opções para o tratamento das atrofias musculares, o presente ...
Phosphodiesterase 4 inhibition restrains muscle proteolysis in diabetic rats by activating PKA and EPAC/Akt effectors and inhibiting FoxO factors
(2021-08-01)
Aim: There is growing evidence about the ability of cyclic adenosine monophosphate (cAMP) signaling and nonselective phosphodiesterase (PDE) inhibitors on mitigate muscle atrophy. PDE4 accounts for the major cAMP hydrolyzing ...
Pro-apoptotic effects of low doses of dimethoate in rat brain
(Academic Press Inc Elsevier Science, 2019-01-15)
Dimethoate (DMT), a widely used Organophosphorous insecticide, was administered for 5 weeks (sub-chronic) at low dose (15 mg/kg b.w.) to male Wistar rats with the aim to simulate potential exposure to pesticide residues ...
Effect of copper overload on the survival of HepG2 and A-549 human-derived cells
(Sage Publications, 2013-03)
We investigated the effect of copper (Cu) overload (20–160 mM/24 h) in two cell lines of human hepatic (HepG2) and pulmonary (A-549) origin by determining lipid and protein damage and the response of the antioxidant defence ...
Photochemotherapy using natural anthraquinones: rubiadin and Soranjidiol sensitize human cancer cell to die by apoptosis
(Elsevier Science, 2014-03)
Over the past decade the science has studied synthetic photosensitizers used in photodynamic therapy (PDT) or photochemotherapy as anticancer candidates. In this context, compounds extracted from vegetable species present ...
Single nucleotide polymorphisms in CAPN and leptin genes associated with meat color and tenderness in Nellore cattle
(2011)
We analyzed single nucleotide polymorphisms in calpain, leptin, leptin receptor, and growth hormone receptor genes and their association with color, drip and cooking losses of longissimus muscle at 7, 14 and 21 days ...
Regulation of PfEMP1-VAR2CSA translation by a Plasmodium translation-enhancing factor
Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate A (CSA) through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed ...