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Development of DNA vaccines against hemolytic-uremic syndrome in a murine model
(American Society for Microbiology, 2003-07)
Shiga toxin type 2 (Stx2) produced by Escherichia coli O:157H7 can cause hemolytic-uremic syndrome in children, a disease for which there is neither a vaccine nor an effective treatment. This toxin consists of an enzymatically ...
α-Synuclein and lipid metabolism: intersecting pathways
(Tech Science Press, 2019)
α-synuclein (α-syn) aggregation and fibrillation is a hallmark of a class of neurodegenerative disorders known as synucleinopathies. An intriguing and not completely clarified feature of α-syn is the many ways in which it ...
Junín virus induces autophagy in human A549 cells
(Public Library of Science, 2019-06-19)
Autophagy, a highly regulated degradative process that promotes cellular homeostasis, is increasingly recognised as a fundamental component of the cellular response against viral infection. In this study, we investigated ...
A non-coding RNA network involved in KSHV tumorigenesis
(Frontiers Media S.A., 2021-06-16)
Regulatory pathways involving non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNA), have gained great relevance due to their role in the control of gene expression modulation. Using RNA ...
Mycoviruses in biological control: From basic research to field implementation
(American Phytopathological Society, 2019-08)
Mycoviruses from plant pathogens can induce hypovirulence (reduced virulence) in their host fungi and have gained considerable attention as potential biocontrol tools. An increasing number of mycoviruses that induce fungal ...
Ghrelin Selectively Inhibits CaV3.3 Subtype of Low-Voltage-Gated Calcium Channels
(Humana Press, 2019-08-29)
The mechanisms by which ghrelin controls electrical activity in the hypothalamus are not fully understood. One unexploredtarget of ghrelin is CaV3, responsible for transient calcium currents (T-currents) that control ...
The activation of the G protein-coupled estrogen receptor (GPER) prevents and regresses cardiac hypertrophy
(Elsevier Inc, 2020-02-01)
Ventricular hypertrophy is a risk factors for arrhythmias, ischemia and sudden death. It involves cellular modifications leading to a pathological remodeling and is associated with heart failure. The activation of the G ...
Foot-and-Mouth Disease: Optimization, Reproducibility, and Scalability of High-Yield Production of Virus-Like Particles for a Next-Generation Vaccine
(Frontiers Media, 2020-09-23)
Inactivated Foot-and-Mouth Disease (FMD) vaccine has proven to be effective in the control of the disease. However, its production has some disadvantages, including the costly biosafety facilities required for the production ...
Characterization and functional analysis of the proteins prohibitin 1 and 2 in trypanosoma cruzi
(Public Library of Science, 2021-04-08)
Background Chagas disease is the third most important neglected tropical disease. There is no vaccine available, and only two drugs are generally prescribed for the treatment, both of which with a wide range of side effects. ...
Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells
(Endocrine Society, 2005-12)
Uterine decidualization is characterized by stromal cell proliferation and differentiation, which are controlled by ovarian hormones estradiol and progesterone. Here we report that the proliferative response of UIII rat ...