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Hepatitis C virus treatment failure: Clinical utility for testing resistance-associated substitutions
(Baishideng Publishing Group, 2021-09)
The hepatitis C virus has a high mutation capacity that leads to the emergence of resistance-associated substitutions (RAS). However, the consequence of resistance selection during new direct-acting antiviral drug (DAA) ...
Cytochrome P450 Herbicide Metabolism as the Main Mechanism of Cross-Resistance to ACCase- and ALS-Inhibitors in Lolium spp. Populations From Argentina: A Molecular Approach in Characterization and Detection
(Frontiers Media, 2020-11)
Knowledge about the mechanisms of herbicide resistance provide valuable insights into evolving weed populations in response to selection pressure and should be used as a basis for designing management strategies for ...
Prevalência de variantes associadas à resistência aos inibidores de protease em hemodialisados e transplantados renais com infecção pelo virus da hepatite C
(Universidade Federal de São Paulo (UNIFESP), 2016-08-30)
NS3 protease inhibitors (PIs) were the first direct antiviral agents (DAAs) for the treatment of hepatitis C virus. The combination of second-wave PIs with other DAAs permitted the use of interferon-free regimens for chronic ...
The Gly972Arg polymorphism in insulin receptor substrate-1 is associated with decreased birth weight in a population-based sample of Brazilian newborns
(Amer Diabetes AssocAlexandriaEUA, 2002)
Characterization of in vitro dengue virus resistance to carrageenan
(Wiley-liss, Div John Wiley & Sons Inc, 2016-07)
The λ-carrageenan (λ-car) is a potent and selective inhibitor of dengue virus (DENV) infection targeted to virus adsorption and internalization, due to the structural similarities with the mammalian cell receptor heparan ...
Role of genetic variation in insulin-like growth factor 1 receptor on insulin resistance and arterial hypertension
(Lippincott Williams, 2010-02)
OBJECTIVE: To perform a two-stage study to explore the role of gene variants in the risk of insulin resistance and arterial hypertension. METHODS AND RESULTS: The selection of variants was performed by a first stage of ...
A double EPSPS gene mutation endowing glyphosate resistance shows a remarkably high resistance cost
(Wiley Blackwell Publishing, Inc, 2017-12)
A novel glyphosate resistance double point mutation (T102I/P106S, TIPS) in the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene has been recently identified for the first time only in the weed species Eleusine ...
Genome wide association analysis for resistance to Caligus rogercresseyi in atlantic salmon (Salmo salar L.)
(2017)
The sea louse (Caligus rogercresseyi) is an external parasite and considered one of the most important health problems in the salmon farming industry. Resistance to conventional chemical treatments has been demonstrated. ...
A haplotype at intron 8 of PTPRT gene is associated with resistance to Brucella infection in Argentinian creole goats
(Elsevier Science, 2017-08)
Brucellosis is the leading zoonosis on a worldwide scale and constitutes a major public health threat in many regions of the world. Several molecular markers associated with natural resistance to intracellular bacterial ...